Ensembl ID ENSG00000137834 Gene ID 4091 Accession 6772
Gene Symbol SMAD6 Alias AOVD2;MADH6;MADH7;HsT17432 Full Name SMAD family member 6
Position 15 : 66702236 - 66782849 Length 80614 bases Strand Plus strand
Status Confidence Main interacting RNAsncRNARBP type Non-canonical_RBPs
Summary The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]

ENSG00000137834 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000137834 SMAD6 0.86 5.14e-12 COAD
ENSG00000137834 SMAD6 -2.7 6.42e-76 LUSC
ENSG00000137834 SMAD6 -0.8 4.83e-13 PRAD
ENSG00000137834 SMAD6 -0.9 3.46e-11 LIHC
ENSG00000137834 SMAD6 -2.5 1.83e-90 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000137834 SMAD6 pancreatic cancer 10049697
ENSG00000137834 SMAD6 tumor 10942134
ENSG00000137834 SMAD6 ovarian cancers 11078792
ENSG00000137834 SMAD6 Pancreatic cancers 11135319
ENSG00000137834 SMAD6 colorectal cancer 12866583
ENSG00000137834 SMAD6 tumor 14633701
ENSG00000137834 SMAD6 tumors 16333029
ENSG00000137834 SMAD6 lung cancer 19047146
ENSG00000137834 SMAD6 malignant tumors 20375427
ENSG00000137834 SMAD6 tumor 20462450
ENSG00000137834 SMAD6 invasive breast cancer 21527583
ENSG00000137834 SMAD6 tumor 21768661
ENSG00000137834 SMAD6 ovarian cancer 21984931
ENSG00000137834 SMAD6 tumor 22195733
ENSG00000137834 SMAD6 tumor 22223368
ENSG00000137834 SMAD6 ovarian cancer 22685544
ENSG00000137834 SMAD6 breast tumors 25077702
ENSG00000137834 SMAD6 tumor 26300991
ENSG00000137834 SMAD6 lung cancer 26543496
ENSG00000137834 SMAD6 lung cancer 26683690
ENSG00000137834 SMAD6 colon cancer 26852921
ENSG00000137834 SMAD6 breast cancer 27113436
ENSG00000137834 SMAD6 tumor 27662660
ENSG00000137834 SMAD6 rhabdoid tumor 28108836
ENSG00000137834 SMAD6 cancers 28500316
ENSG00000137834 SMAD6 lung cancer 28601662
ENSG00000137834 SMAD6 tumour 29352111
ENSG00000137834 SMAD6 tumor 29749927
ENSG00000137834 SMAD6 tumor 29950561
ENSG00000137834 SMAD6 AML 30177817
ENSG00000137834 SMAD6 tumor 30468556
ENSG00000137834 SMAD6 breast cancer 31694641
ENSG00000137834 SMAD6 tumor 9436979
ENSG00000137834 SMAD6 lung cancer 9712726
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000137834 SMAD6 MESO 0.0093 high
ENSG00000137834 SMAD6 SARC 0.023 high
ENSG00000137834 SMAD6 STAD 0.0035 low
ENSG00000137834 SMAD6 UVM 0.019 high
ENSG00000137834 SMAD6 PAAD 0.0013 high
ENSG00000137834 SMAD6 THCA 0.033 low
ENSG00000137834 SMAD6 LGG 0.0084 high
ENSG00000137834 SMAD6 LUSC 0.034 high
ENSG00000137834 SMAD6 HNSC 0.0046 low
ENSG00000137834 SMAD6 KICH 0.03 low
ENSG00000137834 SMAD6 THYM 0.036 low
ENSG00000137834 SMAD6 BRCA 0.033 low
ENSG00000137834 SMAD6 COAD 0.025 high
ENSG00000137834 SMAD6 UCS 0.035 low
ENSG00000137834 SMAD6 TGCT 0.039 high
ENSG00000137834 SMAD6 CESC 0.011 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000137834 SMAD6 UCS Del 0.968684 0.224263 0.476964 0.642857