Ensembl ID ENSG00000143970 Gene ID 55252 Accession 23805
Gene Symbol ASXL2 Alias ASXH2;SHAPNS Full Name ASXL transcriptional regulator 2
Position 2 : 25733753 - 25878487 Length 144735 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutations in this gene are associated with cancer in several tissue types (breast, bladder, pancreas, ovary, prostate, and blood). This gene plays an important role in neurodevelopment, cardiac function, adipogenesis, and osteoclastogenesis. [provided by RefSeq, Feb 2017]

ENSG00000143970 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000143970 cancer 12888926
ENSG00000143970 cancer 15138607
ENSG00000143970 cancer 15375572
ENSG00000143970 colorectal cancers 23736028
ENSG00000143970 tumors 24121791
ENSG00000143970 cancer 25501392
ENSG00000143970 AML 26234722
ENSG00000143970 Cancer 26416890
ENSG00000143970 breast cancer 26640146
ENSG00000143970 AML 27470916
ENSG00000143970 cancer 27527698
ENSG00000143970 acute myeloid leukemia (AML) 27587249
ENSG00000143970 AMLs 27798625
ENSG00000143970 pediatric AML 28063196
ENSG00000143970 tumour 28516957
ENSG00000143970 tumour 28593990
ENSG00000143970 childhood AML 29270125
ENSG00000143970 Cancer 29284740
ENSG00000143970 AML 30093396
ENSG00000143970 AML 30135719
ENSG00000143970 cancer 30349006
ENSG00000143970 cancer 31221981
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000143970 prostate adenocarcinoma missense_variant 3.862% (83/2149) 3 entries
ENSG00000143970 prostate carcinoma sequence_alteration 3.756% (16/426) 3 entries
ENSG00000143970 cecum adenocarcinoma stop_gained 4.563% (12/263) 2 entries
ENSG00000143970 esophageal adenocarcinoma sequence_alteration 5.872% (32/545) 2 entries
ENSG00000143970 colorectal adenocarcinoma missense_variant 3.296% (38/1153) 3 entries
ENSG00000143970 melanoma conservative_inframe_deletion 9.655% (14/145) 1 entry
ENSG00000143970 head and neck squamous cell carcinoma sequence_alteration 0.4769% (3/629) 1 entry
ENSG00000143970 lung adenocarcinoma sequence_alteration 1.864% (47/2521) 6 entries
ENSG00000143970 gastric adenocarcinoma missense_variant 1.811% (13/718) 1 entry
ENSG00000143970 gastric intestinal type adenocarcinoma missense_variant 3.529% (3/85) 1 entry
ENSG00000143970 Mixed Lobular and Ductal Breast Carcinoma missense_variant 3.333% (2/60) 1 entry
ENSG00000143970 clear cell renal carcinoma sequence_alteration 1.534% (22/1434) 3 entries
ENSG00000143970 bladder transitional cell carcinoma missense_variant 4.251% (19/447) 3 entries
ENSG00000143970 cecum adenocarcinoma sequence_alteration 4.563% (12/263) 2 entries
ENSG00000143970 rectal adenocarcinoma sequence_alteration 2.752% (15/545) 2 entries
ENSG00000143970 esophageal squamous cell carcinoma missense_variant 1.316% (9/684) 4 entries
ENSG00000143970 bladder transitional cell carcinoma sequence_alteration 4.251% (19/447) 1 entry
ENSG00000143970 T-cell acute lymphoblastic leukemia sequence_alteration 1.575% (6/381) 1 entry
ENSG00000143970 bile duct adenocarcinoma missense_variant 1.305% (5/383) 1 entry
ENSG00000143970 Merkel cell skin cancer missense_variant 2.151% (2/93) 1 entry
ENSG00000143970 prostate carcinoma missense_variant 3.756% (16/426) 2 entries
ENSG00000143970 lung adenocarcinoma missense_variant 1.864% (47/2521) 7 entries
ENSG00000143970 female breast carcinoma sequence_alteration 2.996% (8/267) 1 entry
ENSG00000143970 pancreatic ductal adenocarcinoma sequence_alteration 4.096% (68/1660) 2 entries
ENSG00000143970 breast carcinoma missense_variant 1.425% (21/1474) 1 entry
ENSG00000143970 lung adenocarcinoma stop_gained 1.864% (47/2521) 2 entries
ENSG00000143970 clear cell renal carcinoma stop_gained 1.534% (22/1434) 1 entry
