Ensembl ID ENSG00000143621 Gene ID 3608 Accession 6037
Gene Symbol ILF2 Alias NF45;PRO3063 Full Name interleukin enhancer binding factor 2
Position 1 : 153661788 - 153671028 Length 9241 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

ENSG00000143621 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000143621 ILF2 0.98 6.92e-58 BRCA
ENSG00000143621 ILF2 0.63 7.33e-18 COAD
ENSG00000143621 ILF2 -0.9 2.52e-25 KICH
ENSG00000143621 ILF2 1.18 1.16e-49 LUSC
ENSG00000143621 ILF2 0.94 2.04e-35 LIHC
ENSG00000143621 ILF2 1.13 2.91e-33 UCEC
ENSG00000143621 ILF2 1.13 9.86e-13 CHOL
ENSG00000143621 ILF2 1.05 4.25e-36 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000143621 ILF2 cancer 23799036
ENSG00000143621 ILF2 tumor 24120475
ENSG00000143621 ILF2 tumor 25023405
ENSG00000143621 ILF2 cancer 25286760
ENSG00000143621 ILF2 non-small cell lung cancer 26059795
ENSG00000143621 ILF2 cancer 26276310
ENSG00000143621 ILF2 tumor 26573128
ENSG00000143621 ILF2 tumor 27519414
ENSG00000143621 ILF2 tumor 27556459
ENSG00000143621 ILF2 tumor 28259961
ENSG00000143621 ILF2 Gastric Cancer 28831206
ENSG00000143621 ILF2 cervical cancer 29218240
ENSG00000143621 ILF2 gastric cancer 29328366
ENSG00000143621 ILF2 cervical cancer 29449553
ENSG00000143621 ILF2 breast cancer 30018709
ENSG00000143621 ILF2 Liver Cancer 30881868
ENSG00000143621 ILF2 cancers 31022259
ENSG00000143621 ILF2 cancer 31227749
ENSG00000143621 ILF2 lung cancer 31423236
ENSG00000143621 ILF2 lung tumor 31619507
ENSG00000143621 ILF2 small cell lung cancer 31908894
ENSG00000143621 ILF2 cervical cancer 9865919
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000143621 ILF2 MESO 0.0062 high
ENSG00000143621 ILF2 UVM 0.012 high
ENSG00000143621 ILF2 PAAD 0.02 high
ENSG00000143621 ILF2 UCEC 0.021 high
ENSG00000143621 ILF2 LGG 0.0034 high
ENSG00000143621 ILF2 KIRP 0.00015 high
ENSG00000143621 ILF2 KICH 0.03 high
ENSG00000143621 ILF2 PCPG 0.0032 high
ENSG00000143621 ILF2 THYM 0.00051 low
ENSG00000143621 ILF2 BRCA 0.0014 high
ENSG00000143621 ILF2 COAD 0.044 low
ENSG00000143621 ILF2 UCS 0.0017 low
ENSG00000143621 ILF2 ESCA 0.011 high
ENSG00000143621 ILF2 OV 0.0016 low
ENSG00000143621 ILF2 DLBC 0.0025 low
ENSG00000143621 ILF2 KIRC 0.0036 high
ENSG00000143621 ILF2 TGCT 0.029 high
ENSG00000143621 ILF2 GBM 0.0084 low
ENSG00000143621 ILF2 SKCM 0.0025 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000143621 ILF2 CHOL Amp 0.963900 0.488645 1.029314 0.611111
ENSG00000143621 ILF2 LUSC Amp 3.550030 0.274817 0.549801 0.528942
ENSG00000143621 ILF2 LUAD Amp 20.529843 0.401167 0.606450 0.742248
ENSG00000143621 ILF2 CESC Amp 2.712063 0.201679 0.621250 0.532203
ENSG00000143621 ILF2 READ Amp 1.357261 0.159213 0.625018 0.284848
ENSG00000143621 ILF2 UCS Amp 1.210105 0.577532 0.775916 0.678571
ENSG00000143621 ILF2 SARC Amp 5.930459 0.487360 0.756206 0.404669
ENSG00000143621 ILF2 ESCA Amp 0.727737 0.261147 0.491940 0.494565
ENSG00000143621 ILF2 SKCM Amp 3.779915 0.211287 0.692757 0.550409
ENSG00000143621 ILF2 LIHC Amp 19.435658 0.420289 0.909101 0.751351
ENSG00000143621 ILF2 PCPG Amp 3.268801 0.126992 0.702489 0.179012
ENSG00000143621 ILF2 TGCT Amp 0.843213 0.123321 0.448530 0.453333
ENSG00000143621 ILF2 DLBC Amp 0.878931 0.205051 0.637954 0.229167
ENSG00000143621 ILF2 BLCA Amp 12.434869 0.434060 0.618245 0.477941
ENSG00000143621 ILF2 BRCA Amp 20.761959 0.355251 0.791759 0.722222
ENSG00000143621 ILF2 STAD Amp 3.660864 0.209190 0.488281 0.369615
ENSG00000143621 ILF2 PRAD Amp 1.748114 0.060651 0.565908 0.079268
ENSG00000143621 ILF2 UCEC Amp 10.917535 0.257266 0.897054 0.443414
ENSG00000143621 ILF2 OV Amp 12.956799 0.594971 0.743954 0.620035