Ensembl ID ENSG00000145050 Gene ID 7873 Accession 15461
Gene Symbol MANF Alias ARP;ARMET Full Name mesencephalic astrocyte derived neurotrophic factor
Position 3 : 51385291 - 51389397 Length 4107 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

ENSG00000145050 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000145050 1.12 6.41e-70 BRCA
ENSG00000145050 0.67 6.32e-13 COAD
ENSG00000145050 0.88 1.87e-13 KICH
ENSG00000145050 0.68 2.98e-14 LUSC
ENSG00000145050 0.99 2.92e-14 LIHC
ENSG00000145050 1.38 2.53e-23 UCEC
ENSG00000145050 1.37 3.72e-49 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000145050 cancers 10767373
ENSG00000145050 tumors 17507765
ENSG00000145050 tumors 19199705
ENSG00000145050 tumors 19399876
ENSG00000145050 tumors 19773801
ENSG00000145050 colorectal cancer 21984158
ENSG00000145050 tumors 22120531
ENSG00000145050 tumors 23173607
ENSG00000145050 pancreatic cancer 23227827
ENSG00000145050 cancer 25543119
ENSG00000145050 tumors 26106154
ENSG00000145050 tumors 26429332
ENSG00000145050 Tumors 28154531
ENSG00000145050 cancers 28407594
ENSG00000145050 tumors 28955781
ENSG00000145050 ovarian cancer 29456732
ENSG00000145050 tumors 29587239
ENSG00000145050 tumours 30543055
ENSG00000145050 Wilms' tumor 30641926
ENSG00000145050 cancer 31229549
ENSG00000145050 Liver Cancer 31469428
ENSG00000145050 tumors 31666439
ENSG00000145050 tumors 31754114
ENSG00000145050 prostate cancers 8971156
ENSG00000145050 pancreatic cancer 9174057
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000145050 SARC 0.0031 high
ENSG00000145050 CHOL 0.038 high
ENSG00000145050 UVM 0.0019 high
ENSG00000145050 PAAD 0.028 high
ENSG00000145050 UCEC 0.017 low
ENSG00000145050 ACC 0.0028 high
ENSG00000145050 KIRP 0.038 high
ENSG00000145050 KICH 0.028 high
ENSG00000145050 LUAD 0.011 low
ENSG00000145050 PCPG 0.028 low
ENSG00000145050 THYM 0.0021 low
ENSG00000145050 BRCA 0.0059 low
ENSG00000145050 COAD 0.01 low
ENSG00000145050 ESCA 0.024 high
ENSG00000145050 OV 0.00045 low
ENSG00000145050 DLBC 0.021 low
ENSG00000145050 TGCT 0.005 low
ENSG00000145050 LAML 0.0017 low
ENSG00000145050 GBM 0.013 high
ENSG00000145050 SKCM 0.00057 low
ENSG00000145050 LIHC 0.00024 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000145050 CHOL Del 0.615751 0.195478 0.624502 0.805556
ENSG00000145050 LUSC Del 5.305114 0.116045 0.415488 0.870259
ENSG00000145050 LUAD Del 1.132425 0.057280 0.323315 0.472868
ENSG00000145050 LGG Del 2.345546 0.055293 0.504931 0.095517
ENSG00000145050 CESC Del 0.740533 0.067528 0.536181 0.413559
ENSG00000145050 READ Del 0.783274 0.074801 0.419249 0.157576
ENSG00000145050 COAD Del 1.784636 0.054012 0.430084 0.159645
ENSG00000145050 UCS Del 1.579641 0.278396 0.523141 0.625000
ENSG00000145050 SARC Del 1.809143 0.152919 0.533745 0.249027
ENSG00000145050 ESCA Del 2.361556 0.142392 0.449926 0.668478
ENSG00000145050 HNSC Del 1.260722 0.060977 0.435962 0.720307
ENSG00000145050 BLCA Del 6.743296 0.150987 0.416388 0.296569
ENSG00000145050 BRCA Del 29.508504 0.175630 0.459785 0.323148
ENSG00000145050 STAD Del 5.062209 0.109001 0.340881 0.340136
ENSG00000145050 UCEC Del 2.524279 0.068293 0.493531 0.137291
ENSG00000145050 MESO Del 17.405056 0.552525 0.567689 0.517241
ENSG00000145050 KIRC Del 51.000448 0.180237 0.516342 0.880682
ENSG00000145050 OV Del 1.242621 0.187360 0.485130 0.338515