Ensembl ID
ENSG00000138035
Gene ID
87178
Accession
23166
Gene Symbol
PNPT1
Alias
OLD35;SCA25;DFNB70;PNPASE;old-35;COXPD13
Full Name
polyribonucleotide nucleotidyltransferase 1
Position
2 : 55634061 - 55693863
Length
59803 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs diverse RBP type
Canonical_RBPs
Summary
The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]
ENSG00000138035 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000138035
PNPT1
0.43
1.76e-14
BRCA
ENSG00000138035
PNPT1
1.03
1.99e-36
COAD
ENSG00000138035
PNPT1
1.08
2.00e-36
LUSC
ENSG00000138035
PNPT1
1.00
2.88e-23
STAD
ENSG00000138035
PNPT1
0.72
5.54e-19
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000138035
PNPT1
tumor
19580345
ENSG00000138035
PNPT1
tumor
22370639
ENSG00000138035
PNPT1
oral cancer
31940341
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000138035
PNPT1
MESO
0.0039
high
show
ENSG00000138035
PNPT1
UCEC
0.00043
high
show
ENSG00000138035
PNPT1
LUSC
0.029
low
show
ENSG00000138035
PNPT1
HNSC
0.012
high
show
ENSG00000138035
PNPT1
KICH
0.0028
high
show
ENSG00000138035
PNPT1
LUAD
0.037
high
show
ENSG00000138035
PNPT1
BRCA
0.043
high
show
ENSG00000138035
PNPT1
ESCA
0.012
high
show
ENSG00000138035
PNPT1
OV
0.044
low
show
ENSG00000138035
PNPT1
KIRC
0.048
high
show
ENSG00000138035
PNPT1
PRAD
0.015
low
show
ENSG00000138035
PNPT1
GBM
0.03
low
show
ENSG00000138035
PNPT1
SKCM
0.014
low
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000138035
PNPT1
LUSC
Amp
3.550030
0.274953
0.569798
0.534930
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