Ensembl ID ENSG00000143575 Gene ID 10456 Accession 16915
Gene Symbol HAX1 Alias SCN3;HS1BP1;HCLSBP1 Full Name HCLS1 associated protein X-1
Position 1 : 154272355 - 154275875 Length 3521 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000143575 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000143575 HAX1 0.56 3.67e-27 BRCA
ENSG00000143575 HAX1 0.63 1.14e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000143575 HAX1 oral cancer 17545607
ENSG00000143575 HAX1 tumors 20196840
ENSG00000143575 HAX1 breast cancer 20696135
ENSG00000143575 HAX1 cancer 21302289
ENSG00000143575 HAX1 breast cancer 21567072
ENSG00000143575 HAX1 cancer 22315598
ENSG00000143575 HAX1 tumor 22451114
ENSG00000143575 HAX1 ovarian cancer 23377018
ENSG00000143575 HAX1 tumor 23405089
ENSG00000143575 HAX1 tumors 23531395
ENSG00000143575 HAX1 breast cancer 23792445
ENSG00000143575 HAX1 colorectal cancer 24057929
ENSG00000143575 HAX1 cancer 25275296
ENSG00000143575 HAX1 tumor 25419709
ENSG00000143575 HAX1 tumor 25554539
ENSG00000143575 HAX1 tumor 25767605
ENSG00000143575 HAX1 tumor 26062578
ENSG00000143575 HAX1 prostate cancer 26323553
ENSG00000143575 HAX1 tumor 26871467
ENSG00000143575 HAX1 breast cancer 26885017
ENSG00000143575 HAX1 colorectal cancer 27506941
ENSG00000143575 HAX1 Triple-Negative Breast Cancer 27618431
ENSG00000143575 HAX1 laryngeal cancer 27880721
ENSG00000143575 HAX1 cancer 27943080
ENSG00000143575 HAX1 breast cancer 28347249
ENSG00000143575 HAX1 tumor 28791389
ENSG00000143575 HAX1 malignant tumors 29139175
ENSG00000143575 HAX1 malignant tumors 29311840
ENSG00000143575 HAX1 breast cancer 29434858
ENSG00000143575 HAX1 Breast Cancer 29975932
ENSG00000143575 HAX1 cancer 30013658
ENSG00000143575 HAX1 tumor 31047882
ENSG00000143575 HAX1 Breast Cancer 31093284
ENSG00000143575 HAX1 liver cancer 31132019
ENSG00000143575 HAX1 breast cancer 31644363
ENSG00000143575 HAX1 tumor 31938315
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000143575 HAX1 MESO 0.035 high
ENSG00000143575 HAX1 SARC 0.001 low
ENSG00000143575 HAX1 PAAD 0.0077 low
ENSG00000143575 HAX1 ACC 0.0072 high
ENSG00000143575 HAX1 HNSC 0.017 high
ENSG00000143575 HAX1 READ 0.045 high
ENSG00000143575 HAX1 KIRP 0.003 high
ENSG00000143575 HAX1 PCPG 0.019 high
ENSG00000143575 HAX1 THYM 0.034 high
ENSG00000143575 HAX1 BRCA 0.02 low
ENSG00000143575 HAX1 UCS 0.0091 low
ENSG00000143575 HAX1 ESCA 0.0042 high
ENSG00000143575 HAX1 OV 0.0084 low
ENSG00000143575 HAX1 LAML 0.013 high
ENSG00000143575 HAX1 GBM 0.048 low
ENSG00000143575 HAX1 SKCM 0.0017 high
ENSG00000143575 HAX1 LIHC 0.00063 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000143575 HAX1 CHOL Amp 1.106022 0.534678 1.013955 0.638889
ENSG00000143575 HAX1 LUSC Amp 3.387724 0.271032 0.548578 0.526946
ENSG00000143575 HAX1 LUAD Amp 20.044610 0.395907 0.605848 0.742248
ENSG00000143575 HAX1 CESC Amp 2.712063 0.201679 0.621250 0.532203
ENSG00000143575 HAX1 SARC Amp 4.375042 0.430812 0.724089 0.389105
ENSG00000143575 HAX1 SKCM Amp 3.767482 0.210940 0.685532 0.553134
ENSG00000143575 HAX1 LIHC Amp 17.991080 0.397228 0.904559 0.748649
ENSG00000143575 HAX1 PCPG Amp 3.268801 0.113313 0.695367 0.172840
ENSG00000143575 HAX1 TGCT Amp 0.658729 0.114210 0.441408 0.460000
ENSG00000143575 HAX1 DLBC Amp 1.306895 0.247389 0.653875 0.250000
ENSG00000143575 HAX1 BLCA Amp 10.394212 0.397001 0.599651 0.465686
ENSG00000143575 HAX1 BRCA Amp 21.068975 0.357521 0.785999 0.730556
ENSG00000143575 HAX1 STAD Amp 2.332161 0.178388 0.469591 0.362812
ENSG00000143575 HAX1 PRAD Amp 2.645596 0.072304 0.621479 0.081301
ENSG00000143575 HAX1 UCEC Amp 7.725586 0.219242 0.865348 0.441558
ENSG00000143575 HAX1 OV Amp 8.229992 0.515072 0.708621 0.604491