Ensembl ID ENSG00000140105 Gene ID 7453 Accession 12729
Gene Symbol WARS1 Alias HMN9;WARS;IFI53;IFP53;GAMMA-2;NEDMSBA Full Name tryptophanyl-tRNA synthetase 1
Position 14 : 100333790 - 100376805 Length 43016 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000140105 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000140105 WARS1 1.79 2.74e-14 HNSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000140105 WARS1 cancer 14647428
ENSG00000140105 WARS1 cancer 16798061
ENSG00000140105 WARS1 tumor 23957735
ENSG00000140105 WARS1 tumor 25767870
ENSG00000140105 WARS1 tumors 26376692
ENSG00000140105 WARS1 oral cancer 29391733
ENSG00000140105 WARS1 breast cancer 30524887
ENSG00000140105 WARS1 cancer 30613102
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000140105 WARS1 MESO 0.048 low
ENSG00000140105 WARS1 PAAD 0.0054 high
ENSG00000140105 WARS1 ACC 0.032 high
ENSG00000140105 WARS1 READ 0.04 low
ENSG00000140105 WARS1 KICH 0.02 high
ENSG00000140105 WARS1 THYM 0.0067 low
ENSG00000140105 WARS1 BRCA 0.023 low
ENSG00000140105 WARS1 OV 0.00029 low
ENSG00000140105 WARS1 DLBC 0.043 low
ENSG00000140105 WARS1 KIRC 0.023 low
ENSG00000140105 WARS1 BLCA 0.0077 low
ENSG00000140105 WARS1 LAML 0.0037 high
ENSG00000140105 WARS1 CESC 0.016 low
ENSG00000140105 WARS1 LIHC 0.00092 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000140105 WARS1 CHOL Del 2.006740 0.312766 0.658372 0.555556
ENSG00000140105 WARS1 LUAD Del 1.399763 0.060637 0.313032 0.279070
ENSG00000140105 WARS1 LGG Del 5.571627 0.078719 0.532805 0.210526
ENSG00000140105 WARS1 CESC Del 2.390336 0.097255 0.477783 0.169492
ENSG00000140105 WARS1 GBM Del 1.310539 0.059855 0.580819 0.280763
ENSG00000140105 WARS1 LIHC Del 3.730253 0.107387 0.511181 0.359459
ENSG00000140105 WARS1 DLBC Amp 0.769567 0.191566 2.134740 0.041667
ENSG00000140105 WARS1 BRCA Del 2.091890 0.075284 0.402706 0.288889
ENSG00000140105 WARS1 STAD Del 0.963040 0.064566 0.340031 0.292517