ENSG00000143970 T-cell acute lymphoblastic leukemia stop_gained 1.575% (6/381) 1 entry
ENSG00000143970 basal cell carcinoma missense_variant 19.12% (13/68) 2 entries
ENSG00000143970 Brain Stem Glioblastoma sequence_alteration 3.571% (2/56) 1 entry
ENSG00000143970 breast ductal adenocarcinoma stop_gained 5.092% (80/1571) 2 entries
ENSG00000143970 urothelial carcinoma missense_variant 4.651% (4/86) 1 entry
ENSG00000143970 melanoma stop_gained 9.655% (14/145) 2 entries
ENSG00000143970 colon adenocarcinoma missense_variant 2.318% (29/1251) 4 entries
ENSG00000143970 hepatocellular carcinoma missense_variant 1.22% (12/984) 2 entries
ENSG00000143970 urothelial carcinoma stop_gained 4.651% (4/86) 1 entry
ENSG00000143970 skin carcinoma sequence_alteration 5.769% (6/104) 1 entry
ENSG00000143970 skin melanoma sequence_alteration 3.365% (39/1159) 2 entries
ENSG00000143970 basal cell carcinoma sequence_alteration 19.12% (13/68) 2 entries
ENSG00000143970 prostate adenocarcinoma stop_gained 3.862% (83/2149) 2 entries
ENSG00000143970 skin melanoma stop_gained 3.365% (39/1159) 1 entry
ENSG00000143970 colorectal adenocarcinoma stop_gained 3.296% (38/1153) 2 entries
ENSG00000143970 T-cell acute lymphoblastic leukemia frameshift_variant 1.575% (6/381) 2 entries
ENSG00000143970 bladder transitional cell carcinoma stop_gained 4.251% (19/447) 1 entry
ENSG00000143970 melanoma missense_variant 9.655% (14/145) 3 entries
ENSG00000143970 squamous cell lung carcinoma missense_variant 1.073% (10/932) 1 entry
ENSG00000143970 gastric adenocarcinoma sequence_alteration 1.811% (13/718) 1 entry
ENSG00000143970 pancreatic ductal adenocarcinoma missense_variant 4.096% (68/1660) 2 entries
ENSG00000143970 cecum adenocarcinoma missense_variant 4.563% (12/263) 2 entries
ENSG00000143970 colon adenocarcinoma stop_gained 2.318% (29/1251) 2 entries
ENSG00000143970 head and neck squamous cell carcinoma missense_variant 0.4769% (3/629) 1 entry
ENSG00000143970 clear cell renal carcinoma missense_variant 1.534% (22/1434) 3 entries
ENSG00000143970 non-small cell lung carcinoma missense_variant 3.125% (3/96) 2 entries
ENSG00000143970 prostate adenocarcinoma frameshift_variant 3.862% (83/2149) 1 entry
ENSG00000143970 esophageal squamous cell carcinoma sequence_alteration 1.316% (9/684) 1 entry
ENSG00000143970 colon adenocarcinoma sequence_alteration 2.318% (29/1251) 4 entries
ENSG00000143970 female breast carcinoma missense_variant 2.996% (8/267) 2 entries
ENSG00000143970 Endometrial Endometrioid Adenocarcinoma stop_gained 3.87% (25/646) 1 entry
ENSG00000143970 ovarian serous adenocarcinoma sequence_alteration 0.3606% (3/832) 1 entry
ENSG00000143970 acute myeloid leukemia sequence_alteration 1.087% (11/1012) 1 entry
ENSG00000143970 small cell lung carcinoma missense_variant 2.273% (10/440) 2 entries
ENSG00000143970 prostate adenocarcinoma sequence_alteration 3.862% (83/2149) 3 entries
ENSG00000143970 brain glioblastoma frameshift_variant 0.5872% (7/1192) 1 entry
ENSG00000143970 oral squamous cell carcinoma sequence_alteration 1.136% (3/264) 2 entries
ENSG00000143970 cecum adenocarcinoma frameshift_variant 4.563% (12/263) 2 entries
ENSG00000143970 acute myeloid leukemia missense_variant 1.087% (11/1012) 1 entry
ENSG00000143970 Endometrial Endometrioid Adenocarcinoma missense_variant 3.87% (25/646) 1 entry
ENSG00000143970 small cell lung carcinoma sequence_alteration 2.273% (10/440) 2 entries
ENSG00000143970 rectal adenocarcinoma frameshift_variant 2.752% (15/545) 2 entries
ENSG00000143970 skin melanoma missense_variant 3.365% (39/1159) 2 entries
ENSG00000143970 esophageal adenocarcinoma missense_variant 5.872% (32/545) 2 entries
ENSG00000143970 oral squamous cell carcinoma missense_variant 1.136% (3/264) 3 entries
