Ensembl ID ENSG00000141431 Gene ID 80816 Accession 29357
Gene Symbol ASXL3 Alias BRPS;KIAA1713 Full Name ASXL transcriptional regulator 3
Position 18 : 33578219 - 33751195 Length 172977 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a protein containing a plant homeodomain (PHD) zinc finger domain that plays a role in the regulation of gene transcription. The encoded protein has been shown to negatively regulate lipogenesis by binding to and inhibiting the transcriptional activity of two nuclear hormone receptors, oxysterols receptor LXR-alpha (LXRalpha) and thyroid hormone receptor beta (TRbeta). The encoded protein may also inhibit histone deubiquitination. Mutations in this gene have been identified in human patients with Bainbridge-Ropers syndrome, which is characterized by feeding difficulties, developmental delay and other features. [provided by RefSeq, May 2017]

ENSG00000141431 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000141431 -1.4 1.71e-16 BRCA
ENSG00000141431 -2.0 3.57e-13 COAD
ENSG00000141431 -1.2 6.41e-13 PRAD
ENSG00000141431 -3.3 6.04e-11 ESCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000141431 head and neck tumor 15138607
ENSG00000141431 cancer 15375572
ENSG00000141431 breast cancer 23736028
ENSG00000141431 tumor 25393105
ENSG00000141431 tumor 26192917
ENSG00000141431 cancer 27527698
ENSG00000141431 cancer 27864402
ENSG00000141431 lung cancer 28194004
ENSG00000141431 Small Cell Lung Cancer 28935813
ENSG00000141431 parathyroid tumors 29982334
ENSG00000141431 tumor 30349006
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000141431 SARC 0.035 high
ENSG00000141431 CHOL 0.003 high
ENSG00000141431 PAAD 0.0075 low
ENSG00000141431 UCEC 0.00056 high
ENSG00000141431 THCA 0.0058 high
ENSG00000141431 ACC 0.013 low
ENSG00000141431 LUSC 0.018 high
ENSG00000141431 KIRP 0.0021 low
ENSG00000141431 KICH 0.012 high
ENSG00000141431 LUAD 0.0072 low
ENSG00000141431 BRCA 0.015 low
ENSG00000141431 BLCA 0.013 high
ENSG00000141431 LAML 0.011 high
ENSG00000141431 GBM 0.0055 low
ENSG00000141431 LIHC 0.025 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000141431 STAD Del 0.649459 0.059656 0.403039 0.365079