Ensembl ID ENSG00000143368 Gene ID 10262 Accession 10771
Gene Symbol SF3B4 Alias AFD1;Hsh49;SAP49;SF3b49 Full Name splicing factor 3b subunit 4
Position 1 : 149923317 - 149927803 Length 4487 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008]

ENSG00000143368 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000143368 SF3B4 0.99 9.29e-68 BRCA
ENSG00000143368 SF3B4 0.83 1.21e-30 LUSC
ENSG00000143368 SF3B4 1.04 3.62e-31 LIHC
ENSG00000143368 SF3B4 0.64 3.57e-11 UCEC
ENSG00000143368 SF3B4 1.31 9.98e-12 CHOL
ENSG00000143368 SF3B4 0.71 4.90e-19 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000143368 SF3B4 tumor 17498563
ENSG00000143368 SF3B4 cancer 28042453
ENSG00000143368 SF3B4 cancer 28351319
ENSG00000143368 SF3B4 tumor 29059470
ENSG00000143368 SF3B4 tumor 30391496
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000143368 SF3B4 MESO 0.00064 high
ENSG00000143368 SF3B4 UCEC 0.015 high
ENSG00000143368 SF3B4 THCA 0.031 high
ENSG00000143368 SF3B4 LGG 0.00036 high
ENSG00000143368 SF3B4 LUSC 0.034 low
ENSG00000143368 SF3B4 HNSC 0.023 high
ENSG00000143368 SF3B4 LUAD 0.0073 high
ENSG00000143368 SF3B4 COAD 0.032 high
ENSG00000143368 SF3B4 DLBC 0.05 low
ENSG00000143368 SF3B4 LAML 0.028 high
ENSG00000143368 SF3B4 SKCM 0.00027 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000143368 SF3B4 CHOL Amp 0.764067 0.433097 0.983467 0.611111
ENSG00000143368 SF3B4 LUSC Amp 4.138471 0.287882 0.572801 0.497006
ENSG00000143368 SF3B4 LUAD Amp 21.901923 0.416371 0.620058 0.717054
ENSG00000143368 SF3B4 CESC Amp 1.847321 0.173546 0.606422 0.498305
ENSG00000143368 SF3B4 READ Amp 1.177106 0.149634 0.620331 0.266667
ENSG00000143368 SF3B4 UCS Amp 0.715068 0.495837 0.717296 0.660714
ENSG00000143368 SF3B4 SARC Amp 5.537493 0.473899 0.753610 0.389105
ENSG00000143368 SF3B4 SKCM Amp 3.296277 0.197880 0.667491 0.514986
ENSG00000143368 SF3B4 PCPG Amp 3.268801 0.113313 0.714144 0.166667
ENSG00000143368 SF3B4 TGCT Amp 0.728618 0.118943 0.456896 0.433333
ENSG00000143368 SF3B4 DLBC Amp 1.729887 0.282727 0.753609 0.208333
ENSG00000143368 SF3B4 PRAD Amp 1.748114 0.060651 0.582471 0.075203
ENSG00000143368 SF3B4 UCEC Amp 13.430372 0.285015 0.917370 0.426716
ENSG00000143368 SF3B4 OV Amp 16.141678 0.642513 0.783606 0.604491