Ensembl ID ENSG00000143815 Gene ID 3930 Accession 6518
Gene Symbol LBR Alias PHA;C14SR;LMN2R;PHASK;TDRD18;DHCR14B Full Name lamin B receptor
Position 1 : 225401502 - 225428925 Length 27424 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

ENSG00000143815 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000143815 LBR -2.0 2.30e-28 KICH
ENSG00000143815 LBR 0.73 4.43e-15 LUSC
ENSG00000143815 LBR 0.56 2.52e-13 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000143815 LBR tumor 11507061
ENSG00000143815 LBR ovarian tumor 17923740
ENSG00000143815 LBR breast cancer 24293108
ENSG00000143815 LBR cancer 24637400
ENSG00000143815 LBR tumor 27336722
ENSG00000143815 LBR cancer 27760841
ENSG00000143815 LBR cancer 28858257
ENSG00000143815 LBR cancer 29415520
ENSG00000143815 LBR colon cancer 30155352
ENSG00000143815 LBR cancer 30982228
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000143815 LBR MESO 0.01 high
ENSG00000143815 LBR UVM 0.00021 high
ENSG00000143815 LBR PAAD 0.031 high
ENSG00000143815 LBR UCEC 0.011 low
ENSG00000143815 LBR THCA 0.0021 high
ENSG00000143815 LBR HNSC 0.0073 high
ENSG00000143815 LBR READ 0.028 low
ENSG00000143815 LBR KIRP 0.005 high
ENSG00000143815 LBR LUAD 0.0026 high
ENSG00000143815 LBR PCPG 0.0068 high
ENSG00000143815 LBR COAD 0.0061 low
ENSG00000143815 LBR ESCA 0.0064 high
ENSG00000143815 LBR KIRC 0.048 low
ENSG00000143815 LBR LAML 0.00021 low
ENSG00000143815 LBR SKCM 0.0015 low
ENSG00000143815 LBR CESC 0.031 low
ENSG00000143815 LBR LIHC 0.00084 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000143815 LBR SARC Del 6.057406 0.234223 0.483632 0.338521
ENSG00000143815 LBR GBM Del 1.091102 0.057041 0.443537 0.076256
ENSG00000143815 LBR SKCM Amp 0.738218 0.120776 0.691986 0.504087
ENSG00000143815 LBR LIHC Amp 2.957354 0.166909 0.835503 0.708108
ENSG00000143815 LBR DLBC Del 1.261269 0.155631 0.558317 0.145833
ENSG00000143815 LBR BRCA Amp 10.474785 0.269320 0.788147 0.746296
ENSG00000143815 LBR PRAD Del 0.945820 0.075257 0.493947 0.077236
ENSG00000143815 LBR UCEC Amp 1.618744 0.125254 0.835334 0.419295
ENSG00000143815 LBR KIRC Del 0.682869 0.024196 0.455284 0.079545
ENSG00000143815 LBR OV Amp 3.610273 0.418697 0.717255 0.521589