Ensembl ID ENSG00000143379 Gene ID 9869 Accession 10761
Gene Symbol SETDB1 Alias ESET;KG1T;KMT1E;TDRD21;H3-K9-HMTase4 Full Name SET domain bifurcated histone lysine methyltransferase 1
Position 1 : 150926263 - 150964744 Length 38482 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]

ENSG00000143379 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000143379 SETDB1 0.49 9.79e-37 KIRC
ENSG00000143379 SETDB1 0.49 1.70e-24 BRCA
ENSG00000143379 SETDB1 0.75 3.29e-20 LIHC
ENSG00000143379 SETDB1 0.51 8.53e-11 STAD
ENSG00000143379 SETDB1 0.63 6.29e-20 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000143379 SETDB1 cancer 16682412
ENSG00000143379 SETDB1 Tumor 21430779
ENSG00000143379 SETDB1 tumor 22022377
ENSG00000143379 SETDB1 colon cancer 22863622
ENSG00000143379 SETDB1 cancer 23770855
ENSG00000143379 SETDB1 lung cancer 23933322
ENSG00000143379 SETDB1 cancer 23935871
ENSG00000143379 SETDB1 prostate cancer 24556744
ENSG00000143379 SETDB1 tumor 24658378
ENSG00000143379 SETDB1 tumor 24844570
ENSG00000143379 SETDB1 cancer 24874471
ENSG00000143379 SETDB1 breast cancer 25070049
ENSG00000143379 SETDB1 tumors 25123191
ENSG00000143379 SETDB1 tumour 25404354
ENSG00000143379 SETDB1 lung cancer 25477335
ENSG00000143379 SETDB1 breast cancers 25537518
ENSG00000143379 SETDB1 tumor 25587943
ENSG00000143379 SETDB1 astrocytic tumors 25602259
ENSG00000143379 SETDB1 tumour 26471002
ENSG00000143379 SETDB1 cancer 26481868
ENSG00000143379 SETDB1 Non-Small-Cell Lung Cancer 26536195
ENSG00000143379 SETDB1 non-small cell lung cancer 26542178
ENSG00000143379 SETDB1 lung cancer 26824986
ENSG00000143379 SETDB1 breast cancer 26840455
ENSG00000143379 SETDB1 cancer 26998265
ENSG00000143379 SETDB1 cancers 27551509
ENSG00000143379 SETDB1 cancers 27572307
ENSG00000143379 SETDB1 cancer 28076698
ENSG00000143379 SETDB1 cancers 28887438
ENSG00000143379 SETDB1 tumor 28913972
ENSG00000143379 SETDB1 Cancer 29066607
ENSG00000143379 SETDB1 lung cancer 29108991
ENSG00000143379 SETDB1 tumor 29109980
ENSG00000143379 SETDB1 Colorectal Cancer 29158805
ENSG00000143379 SETDB1 cancer 29177029
ENSG00000143379 SETDB1 cancer 29233829
ENSG00000143379 SETDB1 cancer 29492189
ENSG00000143379 SETDB1 tumors 29739365
ENSG00000143379 SETDB1 prostate cancer 29888169
ENSG00000143379 SETDB1 cancers 29897144
ENSG00000143379 SETDB1 cancer 29901162
ENSG00000143379 SETDB1 breast cancer 29926931
ENSG00000143379 SETDB1 non-small cell lung cancer 30054425
ENSG00000143379 SETDB1 tumors 30061297
ENSG00000143379 SETDB1 colorectal cancer 30105513
ENSG00000143379 SETDB1 germ cell tumor 30297796
ENSG00000143379 SETDB1 tumor 30309377
ENSG00000143379 SETDB1 breast cancer 30483750
ENSG00000143379 SETDB1 Tumor 30503969
ENSG00000143379 SETDB1 cancer 30545440
ENSG00000143379 SETDB1 cancers 30692625
ENSG00000143379 SETDB1 cancer 30692626
ENSG00000143379 SETDB1 cancer 30850015
ENSG00000143379 SETDB1 cancers 31050579
ENSG00000143379 SETDB1 tumors 31086817
ENSG00000143379 SETDB1 tumors 31131878
ENSG00000143379 SETDB1 tumor 31137727
ENSG00000143379 SETDB1 breast cancer 31137748
ENSG00000143379 SETDB1 cancers 31245293
ENSG00000143379 SETDB1 Colorectal Cancer 31306481
ENSG00000143379 SETDB1 cancers 31327677
ENSG00000143379 SETDB1 lung cancer 31341405
ENSG00000143379 SETDB1 Non-Small Cell Lung Cancer 31398867