ENSG00000143970 brain glioblastoma missense_variant 0.5872% (7/1192) 1 entry
ENSG00000143970 bladder carcinoma missense_variant 5.348% (30/561) 1 entry
ENSG00000143970 skin melanoma conservative_inframe_deletion 3.365% (39/1159) 1 entry
ENSG00000143970 thyroid carcinoma missense_variant 0.54% (5/926) 1 entry
ENSG00000143970 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 2.02% (2/99) 1 entry
ENSG00000143970 chromophobe renal cell carcinoma frameshift_variant 2.041% (3/147) 1 entry
ENSG00000143970 breast ductal adenocarcinoma missense_variant 5.092% (80/1571) 2 entries
ENSG00000143970 colon adenocarcinoma frameshift_variant 2.318% (29/1251) 2 entries
ENSG00000143970 rectal adenocarcinoma missense_variant 2.752% (15/545) 3 entries
ENSG00000143970 melanoma sequence_alteration 9.655% (14/145) 2 entries
ENSG00000143970 pancreatic neuroendocrine tumor sequence_alteration 6.356% (15/236) 1 entry
ENSG00000143970 rectal adenocarcinoma stop_gained 2.752% (15/545) 2 entries
ENSG00000143970 pleomorphic liposarcoma missense_variant 22.22% (2/9) 2 entries
ENSG00000143970 colorectal adenocarcinoma sequence_alteration 3.296% (38/1153) 2 entries
ENSG00000143970 breast ductal adenocarcinoma sequence_alteration 5.092% (80/1571) 2 entries
ENSG00000143970 nasopharyngeal squamous cell carcinoma missense_variant 1.667% (3/180) 2 entries
ENSG00000143970 Uterine Carcinosarcoma sequence_alteration 2.703% (4/148) 1 entry
ENSG00000143970 Appendix Adenocarcinoma missense_variant 2.703% (2/74) 1 entry
ENSG00000143970 papillary renal cell carcinoma missense_variant 0.274% (1/365) 1 entry
ENSG00000143970 pancreatic neuroendocrine tumor missense_variant 6.356% (15/236) 1 entry
ENSG00000143970 female breast carcinoma frameshift_variant 2.996% (8/267) 1 entry
ENSG00000143970 Uterine Carcinosarcoma missense_variant 2.703% (4/148) 1 entry
ENSG00000143970 Ampulla of Vater Carcinoma sequence_alteration 1.176% (1/85) 1 entry
ENSG00000143970 colorectal adenocarcinoma frameshift_variant 3.296% (38/1153) 1 entry
ENSG00000143970 chronic lymphocytic leukemia frameshift_variant 1.122% (10/891) 1 entry
ENSG00000143970 neoplasm of mature B-cells missense_variant 1.667% (1/60) 1 entry
ENSG00000143970 Ovarian Granulosa Cell Tumor frameshift_variant 7.143% (1/14) 1 entry
ENSG00000143970 lobular breast carcinoma missense_variant 2.165% (5/231) 1 entry
ENSG00000143970 Uveal Melanoma missense_variant 0.7812% (1/128) 1 entry
ENSG00000143970 Gastrointestinal stromal tumor missense_variant 0.6757% (1/148) 1 entry
ENSG00000143970 Endometrial Endometrioid Adenocarcinoma frameshift_variant 3.87% (25/646) 1 entry
ENSG00000143970 breast ductal adenocarcinoma frameshift_variant 5.092% (80/1571) 1 entry
ENSG00000143970 Tonsillar Squamous Cell Carcinoma sequence_alteration 11.11% (1/9) 1 entry
ENSG00000143970 brain astrocytoma missense_variant 2.083% (1/48) 1 entry
ENSG00000143970 anaplastic astrocytoma missense_variant 0.7692% (1/130) 1 entry
ENSG00000143970 nasopharyngeal squamous cell carcinoma sequence_alteration 1.667% (3/180) 1 entry
ENSG00000143970 ependymoma sequence_alteration 1.852% (1/54) 1 entry
ENSG00000143970 unspecified peripheral T-cell lymphoma sequence_alteration 5.263% (1/19) 1 entry
ENSG00000143970 bladder carcinoma stop_gained 5.348% (30/561) 1 entry
ENSG00000143970 Breast Carcinoma by Gene Expression Profile missense_variant 5.263% (1/19) 1 entry
ENSG00000143970 Cortisol-Producing Adrenal Cortex Adenoma missense_variant 0.8065% (1/124) 1 entry
ENSG00000143970 undifferentiated pleomorphic sarcoma missense_variant 1.639% (1/61) 1 entry
ENSG00000143970 bladder transitional cell carcinoma frameshift_variant 4.251% (19/447) 1 entry
