Ensembl ID ENSG00000138029 Gene ID 3032 Accession 4803
Gene Symbol HADHB Alias ECHB;MTPB;MTPD;MTPD2;MSTP029;TP-BETA Full Name hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Position 2 : 26243170 - 26290465 Length 47296 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

ENSG00000138029 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000138029 HADHB -0.7 1.36e-28 KIRC
ENSG00000138029 HADHB -1.0 8.31e-46 HNSC
ENSG00000138029 HADHB -0.4 3.11e-24 BRCA
ENSG00000138029 HADHB -1.0 9.48e-56 COAD
ENSG00000138029 HADHB -0.9 1.70e-12 READ
ENSG00000138029 HADHB -2.0 7.93e-13 PCPG
ENSG00000138029 HADHB -0.6 4.95e-13 LIHC
ENSG00000138029 HADHB -1.0 1.91e-34 STAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000138029 HADHB bladder cancer 18519668
ENSG00000138029 HADHB prostate cancer 21357687
ENSG00000138029 HADHB breast cancer 22375075
ENSG00000138029 HADHB breast cancer 23000159
ENSG00000138029 HADHB bladder cancer 23388178
ENSG00000138029 HADHB tumor 24115277
ENSG00000138029 HADHB bladder cancer 25202904
ENSG00000138029 HADHB tumour 26296974
ENSG00000138029 HADHB renal cancer 26942765
ENSG00000138029 HADHB prostate cancer 27689401
ENSG00000138029 HADHB prostate cancer 28108419
ENSG00000138029 HADHB prostate cancer 28890397
ENSG00000138029 HADHB bladder cancer 29147649
ENSG00000138029 HADHB tumor 29507648
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000138029 HADHB MESO 0.013 low
ENSG00000138029 HADHB STAD 0.025 high
ENSG00000138029 HADHB UVM 0.024 high
ENSG00000138029 HADHB ACC 0.048 high
ENSG00000138029 HADHB HNSC 0.022 high
ENSG00000138029 HADHB READ 0.033 low
ENSG00000138029 HADHB KIRP 0.0016 low
ENSG00000138029 HADHB PCPG 0.01 high
ENSG00000138029 HADHB THYM 0.0096 high
ENSG00000138029 HADHB BRCA 0.015 high
ENSG00000138029 HADHB DLBC 0.039 high
ENSG00000138029 HADHB LAML 0.0032 low
ENSG00000138029 HADHB SKCM 0.0041 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000138029 HADHB TGCT Amp 1.969747 0.177402 0.450564 0.406667