ENSG00000143379 SETDB1 tumor 31405032
ENSG00000143379 SETDB1 hematopoietic tumors 31422102
ENSG00000143379 SETDB1 cancer 31428579
ENSG00000143379 SETDB1 tumor 31686850
ENSG00000143379 SETDB1 breast cancer 31735020
ENSG00000143379 SETDB1 cancer 31768101
ENSG00000143379 SETDB1 Colorectal Cancer 31896605
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000143379 SETDB1 papillary renal cell carcinoma missense_variant 0.597% (2/335) 1 entry
ENSG00000143379 SETDB1 diffuse large B-cell lymphoma sequence_alteration 0.9901% (3/303) 1 entry
ENSG00000143379 SETDB1 breast carcinoma missense_variant 1.559% (22/1411) 1 entry
ENSG00000143379 SETDB1 hepatocellular carcinoma missense_variant 0.6659% (6/901) 1 entry
ENSG00000143379 SETDB1 Merkel cell skin cancer missense_variant 6.667% (2/30) 1 entry
ENSG00000143379 SETDB1 Pleural Epithelioid Mesothelioma frameshift_variant 0.9569% (2/209) 1 entry
ENSG00000143379 SETDB1 diffuse gastric adenocarcinoma frameshift_variant 3.797% (3/79) 1 entry
ENSG00000143379 SETDB1 Pleural Mesothelioma sequence_alteration 6.731% (7/104) 1 entry
ENSG00000143379 SETDB1 colon adenocarcinoma missense_variant 2.909% (21/722) 6 entries
ENSG00000143379 SETDB1 clear cell renal carcinoma missense_variant 0.7752% (10/1290) 1 entry
ENSG00000143379 SETDB1 esophageal adenocarcinoma missense_variant 2.055% (9/438) 1 entry
ENSG00000143379 SETDB1 squamous cell lung carcinoma missense_variant 1.05% (8/762) 1 entry
ENSG00000143379 SETDB1 prostate adenocarcinoma frameshift_variant 1.307% (19/1454) 1 entry
ENSG00000143379 SETDB1 esophageal squamous cell carcinoma missense_variant 1.037% (7/675) 1 entry
ENSG00000143379 SETDB1 squamous cell lung carcinoma sequence_alteration 1.05% (8/762) 1 entry
ENSG00000143379 SETDB1 rectal adenocarcinoma missense_variant 2.715% (6/221) 2 entries
ENSG00000143379 SETDB1 lung adenocarcinoma missense_variant 0.8598% (10/1163) 3 entries
ENSG00000143379 SETDB1 colorectal adenocarcinoma sequence_alteration 5.009% (57/1138) 3 entries
ENSG00000143379 SETDB1 female breast carcinoma missense_variant 1.873% (5/267) 1 entry
ENSG00000143379 SETDB1 colon adenocarcinoma frameshift_variant 2.909% (21/722) 1 entry
ENSG00000143379 SETDB1 colorectal adenocarcinoma stop_gained 5.009% (57/1138) 1 entry
ENSG00000143379 SETDB1 diffuse large B-cell lymphoma missense_variant 0.9901% (3/303) 2 entries
ENSG00000143379 SETDB1 cecum adenocarcinoma missense_variant 5.6% (7/125) 1 entry
ENSG00000143379 SETDB1 Sarcomatoid Mesothelioma stop_gained 100.0% (2/2) 1 entry
ENSG00000143379 SETDB1 colorectal adenocarcinoma missense_variant 5.009% (57/1138) 3 entries
ENSG00000143379 SETDB1 Pleural Mesothelioma frameshift_variant 6.731% (7/104) 1 entry
ENSG00000143379 SETDB1 prostate carcinoma sequence_alteration 2.113% (9/426) 1 entry
ENSG00000143379 SETDB1 esophageal adenocarcinoma sequence_alteration 2.055% (9/438) 1 entry
ENSG00000143379 SETDB1 skin melanoma missense_variant 1.138% (11/967) 1 entry
ENSG00000143379 SETDB1 skin melanoma stop_gained 1.138% (11/967) 1 entry
ENSG00000143379 SETDB1 prostate carcinoma missense_variant 2.113% (9/426) 1 entry
ENSG00000143379 SETDB1 Pleural Mesothelioma missense_variant 6.731% (7/104) 1 entry
ENSG00000143379 SETDB1 gastric adenocarcinoma missense_variant 2.688% (15/558) 2 entries
