Ensembl ID ENSG00000138035 Gene ID 87178 Accession 23166
Gene Symbol PNPT1 Alias OLD35;SCA25;DFNB70;PNPASE;old-35;COXPD13 Full Name polyribonucleotide nucleotidyltransferase 1
Position 2 : 55634061 - 55693863 Length 59803 bases Strand Minus strand
Status Confidence Main interacting RNAsdiverseRBP type Canonical_RBPs
Summary The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]

ENSG00000138035 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000138035 PNPT1 0.43 1.76e-14 BRCA
ENSG00000138035 PNPT1 1.03 1.99e-36 COAD
ENSG00000138035 PNPT1 1.08 2.00e-36 LUSC
ENSG00000138035 PNPT1 1.00 2.88e-23 STAD
ENSG00000138035 PNPT1 0.72 5.54e-19 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000138035 PNPT1 tumor 19580345
ENSG00000138035 PNPT1 tumor 22370639
ENSG00000138035 PNPT1 oral cancer 31940341
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000138035 PNPT1 MESO 0.0039 high
ENSG00000138035 PNPT1 UCEC 0.00043 high
ENSG00000138035 PNPT1 LUSC 0.029 low
ENSG00000138035 PNPT1 HNSC 0.012 high
ENSG00000138035 PNPT1 KICH 0.0028 high
ENSG00000138035 PNPT1 LUAD 0.037 high
ENSG00000138035 PNPT1 BRCA 0.043 high
ENSG00000138035 PNPT1 ESCA 0.012 high
ENSG00000138035 PNPT1 OV 0.044 low
ENSG00000138035 PNPT1 KIRC 0.048 high
ENSG00000138035 PNPT1 PRAD 0.015 low
ENSG00000138035 PNPT1 GBM 0.03 low
ENSG00000138035 PNPT1 SKCM 0.014 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000138035 PNPT1 LUSC Amp 3.550030 0.274953 0.569798 0.534930