Ensembl ID ENSG00000137760 Gene ID 91801 Accession 25189
Gene Symbol ALKBH8 Alias ABH8;TRM9;MRT71;TRMT9;TRMT9A Full Name alkB homolog 8, tRNA methyltransferase
Position 11 : 107502727 - 107565742 Length 63016 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary Enables tRNA (uracil) methyltransferase activity; tRNA binding activity; and zinc ion binding activity. Involved in cellular response to DNA damage stimulus; tRNA methylation; and tRNA wobble uridine modification. Located in cytosol and nuclear body. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000137760 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000137760 ALKBH8 -0.9 2.53e-21 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000137760 ALKBH8 bladder cancer 19293182
ENSG00000137760 ALKBH8 cancer 26438534
ENSG00000137760 ALKBH8 bladder cancer 27329810
ENSG00000137760 ALKBH8 cancer 28134793
ENSG00000137760 ALKBH8 cancer 30010922
ENSG00000137760 ALKBH8 cancer 30597914
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000137760 ALKBH8 MESO 0.04 low
ENSG00000137760 ALKBH8 SARC 0.042 high
ENSG00000137760 ALKBH8 CHOL 0.021 low
ENSG00000137760 ALKBH8 PAAD 0.00076 high
ENSG00000137760 ALKBH8 THCA 0.0019 high
ENSG00000137760 ALKBH8 ACC 0.021 high
ENSG00000137760 ALKBH8 LGG 0.032 high
ENSG00000137760 ALKBH8 READ 0.0013 low
ENSG00000137760 ALKBH8 KICH 0.0018 high
ENSG00000137760 ALKBH8 THYM 0.019 low
ENSG00000137760 ALKBH8 BRCA 0.0066 high
ENSG00000137760 ALKBH8 ESCA 0.026 low
ENSG00000137760 ALKBH8 KIRC 0.0017 low
ENSG00000137760 ALKBH8 PRAD 0.037 high
ENSG00000137760 ALKBH8 GBM 0.013 low
ENSG00000137760 ALKBH8 SKCM 0.0059 low
ENSG00000137760 ALKBH8 LIHC 0.034 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000137760 ALKBH8 LUSC Del 1.357415 0.075202 0.341017 0.331337
ENSG00000137760 ALKBH8 LUAD Del 3.259894 0.079310 0.336055 0.220930
ENSG00000137760 ALKBH8 CESC Del 19.945687 0.253230 0.557577 0.518644
ENSG00000137760 ALKBH8 KIRP Del 4.343645 0.060147 0.575535 0.107639
ENSG00000137760 ALKBH8 SARC Del 3.770818 0.194624 0.545883 0.420233
ENSG00000137760 ALKBH8 ESCA Del 2.077530 0.135331 0.447715 0.413043
ENSG00000137760 ALKBH8 SKCM Del 21.187825 0.246620 0.547434 0.544959
ENSG00000137760 ALKBH8 HNSC Del 13.590051 0.140413 0.439111 0.450192
ENSG00000137760 ALKBH8 LIHC Del 1.367692 0.076663 0.477968 0.243243
ENSG00000137760 ALKBH8 TGCT Del 1.689811 0.080838 0.465351 0.793333
ENSG00000137760 ALKBH8 BLCA Del 2.112188 0.100039 0.404507 0.362745
ENSG00000137760 ALKBH8 BRCA Del 46.827960 0.218836 0.527608 0.482407
ENSG00000137760 ALKBH8 STAD Del 1.404773 0.070704 0.352455 0.204082
ENSG00000137760 ALKBH8 UCEC Del 1.973809 0.063071 0.522604 0.163265