Ensembl ID ENSG00000138646 Gene ID 51191 Accession 24368
Gene Symbol HERC5 Alias CEB1;CEBP1 Full Name HECT and RLD domain containing E3 ubiquitin protein ligase 5
Position 4 : 88457119 - 88506163 Length 49045 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021]

ENSG00000138646 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000138646 1.93 1.98e-23 HNSC
ENSG00000138646 -1.4 5.05e-12 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000138646 cancer 21087171
ENSG00000138646 lung cancer 25353388
ENSG00000138646 tumor 26653219
ENSG00000138646 GBM 28035070
ENSG00000138646 cancer 28919514
ENSG00000138646 cancers 29027969
ENSG00000138646 AMLs 30954792
ENSG00000138646 breast cancer 31225658
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000138646 MESO 0.00088 low
ENSG00000138646 SARC 0.016 low
ENSG00000138646 STAD 0.014 high
ENSG00000138646 CHOL 0.038 low
ENSG00000138646 UVM 0.0039 low
ENSG00000138646 THCA 0.0028 low
ENSG00000138646 ACC 0.046 low
ENSG00000138646 LUSC 0.0096 high
ENSG00000138646 KIRP 0.00032 low
ENSG00000138646 LUAD 0.045 low
ENSG00000138646 PCPG 0.0019 high
ENSG00000138646 THYM 0.026 low
ENSG00000138646 ESCA 0.038 low
ENSG00000138646 DLBC 0.025 high
ENSG00000138646 KIRC 0.00012 low
ENSG00000138646 PRAD 0.042 low
ENSG00000138646 TGCT 0.028 low
ENSG00000138646 SKCM 0.027 low
ENSG00000138646 CESC 0.0015 low
ENSG00000138646 LIHC 0.038 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000138646 LIHC Del 4.601958 0.117336 0.560670 0.451351
ENSG00000138646 STAD Del 0.697267 0.060393 0.331478 0.405896
ENSG00000138646 OV Del 2.918997 0.218026 0.621291 0.661485