Ensembl ID ENSG00000143321 Gene ID 3068 Accession 4856
Gene Symbol HDGF Alias HMG1L2 Full Name heparin binding growth factor
Position 1 : 156742109 - 156752448 Length 10340 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]

ENSG00000143321 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000143321 0.48 2.06e-12 HNSC
ENSG00000143321 1.22 1.29e-89 BRCA
ENSG00000143321 0.50 9.65e-13 COAD
ENSG00000143321 -1.0 2.61e-12 KICH
ENSG00000143321 1.20 9.66e-57 LUSC
ENSG00000143321 1.25 7.19e-35 UCEC
ENSG00000143321 1.01 2.34e-33 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000143321 fibroid tumors 11035994
ENSG00000143321 esophageal cancer 11479204
ENSG00000143321 cancer 12397753
ENSG00000143321 cancer 12816346
ENSG00000143321 tumor 14508832
ENSG00000143321 tumors 14535987
ENSG00000143321 tumor 14583466
ENSG00000143321 tumor 14662017
ENSG00000143321 non-small-cell lung cancer 15310766
ENSG00000143321 cancers 15604097
ENSG00000143321 non-small-cell lung cancer 15870924
ENSG00000143321 tumor 16397032
ENSG00000143321 non-small cell lung cancer 16397209
ENSG00000143321 tumor 16411141
ENSG00000143321 pancreatic cancer 17062679
ENSG00000143321 tumor 17473954
ENSG00000143321 gastrointestinal stromal tumors 17487837
ENSG00000143321 non-small cell lung cancer 18478933
ENSG00000143321 cancer 18651222
ENSG00000143321 cancer 18823380
ENSG00000143321 tumor 19144156
ENSG00000143321 tumors 19279430
ENSG00000143321 cancer 19432814
ENSG00000143321 lung cancer 19435872
ENSG00000143321 cancer 19710540
ENSG00000143321 tumor 19924574
ENSG00000143321 squamous cell lung cancer 20043047
ENSG00000143321 lung cancer 20193688
ENSG00000143321 colorectal cancer 20674562
ENSG00000143321 liver cancer 20846397
ENSG00000143321 cancers 20848225
ENSG00000143321 non-small cell lung cancer 21122296
ENSG00000143321 stomach cancer 21302807
ENSG00000143321 non-small cell lung cancer 21426662
ENSG00000143321 breast cancer 21567096
ENSG00000143321 cancer 22006999
ENSG00000143321 tumors 22014102
ENSG00000143321 GBM 22037800
ENSG00000143321 tumor 22048167
ENSG00000143321 breast cancer 22247069
ENSG00000143321 oral cancer 22361040
ENSG00000143321 ovarian cancer 22442705
ENSG00000143321 cancers 22576797
ENSG00000143321 tumor 22613005
ENSG00000143321 breast cancer 22682760
ENSG00000143321 cancer 22819846
ENSG00000143321 tumours 23305559
ENSG00000143321 Tumor 23536873
ENSG00000143321 gallbladder cancer 23609195
ENSG00000143321 tumor 23673296
ENSG00000143321 cancer 23695169
ENSG00000143321 cancer 23771064
ENSG00000143321 cancers 23771798
ENSG00000143321 tumors 23793608
ENSG00000143321 tumour 23878072
ENSG00000143321 non-small cell lung cancer 23954293
ENSG00000143321 cancers 23999841
ENSG00000143321 tumour 24072730
ENSG00000143321 gastric cancer 24276755
ENSG00000143321 tumor 24692842
ENSG00000143321 non-small cell lung cancer 24770635
ENSG00000143321 ovarian cancer 24831101
ENSG00000143321 tumor 24891187
ENSG00000143321 gallbladder cancer 25071353
ENSG00000143321 cancer 25236340
ENSG00000143321 cancers 25262276
ENSG00000143321 cervical cancer 25421244
ENSG00000143321 breast cancer 25454514
ENSG00000143321 tumor 25527451
ENSG00000143321 tumor 25559688
ENSG00000143321 Liver cancer 25569374
ENSG00000143321 tumors 25625699
ENSG00000143321 tumor 25677618
ENSG00000143321 tumors 25773828
ENSG00000143321 tumours 25938538
ENSG00000143321 cancer 26081074
ENSG00000143321 tumor 26101867
ENSG00000143321 non-small cells lung cancer 26175166
ENSG00000143321 colorectal cancer 26296979
ENSG00000143321 epithelial ovarian cancer 26316779