ENSG00000143970 diffuse gastric adenocarcinoma stop_gained 2.439% (2/82) 1 entry
ENSG00000143970 laryngeal squamous cell carcinoma missense_variant 2.439% (1/41) 1 entry
ENSG00000143970 salivary gland squamous cell carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000143970 colorectal adenoma sequence_alteration 11.11% (1/9) 1 entry
ENSG00000143970 bile duct adenocarcinoma stop_gained 1.305% (5/383) 1 entry
ENSG00000143970 brain glioblastoma sequence_alteration 0.5872% (7/1192) 1 entry
ENSG00000143970 bile duct adenocarcinoma frameshift_variant 1.305% (5/383) 1 entry
ENSG00000143970 Signet Ring Cell Gastric Adenocarcinoma frameshift_variant 50.0% (1/2) 1 entry
ENSG00000143970 colorectal adenoma missense_variant 11.11% (1/9) 1 entry
ENSG00000143970 diffuse gastric adenocarcinoma sequence_alteration 2.439% (2/82) 1 entry
ENSG00000143970 Pancreatic Acinar Cell Carcinoma missense_variant 2.941% (1/34) 1 entry
ENSG00000143970 Ampulla of Vater Carcinoma stop_gained 1.176% (1/85) 1 entry
ENSG00000143970 anaplastic oligodendroglioma missense_variant 1.176% (1/85) 1 entry
ENSG00000143970 Tonsillar Squamous Cell Carcinoma missense_variant 11.11% (1/9) 1 entry
ENSG00000143970 neoplasm of mature B-cells sequence_alteration 1.667% (1/60) 1 entry
ENSG00000143970 clear cell renal carcinoma frameshift_variant 1.534% (22/1434) 1 entry
ENSG00000143970 skin carcinoma missense_variant 5.769% (6/104) 1 entry
ENSG00000143970 chronic lymphocytic leukemia stop_gained 1.122% (10/891) 1 entry
ENSG00000143970 nasopharyngeal squamous cell carcinoma stop_gained 1.667% (3/180) 1 entry
ENSG00000143970 carcinoid tumor missense_variant 25.0% (1/4) 1 entry
ENSG00000143970 gastric intestinal type adenocarcinoma sequence_alteration 3.529% (3/85) 1 entry
ENSG00000143970 adenosquamous lung carcinoma missense_variant 4.545% (1/22) 1 entry
ENSG00000143970 unspecified peripheral T-cell lymphoma missense_variant 5.263% (1/19) 1 entry
ENSG00000143970 Signet Ring Cell Gastric Adenocarcinoma sequence_alteration 50.0% (1/2) 1 entry
ENSG00000143970 Pleural Epithelioid Mesothelioma missense_variant 0.7407% (1/135) 1 entry
ENSG00000143970 ovarian serous adenocarcinoma missense_variant 0.3606% (3/832) 1 entry
ENSG00000143970 colon adenocarcinoma conservative_inframe_deletion 2.318% (29/1251) 1 entry
ENSG00000143970 bronchoalveolar adenocarcinoma missense_variant 4.545% (1/22) 1 entry
ENSG00000143970 Duodenal Adenocarcinoma missense_variant 5.882% (1/17) 1 entry
ENSG00000143970 colorectal adenocarcinoma conservative_inframe_deletion 3.296% (38/1153) 1 entry
ENSG00000143970 squamous cell lung carcinoma stop_gained 1.073% (10/932) 1 entry
ENSG00000143970 anaplastic oligodendroglioma sequence_alteration 1.176% (1/85) 1 entry
ENSG00000143970 Major Salivary Gland Carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000143970 prostate carcinoma frameshift_variant 3.756% (16/426) 1 entry
ENSG00000143970 Appendix Adenocarcinoma sequence_alteration 2.703% (2/74) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000143970 PAAD 0.0037 high
ENSG00000143970 UCEC 0.0098 high
ENSG00000143970 ACC 0.045 high
ENSG00000143970 LUSC 0.028 high
ENSG00000143970 HNSC 0.016 low
ENSG00000143970 READ 0.042 low
ENSG00000143970 KIRP 0.028 high
ENSG00000143970 BRCA 0.049 high
ENSG00000143970 ESCA 0.029 low
ENSG00000143970 OV 0.024 high
ENSG00000143970 DLBC 0.024 high
ENSG00000143970 BLCA 0.017 high
ENSG00000143970 GBM 0.043 low
ENSG00000143970 SKCM 0.017 low
ENSG00000143970 CESC 0.015 high
ENSG00000143970 LIHC 0.039 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000143970 TGCT Amp 1.969747 0.177402 0.450564 0.406667
ENSG00000143970 UCEC Amp 0.874150 0.107470 0.591660 0.213358