Ensembl ID ENSG00000144218 Gene ID 3899 Accession 6473
Gene Symbol AFF3 Alias KINS;LAF4;MLLT2-like Full Name ALF transcription elongation factor 3
Position 2 : 99545419 - 100142590 Length 597172 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000144218 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000144218 AFF3 1.44 1.52e-26 KIRC
ENSG00000144218 AFF3 -3.8 2.63e-16 BLCA
ENSG00000144218 AFF3 -2.9 1.76e-36 COAD
ENSG00000144218 AFF3 -3.7 4.58e-27 READ
ENSG00000144218 AFF3 -3.4 1.75e-49 LUSC
ENSG00000144218 AFF3 -2.3 1.33e-28 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000144218 AFF3 tumor 12947006
ENSG00000144218 AFF3 tumour 20444755
ENSG00000144218 AFF3 breast cancers 26214578
ENSG00000144218 AFF3 tumor 26483173
ENSG00000144218 AFF3 tumors 27245147
ENSG00000144218 AFF3 GBM 28035070
ENSG00000144218 AFF3 breast cancer 28401970
ENSG00000144218 AFF3 tumor 30031117
ENSG00000144218 AFF3 breast cancers 30326937
ENSG00000144218 AFF3 tumours 31000732
ENSG00000144218 AFF3 cancer 9299237
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000144218 AFF3 B-cell acute lymphoblastic leukemia gene_fusion 70.17% (127/181) 4 entries
ENSG00000144218 AFF3 esophageal adenocarcinoma missense_variant 32.65% (143/438) 1 entry
ENSG00000144218 AFF3 prostate adenocarcinoma sequence_alteration 14.92% (217/1454) 2 entries
ENSG00000144218 AFF3 prostate adenocarcinoma missense_variant 14.92% (217/1454) 3 entries
ENSG00000144218 AFF3 breast ductal adenocarcinoma sequence_alteration 45.21% (264/584) 2 entries
ENSG00000144218 AFF3 breast ductal adenocarcinoma missense_variant 45.21% (264/584) 1 entry
ENSG00000144218 AFF3 pancreatic ductal adenocarcinoma missense_variant 19.54% (246/1259) 1 entry
ENSG00000144218 AFF3 esophageal adenocarcinoma sequence_alteration 32.65% (143/438) 1 entry
ENSG00000144218 AFF3 colon adenocarcinoma sequence_alteration 3.586% (27/753) 4 entries
ENSG00000144218 AFF3 hepatocellular carcinoma missense_variant 2.331% (21/901) 1 entry
ENSG00000144218 AFF3 head and neck squamous cell carcinoma missense_variant 0.9539% (6/629) 1 entry
ENSG00000144218 AFF3 colorectal adenocarcinoma frameshift_variant 7.733% (88/1138) 2 entries
ENSG00000144218 AFF3 squamous cell lung carcinoma missense_variant 3.281% (25/762) 2 entries
ENSG00000144218 AFF3 diffuse large B-cell lymphoma sequence_alteration 0.6601% (2/303) 1 entry
ENSG00000144218 AFF3 colorectal adenocarcinoma stop_gained 7.733% (88/1138) 2 entries
ENSG00000144218 AFF3 basal cell carcinoma missense_variant 12.07% (7/58) 1 entry
ENSG00000144218 AFF3 embryonal rhabdomyosarcoma missense_variant 2.632% (2/76) 2 entries
ENSG00000144218 AFF3 small cell lung carcinoma missense_variant 2.194% (7/319) 3 entries
ENSG00000144218 AFF3 colorectal adenocarcinoma sequence_alteration 7.733% (88/1138) 2 entries
ENSG00000144218 AFF3 rectal adenocarcinoma missense_variant 1.357% (3/221) 1 entry
ENSG00000144218 AFF3 colon adenocarcinoma missense_variant 3.586% (27/753) 6 entries
ENSG00000144218 AFF3 gastric adenocarcinoma missense_variant 2.798% (19/679) 1 entry
ENSG00000144218 AFF3 female breast carcinoma sequence_alteration 2.996% (8/267) 1 entry
