Ensembl ID ENSG00000137818 Gene ID 6176 Accession 10372
Gene Symbol RPLP1 Alias P1;LP1;RPP1 Full Name ribosomal protein lateral stalk subunit P1
Position 15 : 69452814 - 69456205 Length 3392 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

ENSG00000137818 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000137818 RPLP1 0.70 4.15e-15 KIRC
ENSG00000137818 RPLP1 0.72 1.26e-13 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000137818 RPLP1 tumor 22399737
ENSG00000137818 RPLP1 melanotic neuroectodermal tumor of infancy 27519597
ENSG00000137818 RPLP1 tumor 30386179
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000137818 RPLP1 SARC 0.03 low
ENSG00000137818 RPLP1 STAD 0.027 high
ENSG00000137818 RPLP1 UVM 0.0032 low
ENSG00000137818 RPLP1 UCEC 0.048 low
ENSG00000137818 RPLP1 THCA 0.011 low
ENSG00000137818 RPLP1 LGG 0.002 low
ENSG00000137818 RPLP1 LUSC 0.042 low
ENSG00000137818 RPLP1 KIRP 0.00066 high
ENSG00000137818 RPLP1 BRCA 0.0069 low
ENSG00000137818 RPLP1 COAD 0.023 high
ENSG00000137818 RPLP1 DLBC 0.048 high
ENSG00000137818 RPLP1 LAML 0.0084 high
ENSG00000137818 RPLP1 GBM 0.035 high
ENSG00000137818 RPLP1 SKCM 0.02 high
ENSG00000137818 RPLP1 CESC 0.032 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000137818 RPLP1 UCS Del 0.663607 0.199130 0.471608 0.607143