ENSG00000143379 SETDB1 lung adenocarcinoma sequence_alteration 0.8598% (10/1163) 3 entries
ENSG00000143379 SETDB1 clear cell renal carcinoma sequence_alteration 0.7752% (10/1290) 1 entry
ENSG00000143379 SETDB1 diffuse gastric adenocarcinoma sequence_alteration 3.797% (3/79) 1 entry
ENSG00000143379 SETDB1 colon adenocarcinoma sequence_alteration 2.909% (21/722) 3 entries
ENSG00000143379 SETDB1 ovarian serous adenocarcinoma missense_variant 0.4458% (3/673) 1 entry
ENSG00000143379 SETDB1 colorectal adenocarcinoma frameshift_variant 5.009% (57/1138) 2 entries
ENSG00000143379 SETDB1 female breast carcinoma sequence_alteration 1.873% (5/267) 1 entry
ENSG00000143379 SETDB1 basal cell carcinoma sequence_alteration 3.448% (2/58) 1 entry
ENSG00000143379 SETDB1 prostate adenocarcinoma missense_variant 1.307% (19/1454) 2 entries
ENSG00000143379 SETDB1 gastric intestinal type adenocarcinoma missense_variant 3.529% (3/85) 1 entry
ENSG00000143379 SETDB1 gastric adenocarcinoma sequence_alteration 2.688% (15/558) 1 entry
ENSG00000143379 SETDB1 osteosarcoma sequence_alteration 1.724% (2/116) 1 entry
ENSG00000143379 SETDB1 chronic lymphocytic leukemia missense_variant 0.7883% (7/888) 1 entry
ENSG00000143379 SETDB1 HER2 Positive Breast Carcinoma sequence_alteration 3.704% (4/108) 1 entry
ENSG00000143379 SETDB1 breast carcinoma conservative_inframe_deletion 1.559% (22/1411) 1 entry
ENSG00000143379 SETDB1 lobular breast carcinoma missense_variant 2.778% (1/36) 1 entry
ENSG00000143379 SETDB1 rectal adenocarcinoma stop_gained 2.715% (6/221) 1 entry
ENSG00000143379 SETDB1 Pleural Mesothelioma conservative_inframe_deletion 6.731% (7/104) 1 entry
ENSG00000143379 SETDB1 gastric adenocarcinoma frameshift_variant 2.688% (15/558) 1 entry
ENSG00000143379 SETDB1 prostate carcinoma stop_gained 2.113% (9/426) 1 entry
ENSG00000143379 SETDB1 Pleural Biphasic Mesothelioma stop_gained 5.333% (4/75) 1 entry
ENSG00000143379 SETDB1 Pleural Sarcomatoid Mesothelioma frameshift_variant 15.38% (2/13) 1 entry
ENSG00000143379 SETDB1 Pleural Biphasic Mesothelioma missense_variant 5.333% (4/75) 1 entry
ENSG00000143379 SETDB1 kidney Wilms tumor missense_variant 0.3135% (1/319) 1 entry
ENSG00000143379 SETDB1 Pleural Mesothelioma stop_gained 6.731% (7/104) 1 entry
ENSG00000143379 SETDB1 adenosquamous lung carcinoma missense_variant 9.091% (1/11) 1 entry
ENSG00000143379 SETDB1 HER2 Positive Breast Carcinoma missense_variant 3.704% (4/108) 1 entry
ENSG00000143379 SETDB1 Pleural Biphasic Mesothelioma frameshift_variant 5.333% (4/75) 1 entry
ENSG00000143379 SETDB1 neoplasm missense_variant 3.571% (1/28) 1 entry
ENSG00000143379 SETDB1 chronic lymphocytic leukemia stop_gained 0.7883% (7/888) 1 entry
ENSG00000143379 SETDB1 cecum adenocarcinoma stop_gained 5.6% (7/125) 1 entry
ENSG00000143379 SETDB1 clear cell renal carcinoma frameshift_variant 0.7752% (10/1290) 1 entry
ENSG00000143379 SETDB1 prostate carcinoma stop_lost 2.113% (9/426) 1 entry
ENSG00000143379 SETDB1 bronchoalveolar adenocarcinoma missense_variant 4.545% (1/22) 1 entry
ENSG00000143379 SETDB1 oral squamous cell carcinoma missense_variant 0.4854% (1/206) 1 entry
ENSG00000143379 SETDB1 melanoma missense_variant 0.9901% (1/101) 1 entry
ENSG00000143379 SETDB1 colonic neoplasm missense_variant 6.667% (1/15) 1 entry
