Ensembl ID ENSG00000137462 Gene ID 7097 Accession 11848
Gene Symbol TLR2 Alias TIL4;CD282 Full Name toll like receptor 2
Position 4 : 153684070 - 153706260 Length 22191 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

ENSG00000137462 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000137462 1.58 4.56e-46 KIRC
ENSG00000137462 -1.3 2.13e-27 LUSC
ENSG00000137462 -1.4 7.75e-26 PRAD
ENSG00000137462 1.31 1.36e-13 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000137462 colon cancer 11725828
ENSG00000137462 tumour 11890657
ENSG00000137462 tumour 12153529
ENSG00000137462 tumour 12709026
ENSG00000137462 cancer 12853386
ENSG00000137462 cancer 14666723
ENSG00000137462 tumour 14960149
ENSG00000137462 tumour 15270740
ENSG00000137462 tumour 15910421
ENSG00000137462 tumour 15958075
ENSG00000137462 pediatric AML 16107886
ENSG00000137462 tumor 16230348
ENSG00000137462 tumour 16277694
ENSG00000137462 prostate cancer 16302262
ENSG00000137462 cancer 16339564
ENSG00000137462 tumour 16443736
ENSG00000137462 tumour 16507115
ENSG00000137462 tumour 16826536
ENSG00000137462 colorectal cancer 16879199
ENSG00000137462 cancer 16925606
ENSG00000137462 tumor 16947020
ENSG00000137462 tumor 17218388
ENSG00000137462 tumour 17374884
ENSG00000137462 Cancer 17383632
ENSG00000137462 tumour 17454932
ENSG00000137462 tumor 17483348
ENSG00000137462 tumour 17567674
ENSG00000137462 tumour 17667928
ENSG00000137462 tumour 17686802
ENSG00000137462 tumor 17698636
ENSG00000137462 gastric cancer 17711514
ENSG00000137462 tumour 17714490
ENSG00000137462 tumor 17767155
ENSG00000137462 cancer 18317361
ENSG00000137462 tumors 18452561
ENSG00000137462 tumor 18490716
ENSG00000137462 tumor 18664270
ENSG00000137462 tumors 18830416
ENSG00000137462 tumour 19037923
ENSG00000137462 tumour 19054079
ENSG00000137462 cancer 19109203
ENSG00000137462 tumour 19122641
ENSG00000137462 breast cancer 19141294
ENSG00000137462 tumor 19143470
ENSG00000137462 cancer 19145607
ENSG00000137462 ovarian cancer 19184006
ENSG00000137462 tumour 19250704
ENSG00000137462 tumor 19308683
ENSG00000137462 tumour 19438974
ENSG00000137462 tumor 19474110
ENSG00000137462 cancer 19608024
ENSG00000137462 Tumor 19654875
ENSG00000137462 pancreatic cancer 19685283
ENSG00000137462 tumour 19740307
ENSG00000137462 HNSCCs 19740321
ENSG00000137462 breast cancer 19810822
ENSG00000137462 tumors 19812695
ENSG00000137462 tumour 19930041
ENSG00000137462 tumour 20002372
ENSG00000137462 tumor 20030618
ENSG00000137462 tumour 20070408
ENSG00000137462 cancer 20093776
ENSG00000137462 tumor 20232389
ENSG00000137462 cancer 20380038
ENSG00000137462 oral cavity cancer 20430729
ENSG00000137462 tumor 20449837
ENSG00000137462 tumor 20456615
ENSG00000137462 gallbladder cancer 20492496
ENSG00000137462 cervical cancer 20497180
ENSG00000137462 cancer 20507323
ENSG00000137462 HNSCCs 20514466
ENSG00000137462 Cancer 20520770
ENSG00000137462 cancer 20599915
ENSG00000137462 breast cancer 20618976
ENSG00000137462 tumour 20629986
ENSG00000137462 endometrial cancer 20646321
ENSG00000137462 tumor 20671921
ENSG00000137462 DLBCL 20800061
ENSG00000137462 tumor 20802178
ENSG00000137462 tumor 20807806
ENSG00000137462 bladder cancer 20813668
ENSG00000137462 AML 20814675
ENSG00000137462 tumour 20861291
ENSG00000137462 tumour 20871832
ENSG00000137462 tumor 20885960
ENSG00000137462 tumor 21041732
ENSG00000137462 cancer 21060729
ENSG00000137462 tumor 21068144
ENSG00000137462 breast cancer 21079774
ENSG00000137462 tumor 21106092
ENSG00000137462 gastric cancer 21128061
ENSG00000137462 breast cancer 21149644
ENSG00000137462 HNSCC 21173376
ENSG00000137462 tumour 21179035
ENSG00000137462 tumor 21217015
ENSG00000137462 breast cancer 21264398
ENSG00000137462 cancer 21308921
ENSG00000137462 tumors 21421234
ENSG00000137462 tumour 21446916
ENSG00000137462 tumor 21474175
ENSG00000137462 tumour 21496943
ENSG00000137462 Tumor 21533081
