Ensembl ID ENSG00000144048 Gene ID 8446 Accession 3066
Gene Symbol DUSP11 Alias PIR1 Full Name dual specificity phosphatase 11
Position 2 : 73761782 - 73780132 Length 18351 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

ENSG00000144048 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000144048 DUSP11 -0.9 1.52e-14 KICH
ENSG00000144048 DUSP11 0.87 5.12e-29 LUSC
ENSG00000144048 DUSP11 -0.6 1.49e-12 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000144048 DUSP11 Tumor 17164780
ENSG00000144048 DUSP11 cancer 30616319
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000144048 DUSP11 MESO 0.00074 high
ENSG00000144048 DUSP11 SARC 0.026 high
ENSG00000144048 DUSP11 STAD 0.0097 low
ENSG00000144048 DUSP11 CHOL 0.0076 high
ENSG00000144048 DUSP11 PAAD 0.0095 high
ENSG00000144048 DUSP11 UCEC 0.0089 high
ENSG00000144048 DUSP11 THCA 0.0018 low
ENSG00000144048 DUSP11 ACC 0.007 high
ENSG00000144048 DUSP11 LGG 0.0088 high
ENSG00000144048 DUSP11 LUSC 0.00056 low
ENSG00000144048 DUSP11 HNSC 0.00024 high
ENSG00000144048 DUSP11 KIRP 0.016 high
ENSG00000144048 DUSP11 KICH 0.045 high
ENSG00000144048 DUSP11 LUAD 0.016 high
ENSG00000144048 DUSP11 BRCA 0.00066 low
ENSG00000144048 DUSP11 COAD 0.037 high
ENSG00000144048 DUSP11 UCS 0.037 low
ENSG00000144048 DUSP11 OV 0.033 low
ENSG00000144048 DUSP11 DLBC 0.044 high
ENSG00000144048 DUSP11 KIRC 0.00012 low
ENSG00000144048 DUSP11 PRAD 0.0022 high
ENSG00000144048 DUSP11 SKCM 0.0031 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency