Ensembl ID ENSG00000139726 Gene ID 8562 Accession 2769
Gene Symbol DENR Alias DRP;DRP1;SMAP-3 Full Name density regulated re-initiation and release factor
Position 12 : 122752824 - 122771064 Length 18241 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

ENSG00000139726 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000139726 DENR 0.42 2.47e-22 BRCA
ENSG00000139726 DENR 0.50 1.52e-11 COAD
ENSG00000139726 DENR 1.07 3.64e-73 LUSC
ENSG00000139726 DENR 0.66 1.59e-25 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000139726 DENR cancer 15492250
ENSG00000139726 DENR breast cancer 17430158
ENSG00000139726 DENR cancer 18824261
ENSG00000139726 DENR Brain Tumor 25250163
ENSG00000139726 DENR cancer 26088749
ENSG00000139726 DENR cancer 26636041
ENSG00000139726 DENR tumors 27061526
ENSG00000139726 DENR brain tumors 27171399
ENSG00000139726 DENR breast cancer 27566580
ENSG00000139726 DENR tumor 28280386
ENSG00000139726 DENR cancer 28623304
ENSG00000139726 DENR cancer 28723557
ENSG00000139726 DENR metastatic tumor 28938688
ENSG00000139726 DENR cancer 29137307
ENSG00000139726 DENR cancer 29273096
ENSG00000139726 DENR tumor 29566065
ENSG00000139726 DENR cancer 29572068
ENSG00000139726 DENR cancer 29797762
ENSG00000139726 DENR tumor 30099635
ENSG00000139726 DENR tumor 30415246
ENSG00000139726 DENR gastric cancer 30655749
ENSG00000139726 DENR breast cancer 30668548
ENSG00000139726 DENR cancer 30982898
ENSG00000139726 DENR tumor 31617997
ENSG00000139726 DENR lung cancer 31889802
ENSG00000139726 DENR cancer 9014227
ENSG00000139726 DENR tumor 9209662
ENSG00000139726 DENR tumors 9583721
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000139726 DENR MESO 0.00053 high
ENSG00000139726 DENR UVM 0.045 high
ENSG00000139726 DENR UCEC 0.0059 high
ENSG00000139726 DENR ACC 0.00016 high
ENSG00000139726 DENR LUSC 0.035 low
ENSG00000139726 DENR HNSC 0.0031 high
ENSG00000139726 DENR LUAD 0.0044 high
ENSG00000139726 DENR PCPG 0.0029 high
ENSG00000139726 DENR THYM 0.0055 low
ENSG00000139726 DENR BRCA 0.008 high
ENSG00000139726 DENR UCS 0.0022 low
ENSG00000139726 DENR OV 0.0054 low
ENSG00000139726 DENR GBM 0.037 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000139726 DENR LUAD Del 0.796229 0.052664 0.278882 0.240310
ENSG00000139726 DENR UCS Del 0.949825 0.222330 0.576026 0.321429
ENSG00000139726 DENR PAAD Del 1.190600 0.055898 0.347525 0.217391
ENSG00000139726 DENR LIHC Del 2.338206 0.090416 0.433176 0.151351
ENSG00000139726 DENR BRCA Del 3.746140 0.085810 0.373803 0.196296
ENSG00000139726 DENR UCEC Del 3.040533 0.072913 0.422129 0.118738
ENSG00000139726 DENR OV Del 5.405021 0.251496 0.574009 0.329879