Ensembl ID ENSG00000139793 Gene ID 10150 Accession 16746
Gene Symbol MBNL2 Alias MBLL;MBLL39;PRO2032 Full Name muscleblind like splicing regulator 2
Position 13 : 97221434 - 97394120 Length 172687 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. [provided by RefSeq, Mar 2012]

ENSG00000139793 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000139793 MBNL2 -1.0 1.38e-40 BRCA
ENSG00000139793 MBNL2 -1.0 1.38e-15 KICH
ENSG00000139793 MBNL2 -1.1 1.82e-23 LUSC
ENSG00000139793 MBNL2 -1.1 1.65e-24 PRAD
ENSG00000139793 MBNL2 -2.1 2.38e-17 GBM
ENSG00000139793 MBNL2 -1.3 4.70e-25 LIHC
ENSG00000139793 MBNL2 -1.6 8.71e-34 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000139793 MBNL2 tumors 17054779
ENSG00000139793 MBNL2 tumor 27564110
ENSG00000139793 MBNL2 prostate cancer 29643985
ENSG00000139793 MBNL2 tumor 31320607
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000139793 MBNL2 MESO 0.047 high
ENSG00000139793 MBNL2 SARC 0.00027 low
ENSG00000139793 MBNL2 STAD 0.014 high
ENSG00000139793 MBNL2 UVM 0.013 low
ENSG00000139793 MBNL2 PAAD 0.00035 high
ENSG00000139793 MBNL2 UCEC 0.038 high
ENSG00000139793 MBNL2 ACC 0.015 low
ENSG00000139793 MBNL2 LGG 0.0071 high
ENSG00000139793 MBNL2 THYM 0.017 low
ENSG00000139793 MBNL2 COAD 0.033 low
ENSG00000139793 MBNL2 LAML 0.039 low
ENSG00000139793 MBNL2 SKCM 0.0052 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000139793 MBNL2 CESC Amp 1.796306 0.171997 0.543274 0.203390
ENSG00000139793 MBNL2 READ Amp 1.113249 0.146575 1.017866 0.703030
ENSG00000139793 MBNL2 COAD Amp 3.995845 0.124749 0.904458 0.580931
ENSG00000139793 MBNL2 SARC Del 1.370864 0.141124 0.584656 0.455253
ENSG00000139793 MBNL2 THCA Del 0.708100 0.008462 0.568368 0.030060
ENSG00000139793 MBNL2 LIHC Amp 7.215183 0.245498 0.816377 0.167568
ENSG00000139793 MBNL2 BRCA Amp 0.865888 0.148807 0.620255 0.148148
ENSG00000139793 MBNL2 STAD Amp 0.822027 0.134711 0.547613 0.367347