Ensembl ID ENSG00000143870 Gene ID 10130 Accession 30168
Gene Symbol PDIA6 Alias P5;ERP5;TXNDC7 Full Name protein disulfide isomerase family A member 6
Position 2 : 10783391 - 10837977 Length 54587 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

ENSG00000143870 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000143870 0.64 1.90e-19 BRCA
ENSG00000143870 1.17 1.60e-40 LUSC
ENSG00000143870 0.98 3.96e-11 UCEC
ENSG00000143870 1.03 1.17e-27 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000143870 breast cancer 17420453
ENSG00000143870 tumour 17495932
ENSG00000143870 tumor 19008459
ENSG00000143870 cancers 20623638
ENSG00000143870 tumor 21649721
ENSG00000143870 tumor 22215138
ENSG00000143870 cancer 23977302
ENSG00000143870 cancer 24464223
ENSG00000143870 cancer 24920482
ENSG00000143870 breast cancer 26125904
ENSG00000143870 giant cell tumor of bone 26655997
ENSG00000143870 cancer 27462866
ENSG00000143870 Bladder Cancer 27760590
ENSG00000143870 tumor 28866093
ENSG00000143870 ovarian cancer 29262583
ENSG00000143870 tumor 30288659
ENSG00000143870 non-small cell lung cancer 30922965
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000143870 MESO 0.0034 high
ENSG00000143870 SARC 0.0016 high
ENSG00000143870 UVM 0.013 high
ENSG00000143870 PAAD 0.007 high
ENSG00000143870 THCA 0.015 high
ENSG00000143870 READ 0.049 low
ENSG00000143870 PCPG 0.021 low
ENSG00000143870 UCS 0.043 low
ENSG00000143870 ESCA 0.025 low
ENSG00000143870 OV 0.016 low
ENSG00000143870 KIRC 0.0021 low
ENSG00000143870 TGCT 0.039 high
ENSG00000143870 BLCA 0.0039 high
ENSG00000143870 LAML 0.0018 low
ENSG00000143870 GBM 0.021 high
ENSG00000143870 SKCM 0.012 low
ENSG00000143870 CESC 0.00018 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000143870 LIHC Amp 1.403237 0.131893 0.526835 0.175676
ENSG00000143870 TGCT Amp 1.690985 0.162419 0.462090 0.380000