ENSG00000143321 cancers 26375396
ENSG00000143321 tumor 26392778
ENSG00000143321 ovarian cancer 26612514
ENSG00000143321 tumor 26637859
ENSG00000143321 colon cancers 26643252
ENSG00000143321 prostate cancer 26780929
ENSG00000143321 colorectal cancer 26885452
ENSG00000143321 tumor 27122967
ENSG00000143321 tumours 27273265
ENSG00000143321 prostate cancer 27692835
ENSG00000143321 cancer 27926477
ENSG00000143321 tumor 27942274
ENSG00000143321 Non-Small Cell Lung Cancer 28592712
ENSG00000143321 cervical cancer 28693232
ENSG00000143321 tumor 28713954
ENSG00000143321 Cancer 28751441
ENSG00000143321 tumor 28756624
ENSG00000143321 breast cancer 29108258
ENSG00000143321 tumor 29142712
ENSG00000143321 prostate cancer 29300772
ENSG00000143321 colorectal cancer 29321086
ENSG00000143321 cancers 29321480
ENSG00000143321 tumors 29344149
ENSG00000143321 tumor 29415727
ENSG00000143321 tumor 29564261
ENSG00000143321 tumor 29568375
ENSG00000143321 tumours 29614055
ENSG00000143321 tumor 29616111
ENSG00000143321 cancer 29805627
ENSG00000143321 cancer 30004626
ENSG00000143321 cancer 30083268
ENSG00000143321 tumor 30410367
ENSG00000143321 gastric cancer 30513684
ENSG00000143321 lung cancer 30585192
ENSG00000143321 cancer 30930987
ENSG00000143321 Endometrial Cancer 31032220
ENSG00000143321 pancreatic cancer 31078734
ENSG00000143321 cancer 31162607
ENSG00000143321 tumor 31257090
ENSG00000143321 cancer 31336658
ENSG00000143321 endometrial cancer 31363373
ENSG00000143321 tumor 31404556
ENSG00000143321 gastric cancer 31582403
ENSG00000143321 breast cancer 31586299
ENSG00000143321 tumor 31612005
ENSG00000143321 tumour 31632071
ENSG00000143321 tumor 31692549
ENSG00000143321 oral cancer 31711427
ENSG00000143321 gastric cancer 31726370
ENSG00000143321 endometrial cancer 31815037
ENSG00000143321 tumor 31942592
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000143321 MESO 0.0017 high
ENSG00000143321 SARC 0.011 high
ENSG00000143321 STAD 0.0028 low
ENSG00000143321 UVM 0.015 high
ENSG00000143321 PAAD 0.0017 high
ENSG00000143321 UCEC 0.00031 high
ENSG00000143321 LUSC 0.033 low
ENSG00000143321 KIRP 3e-04 high
ENSG00000143321 LUAD 0.00053 high
ENSG00000143321 THYM 0.031 low
ENSG00000143321 COAD 0.027 high
ENSG00000143321 ESCA 0.035 high
ENSG00000143321 OV 0.0013 low
ENSG00000143321 DLBC 0.00041 low
ENSG00000143321 KIRC 0.036 high
ENSG00000143321 BLCA 0.049 high
ENSG00000143321 LAML 0.009 high
ENSG00000143321 GBM 0.029 low
ENSG00000143321 SKCM 0.0029 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000143321 CHOL Amp 0.763398 0.432674 0.995527 0.611111
ENSG00000143321 LUSC Amp 2.115512 0.238832 0.530033 0.520958
ENSG00000143321 LUAD Amp 11.615229 0.296780 0.565868 0.720930
ENSG00000143321 LGG Amp 1.068291 0.049421 0.553095 0.079922
ENSG00000143321 CESC Amp 2.224565 0.186473 0.610429 0.542373
ENSG00000143321 UCS Amp 0.729539 0.496521 0.736562 0.678571
ENSG00000143321 SARC Amp 2.691448 0.360501 0.699754 0.357977
ENSG00000143321 SKCM Amp 2.008858 0.161853 0.679995 0.542234
ENSG00000143321 LIHC Amp 16.403934 0.375742 0.900426 0.748649
ENSG00000143321 PCPG Amp 1.505568 0.085472 0.655169 0.166667
ENSG00000143321 TGCT Amp 0.676527 0.115643 0.451044 0.453333
ENSG00000143321 DLBC Amp 1.852987 0.292853 0.670338 0.270833
ENSG00000143321 BLCA Amp 6.300963 0.317641 0.548195 0.443627
ENSG00000143321 BRCA Amp 16.049466 0.318081 0.781421 0.720370
ENSG00000143321 STAD Amp 1.042485 0.142050 0.438634 0.356009
ENSG00000143321 UCEC Amp 7.250454 0.213107 0.853615 0.448980
ENSG00000143321 OV Amp 5.034348 0.451455 0.682429 0.587219