ENSG00000144218 AFF3 ependymoma sequence_alteration 4.348% (2/46) 1 entry
ENSG00000144218 AFF3 colon adenocarcinoma stop_gained 3.586% (27/753) 1 entry
ENSG00000144218 AFF3 HER2 Positive Breast Carcinoma missense_variant 32.58% (43/132) 1 entry
ENSG00000144218 AFF3 oral squamous cell carcinoma missense_variant 0.9756% (2/205) 2 entries
ENSG00000144218 AFF3 lung adenocarcinoma missense_variant 2.064% (24/1163) 4 entries
ENSG00000144218 AFF3 esophageal squamous cell carcinoma sequence_alteration 2.37% (16/675) 2 entries
ENSG00000144218 AFF3 lung adenocarcinoma stop_gained 2.064% (24/1163) 2 entries
ENSG00000144218 AFF3 prostate carcinoma sequence_alteration 8.451% (36/426) 2 entries
ENSG00000144218 AFF3 squamous cell lung carcinoma sequence_alteration 3.281% (25/762) 1 entry
ENSG00000144218 AFF3 skin melanoma sequence_alteration 3.826% (37/967) 1 entry
ENSG00000144218 AFF3 cecum adenocarcinoma missense_variant 3.053% (4/131) 2 entries
ENSG00000144218 AFF3 skin melanoma missense_variant 3.826% (37/967) 5 entries
ENSG00000144218 AFF3 ovarian serous adenocarcinoma missense_variant 0.4458% (3/673) 1 entry
ENSG00000144218 AFF3 acute myeloid leukemia sequence_alteration 1.433% (13/907) 1 entry
ENSG00000144218 AFF3 nasopharyngeal squamous cell carcinoma missense_variant 2.395% (4/167) 1 entry
ENSG00000144218 AFF3 lung adenocarcinoma sequence_alteration 2.064% (24/1163) 3 entries
ENSG00000144218 AFF3 esophageal squamous cell carcinoma stop_gained 2.37% (16/675) 1 entry
ENSG00000144218 AFF3 small cell lung carcinoma sequence_alteration 2.194% (7/319) 2 entries
ENSG00000144218 AFF3 brain glioblastoma sequence_alteration 0.6479% (6/926) 2 entries
ENSG00000144218 AFF3 Merkel cell skin cancer sequence_alteration 13.33% (4/30) 2 entries
ENSG00000144218 AFF3 melanoma missense_variant 6.931% (7/101) 2 entries
ENSG00000144218 AFF3 clear cell renal carcinoma sequence_alteration 1.161% (16/1378) 2 entries
ENSG00000144218 AFF3 colorectal adenocarcinoma missense_variant 7.733% (88/1138) 3 entries
ENSG00000144218 AFF3 head and neck squamous cell carcinoma sequence_alteration 0.9539% (6/629) 1 entry
ENSG00000144218 AFF3 Brain Stem Glioblastoma sequence_alteration 7.143% (4/56) 1 entry
ENSG00000144218 AFF3 esophageal squamous cell carcinoma missense_variant 2.37% (16/675) 5 entries
ENSG00000144218 AFF3 chronic lymphocytic leukemia sequence_alteration 3.941% (35/888) 1 entry
ENSG00000144218 AFF3 gastric intestinal type adenocarcinoma missense_variant 3.529% (3/85) 1 entry
ENSG00000144218 AFF3 anaplastic astrocytoma sequence_alteration 2.222% (1/45) 1 entry
ENSG00000144218 AFF3 hemangioblastoma sequence_alteration 3.125% (1/32) 1 entry
ENSG00000144218 AFF3 female breast carcinoma frameshift_variant 2.996% (8/267) 1 entry
ENSG00000144218 AFF3 brain glioma sequence_alteration 11.11% (1/9) 1 entry
ENSG00000144218 AFF3 bronchoalveolar adenocarcinoma sequence_alteration 9.091% (2/22) 1 entry
ENSG00000144218 AFF3 prostate carcinoma missense_variant 8.451% (36/426) 1 entry
ENSG00000144218 AFF3 diffuse large B-cell lymphoma missense_variant 0.6601% (2/303) 1 entry
ENSG00000144218 AFF3 Pancreatic Acinar Cell Carcinoma missense_variant 5.0% (1/20) 1 entry