ENSG00000143379 SETDB1 Fallopian Tube Serous Adenocarcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000143379 SETDB1 adrenal cortex carcinoma missense_variant 0.6098% (1/164) 1 entry
ENSG00000143379 SETDB1 Malignant Germ Cell Tumor missense_variant 100.0% (1/1) 1 entry
ENSG00000143379 SETDB1 angiosarcoma sequence_alteration 7.692% (1/13) 1 entry
ENSG00000143379 SETDB1 Malignant Germ Cell Tumor sequence_alteration 100.0% (1/1) 1 entry
ENSG00000143379 SETDB1 Pleural Sarcomatoid Mesothelioma sequence_alteration 15.38% (2/13) 1 entry
ENSG00000143379 SETDB1 bladder transitional cell carcinoma missense_variant 0.7299% (1/137) 1 entry
ENSG00000143379 SETDB1 oral squamous cell carcinoma sequence_alteration 0.4854% (1/206) 1 entry
ENSG00000143379 SETDB1 ovarian carcinoma missense_variant 16.67% (1/6) 1 entry
ENSG00000143379 SETDB1 Pleural Biphasic Mesothelioma sequence_alteration 5.333% (4/75) 1 entry
ENSG00000143379 SETDB1 testicular seminoma missense_variant 7.692% (1/13) 1 entry
ENSG00000143379 SETDB1 nasopharyngeal squamous cell carcinoma stop_gained 0.4184% (1/239) 1 entry
ENSG00000143379 SETDB1 diffuse gastric adenocarcinoma stop_gained 3.797% (3/79) 1 entry
ENSG00000143379 SETDB1 Pleural Sarcomatoid Mesothelioma stop_gained 15.38% (2/13) 1 entry
ENSG00000143379 SETDB1 Gallbladder Adenocarcinoma missense_variant 1.149% (1/87) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000143379 SETDB1 SARC 0.042 high
ENSG00000143379 SETDB1 UVM 0.045 low
ENSG00000143379 SETDB1 UCEC 0.0016 high
ENSG00000143379 SETDB1 THCA 0.0083 high
ENSG00000143379 SETDB1 ACC 7e-04 high
ENSG00000143379 SETDB1 READ 0.026 low
ENSG00000143379 SETDB1 KIRP 0.0055 high
ENSG00000143379 SETDB1 KICH 0.0011 high
ENSG00000143379 SETDB1 COAD 0.025 high
ENSG00000143379 SETDB1 UCS 0.048 low
ENSG00000143379 SETDB1 PRAD 0.042 low
ENSG00000143379 SETDB1 TGCT 0.0055 high
ENSG00000143379 SETDB1 LAML 0.027 low
ENSG00000143379 SETDB1 GBM 0.019 low
ENSG00000143379 SETDB1 SKCM 0.033 high
ENSG00000143379 SETDB1 LIHC 0.0013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000143379 SETDB1 CHOL Amp 0.764067 0.433097 0.983467 0.611111
ENSG00000143379 SETDB1 LUSC Amp 5.295456 0.312002 0.585825 0.518962
ENSG00000143379 SETDB1 LUAD Amp 27.011648 0.469236 0.643203 0.730620
ENSG00000143379 SETDB1 CESC Amp 3.774570 0.233252 0.632976 0.532203
ENSG00000143379 SETDB1 READ Amp 1.357261 0.159213 0.625018 0.284848
ENSG00000143379 SETDB1 UCS Amp 1.179902 0.574656 0.728525 0.714286
ENSG00000143379 SETDB1 SARC Amp 4.977530 0.453686 0.733518 0.396887
ENSG00000143379 SETDB1 ESCA Amp 0.644413 0.254896 0.492125 0.483696
ENSG00000143379 SETDB1 SKCM Amp 4.380858 0.227014 0.692221 0.544959
ENSG00000143379 SETDB1 LIHC Amp 20.835846 0.447675 0.912006 0.729730
ENSG00000143379 SETDB1 PCPG Amp 3.268801 0.113313 0.692676 0.172840
ENSG00000143379 SETDB1 TGCT Amp 0.946300 0.129739 0.452045 0.460000
ENSG00000143379 SETDB1 DLBC Amp 1.729887 0.282727 0.753609 0.208333
ENSG00000143379 SETDB1 BLCA Amp 24.096414 0.616909 0.748066 0.492647
ENSG00000143379 SETDB1 BRCA Amp 36.494962 0.464594 0.843899 0.721296
ENSG00000143379 SETDB1 STAD Amp 5.105624 0.239733 0.524156 0.362812
ENSG00000143379 SETDB1 PRAD Amp 2.645596 0.072184 0.603920 0.079268
ENSG00000143379 SETDB1 UCEC Amp 19.554966 0.347490 0.951814 0.450835
ENSG00000143379 SETDB1 OV Amp 25.060906 0.761534 0.832786 0.632124