Ensembl ID ENSG00000143748 Gene ID 4931 Accession 8070
Gene Symbol NVL Alias NVL2 Full Name nuclear VCP like
Position 1 : 224227334 - 224330189 Length 102856 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]

ENSG00000143748 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000143748 NVL 0.49 4.46e-18 HNSC
ENSG00000143748 NVL 1.33 4.35e-89 BRCA
ENSG00000143748 NVL 0.64 7.17e-28 LUSC
ENSG00000143748 NVL 0.97 5.64e-37 LIHC
ENSG00000143748 NVL 0.77 1.14e-36 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000143748 NVL cancer 22226966
ENSG00000143748 NVL prostate cancer 26631616
ENSG00000143748 NVL prostate cancer 27728977
ENSG00000143748 NVL cancer 30705282
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000143748 NVL MESO 0.0057 high
ENSG00000143748 NVL SARC 0.033 low
ENSG00000143748 NVL UVM 0.041 high
ENSG00000143748 NVL LUSC 0.00092 low
ENSG00000143748 NVL HNSC 0.029 low
ENSG00000143748 NVL KICH 0.0017 high
ENSG00000143748 NVL LUAD 0.0018 low
ENSG00000143748 NVL COAD 0.0073 high
ENSG00000143748 NVL ESCA 0.0087 high
ENSG00000143748 NVL OV 0.049 low
ENSG00000143748 NVL DLBC 0.016 high
ENSG00000143748 NVL SKCM 0.0094 high
ENSG00000143748 NVL LIHC 0.00016 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000143748 NVL SARC Del 6.109156 0.235066 0.482844 0.338521
ENSG00000143748 NVL GBM Del 2.979959 0.076555 0.477331 0.081456
ENSG00000143748 NVL SKCM Amp 1.145649 0.134993 0.702798 0.504087
ENSG00000143748 NVL LIHC Amp 3.000947 0.168167 0.839883 0.710811
ENSG00000143748 NVL DLBC Del 1.262726 0.155631 0.558317 0.145833
ENSG00000143748 NVL BRCA Amp 12.666493 0.289267 0.799497 0.748148
ENSG00000143748 NVL UCEC Amp 2.214455 0.137146 0.861384 0.413729
ENSG00000143748 NVL KIRC Del 0.693182 0.024196 0.455223 0.079545
ENSG00000143748 NVL OV Amp 1.989895 0.374076 0.699350 0.506045