Ensembl ID ENSG00000145833 Gene ID 9879 Accession 18681
Gene Symbol DDX46 Alias Prp5;PRPF5 Full Name DEAD-box helicase 46
Position 5 : 134758771 - 134855133 Length 96363 bases Strand Plus strand
Status Confidence Main interacting RNAssnRNARBP type Canonical_RBPs
Summary This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

ENSG00000145833 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000145833 DDX46 colorectal cancer 25680556
ENSG00000145833 DDX46 cancer 27078856
ENSG00000145833 DDX46 tumors 27697093
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000145833 DDX46 SARC 0.046 high
ENSG00000145833 DDX46 THCA 0.02 high
ENSG00000145833 DDX46 LGG 0.011 high
ENSG00000145833 DDX46 LUSC 0.0084 low
ENSG00000145833 DDX46 HNSC 0.00069 low
ENSG00000145833 DDX46 KICH 0.0029 high
ENSG00000145833 DDX46 PCPG 0.031 high
ENSG00000145833 DDX46 THYM 0.023 low
ENSG00000145833 DDX46 COAD 0.00066 low
ENSG00000145833 DDX46 DLBC 0.046 low
ENSG00000145833 DDX46 PRAD 0.036 high
ENSG00000145833 DDX46 TGCT 0.041 high
ENSG00000145833 DDX46 BLCA 0.0042 high
ENSG00000145833 DDX46 LAML 0.0024 low
ENSG00000145833 DDX46 GBM 0.019 low
ENSG00000145833 DDX46 SKCM 0.046 low
ENSG00000145833 DDX46 LIHC 0.00096 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000145833 DDX46 LAML Del 6.887040 0.098062 0.799843 0.089005
ENSG00000145833 DDX46 LUAD Del 2.839459 0.075324 0.345987 0.408915
ENSG00000145833 DDX46 LGG Del 0.789564 0.039887 0.383767 0.087719
ENSG00000145833 DDX46 ACC Amp 0.765694 0.253036 1.228982 0.666667
ENSG00000145833 DDX46 COAD Del 0.834085 0.043930 0.389674 0.219512
ENSG00000145833 DDX46 SKCM Del 2.811986 0.097645 0.487813 0.318801
ENSG00000145833 DDX46 PCPG Del 0.631226 0.056137 0.663237 0.074074
ENSG00000145833 DDX46 STAD Del 2.003820 0.078560 0.384817 0.333333
ENSG00000145833 DDX46 KIRC Amp 45.433636 0.270302 0.535982 0.596591