ENSG00000144218 AFF3 colon adenocarcinoma conservative_inframe_deletion 3.586% (27/753) 1 entry
ENSG00000144218 AFF3 Merkel cell skin cancer missense_variant 13.33% (4/30) 1 entry
ENSG00000144218 AFF3 Invasive Breast Carcinoma missense_variant 2.222% (1/45) 1 entry
ENSG00000144218 AFF3 diffuse gastric adenocarcinoma stop_gained 2.532% (2/79) 1 entry
ENSG00000144218 AFF3 hepatocellular carcinoma conservative_inframe_deletion 2.331% (21/901) 1 entry
ENSG00000144218 AFF3 medullary thyroid gland carcinoma missense_variant 5.263% (1/19) 1 entry
ENSG00000144218 AFF3 head and neck squamous cell carcinoma stop_gained 0.9539% (6/629) 1 entry
ENSG00000144218 AFF3 head and neck squamous cell carcinoma conservative_inframe_deletion 0.9539% (6/629) 1 entry
ENSG00000144218 AFF3 gastric adenocarcinoma sequence_alteration 2.798% (19/679) 1 entry
ENSG00000144218 AFF3 bile duct adenocarcinoma sequence_alteration 0.5291% (1/189) 1 entry
ENSG00000144218 AFF3 alveolar rhabdomyosarcoma missense_variant 1.695% (1/59) 1 entry
ENSG00000144218 AFF3 diffuse gastric adenocarcinoma sequence_alteration 2.532% (2/79) 1 entry
ENSG00000144218 AFF3 T-cell acute lymphoblastic leukemia conservative_inframe_deletion 0.7895% (3/380) 1 entry
ENSG00000144218 AFF3 prostate carcinoma frameshift_variant 8.451% (36/426) 1 entry
ENSG00000144218 AFF3 glioma sequence_alteration 0.3454% (2/579) 1 entry
ENSG00000144218 AFF3 medulloblastoma sequence_alteration 4.167% (1/24) 1 entry
ENSG00000144218 AFF3 Extraskeletal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor missense_variant 3.704% (1/27) 1 entry
ENSG00000144218 AFF3 colon adenoma missense_variant 5.882% (1/17) 1 entry
ENSG00000144218 AFF3 clear cell renal carcinoma frameshift_variant 1.161% (16/1378) 1 entry
ENSG00000144218 AFF3 rectal adenocarcinoma stop_gained 1.357% (3/221) 1 entry
ENSG00000144218 AFF3 bronchoalveolar adenocarcinoma missense_variant 9.091% (2/22) 1 entry
ENSG00000144218 AFF3 T-cell acute lymphoblastic leukemia sequence_alteration 0.7895% (3/380) 1 entry
ENSG00000144218 AFF3 cecum adenocarcinoma frameshift_variant 3.053% (4/131) 1 entry
ENSG00000144218 AFF3 mucosal melanoma missense_variant 7.143% (1/14) 1 entry
ENSG00000144218 AFF3 Mantle cell lymphoma sequence_alteration 2.439% (1/41) 1 entry
ENSG00000144218 AFF3 T-cell acute lymphoblastic leukemia missense_variant 0.7895% (3/380) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000144218 AFF3 STAD 0.013 high
ENSG00000144218 AFF3 UVM 0.0047 low
ENSG00000144218 AFF3 PAAD 0.0017 low
ENSG00000144218 AFF3 UCEC 0.0038 high
ENSG00000144218 AFF3 THCA 0.037 high
ENSG00000144218 AFF3 ACC 0.00014 high
ENSG00000144218 AFF3 LUSC 0.0061 high
ENSG00000144218 AFF3 READ 0.042 high
ENSG00000144218 AFF3 KIRP 0.038 high
ENSG00000144218 AFF3 KICH 0.026 high
ENSG00000144218 AFF3 LUAD 0.015 low
ENSG00000144218 AFF3 PCPG 0.022 low
ENSG00000144218 AFF3 BRCA 0.0065 high
ENSG00000144218 AFF3 UCS 0.024 low
ENSG00000144218 AFF3 OV 0.049 high
ENSG00000144218 AFF3 BLCA 0.0041 high
ENSG00000144218 AFF3 SKCM 0.0015 high
ENSG00000144218 AFF3 CESC 0.0092 low
ENSG00000144218 AFF3 LIHC 0.00094 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency