Ensembl ID ENSG00000141499 Gene ID 55135 Accession 25522
Gene Symbol WRAP53 Alias DKCB3;TCAB1;WDR79 Full Name WD repeat containing antisense to TP53
Position 17 : 7686071 - 7703502 Length 17432 bases Strand Plus strand
Status Confidence Main interacting RNAsncRNARBP type Non-canonical_RBPs
Summary This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

ENSG00000141499 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000141499 WRAP53 0.45 1.33e-15 BRCA
ENSG00000141499 WRAP53 0.82 4.11e-14 KIRP
ENSG00000141499 WRAP53 0.85 1.93e-11 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000141499 WRAP53 susceptibility to breast cancer 17683073
ENSG00000141499 WRAP53 cancer 19179534
ENSG00000141499 WRAP53 tumor 21368886
ENSG00000141499 WRAP53 tumor 21924287
ENSG00000141499 WRAP53 metastatic tumor 22805008
ENSG00000141499 WRAP53 ovarian cancer 23192612
ENSG00000141499 WRAP53 breast tumor 23886136
ENSG00000141499 WRAP53 tumor 24626331
ENSG00000141499 WRAP53 head and neck cancers 25070141
ENSG00000141499 WRAP53 cancer 25120649
ENSG00000141499 WRAP53 breast cancer 25134915
ENSG00000141499 WRAP53 Tumor 25456005
ENSG00000141499 WRAP53 cancer 25852739
ENSG00000141499 WRAP53 tumor 25854392
ENSG00000141499 WRAP53 cancer 26286192
ENSG00000141499 WRAP53 epithelial ovarian cancer 26426684
ENSG00000141499 WRAP53 Breast Cancer 26460974
ENSG00000141499 WRAP53 cancer 26734725
ENSG00000141499 WRAP53 small cell lung cancer 26849396
ENSG00000141499 WRAP53 tumor 27310875
ENSG00000141499 WRAP53 cancer 27525856
ENSG00000141499 WRAP53 cancer 27715493
ENSG00000141499 WRAP53 tumor 28180319
ENSG00000141499 WRAP53 tumor 28347242
ENSG00000141499 WRAP53 non-small cell lung cancer 28406480
ENSG00000141499 WRAP53 cancer 28607398
ENSG00000141499 WRAP53 laryngeal cancer 28849066
ENSG00000141499 WRAP53 non-small cell lung cancer 29516630
ENSG00000141499 WRAP53 cancer 30405890
ENSG00000141499 WRAP53 tumor 31052265
ENSG00000141499 WRAP53 non-small cell lung cancer 31281482
ENSG00000141499 WRAP53 cancer 31334247
ENSG00000141499 WRAP53 breast cancer 31387111
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000141499 WRAP53 MESO 0.00035 high
ENSG00000141499 WRAP53 SARC 0.00048 high
ENSG00000141499 WRAP53 CHOL 0.0046 high
ENSG00000141499 WRAP53 PAAD 0.00018 low
ENSG00000141499 WRAP53 UCEC 0.0024 low
ENSG00000141499 WRAP53 THCA 0.028 high
ENSG00000141499 WRAP53 LGG 0.00013 high
ENSG00000141499 WRAP53 HNSC 0.034 low
ENSG00000141499 WRAP53 READ 0.00094 low
ENSG00000141499 WRAP53 KIRP 0.00088 low
ENSG00000141499 WRAP53 KICH 0.0032 high
ENSG00000141499 WRAP53 LUAD 0.021 high
ENSG00000141499 WRAP53 PCPG 0.0036 low
ENSG00000141499 WRAP53 THYM 0.024 low
ENSG00000141499 WRAP53 BRCA 0.017 low
ENSG00000141499 WRAP53 UCS 0.017 high
ENSG00000141499 WRAP53 BLCA 0.0019 low
ENSG00000141499 WRAP53 SKCM 0.00014 high
ENSG00000141499 WRAP53 CESC 0.00089 low
ENSG00000141499 WRAP53 LIHC 0.00038 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000141499 WRAP53 SARC Del 51.686127 0.706461 0.730365 0.494163
ENSG00000141499 WRAP53 GBM Del 7.018970 0.106576 0.525978 0.168111
ENSG00000141499 WRAP53 PAAD Del 0.661177 0.044130 0.389425 0.489130
ENSG00000141499 WRAP53 LIHC Del 9.402392 0.161227 0.662110 0.608108
ENSG00000141499 WRAP53 PCPG Del 0.992968 0.064825 0.647723 0.401235
ENSG00000141499 WRAP53 BRCA Del 4.178757 0.088216 0.491343 0.609259
ENSG00000141499 WRAP53 PRAD Del 33.802923 0.266261 0.559196 0.329268