ENSG00000137462 colorectal cancer 21625017
ENSG00000137462 tumour 21789594
ENSG00000137462 colon cancer 21792899
ENSG00000137462 Colon cancer 21822539
ENSG00000137462 colorectal cancer 21845432
ENSG00000137462 tumors 21946568
ENSG00000137462 gastric cancer 21994405
ENSG00000137462 gastric cancer 22041559
ENSG00000137462 tumor 22044500
ENSG00000137462 tumor 22115967
ENSG00000137462 tumour 22133266
ENSG00000137462 tumour 22228906
ENSG00000137462 cancers 22309608
ENSG00000137462 tumor 22320267
ENSG00000137462 tumor 22426694
ENSG00000137462 gastric cancer 22468087
ENSG00000137462 ovarian cancer 22528050
ENSG00000137462 breast cancer 22560646
ENSG00000137462 tumors 22566956
ENSG00000137462 tumor 22649649
ENSG00000137462 Tumor 22649707
ENSG00000137462 tumor 22800462
ENSG00000137462 tumor 22815694
ENSG00000137462 tumor 22859216
ENSG00000137462 tumor 22892451
ENSG00000137462 tumor 22906921
ENSG00000137462 cancer 22934262
ENSG00000137462 tumour 22991262
ENSG00000137462 tumour 23067725
ENSG00000137462 tumor 23079657
ENSG00000137462 pancreatic cancer 23098072
ENSG00000137462 bladder cancer 23142523
ENSG00000137462 Papillary Thyroid Cancer 23166414
ENSG00000137462 Pancreatic cancer 23217280
ENSG00000137462 cancer 23243590
ENSG00000137462 tumor 23284890
ENSG00000137462 cancer 23300722
ENSG00000137462 tumor 23324344
ENSG00000137462 Tumor 23326458
ENSG00000137462 tumour 23379442
ENSG00000137462 Tumor 23424670
ENSG00000137462 tumor 23464467
ENSG00000137462 tumor 23555011
ENSG00000137462 gastric cancer 23565226
ENSG00000137462 cancer 23581420
ENSG00000137462 breast cancer 23643268
ENSG00000137462 tumor 23684552
ENSG00000137462 tumours 23728346
ENSG00000137462 breast cancer 23734974
ENSG00000137462 tumour 23787001
ENSG00000137462 oral cancer 23796347
ENSG00000137462 acute myeloid leukemia (AML) 23852533
ENSG00000137462 tumour 23866094
ENSG00000137462 tumor 23888692
ENSG00000137462 mammary cancer 23970797
ENSG00000137462 bladder cancer 23979666
ENSG00000137462 gastric cancer 24007538
ENSG00000137462 tumors 24014382
ENSG00000137462 tumors 24015628
ENSG00000137462 tumor 24058791
ENSG00000137462 gastric tumors 24069550
ENSG00000137462 cancer 24073361
ENSG00000137462 liver tumors 24098333
ENSG00000137462 tumor 24145436
ENSG00000137462 tumor 24167764
ENSG00000137462 tumor 24199174
ENSG00000137462 tumour 24205107
ENSG00000137462 lung cancer 24211974
ENSG00000137462 cancer 24212952
ENSG00000137462 colorectal cancer 24242044
ENSG00000137462 cancer 24289592
ENSG00000137462 Cancer 24376595
ENSG00000137462 tumour 24387801
ENSG00000137462 colon cancer 24390484
ENSG00000137462 gastric cancer 24454004
ENSG00000137462 gastric cancer 24534481
ENSG00000137462 lung cancer 24630931
ENSG00000137462 cancer 24639717
ENSG00000137462 tumors 24642245
ENSG00000137462 cancer 24659444
ENSG00000137462 gastric tumor 24672653
ENSG00000137462 tumors 24683188
ENSG00000137462 bladder cancer 24688158
ENSG00000137462 metastatic cancer 24731923
ENSG00000137462 tumour 24758719
ENSG00000137462 tumor 24789268
ENSG00000137462 gastric cancer 24833854
ENSG00000137462 tumor 24836676
ENSG00000137462 tumour 24856731
ENSG00000137462 tumor 24871424
ENSG00000137462 tumor 24881218
ENSG00000137462 breast cancer 24904578
ENSG00000137462 tumor 24914341
ENSG00000137462 gastric cancer 24927122
ENSG00000137462 cancer 24950688
ENSG00000137462 cancer 24965109
ENSG00000137462 prostate cancer 24966802
ENSG00000137462 tumour 24976336
ENSG00000137462 Cancer 25034888
ENSG00000137462 gastric tumor 25101079
ENSG00000137462 tumor 25101092
ENSG00000137462 DLBCL 25112836
ENSG00000137462 tumor 25132835
ENSG00000137462 cancer 25175033
ENSG00000137462 cancer 25205638
ENSG00000137462 AML 25283842
ENSG00000137462 tumor 25309546
ENSG00000137462 cancer 25318697
ENSG00000137462 breast cancers 25362351
ENSG00000137462 cervical cancer 25373689
ENSG00000137462 tumor 25380349
ENSG00000137462 tumors 25411122
ENSG00000137462 AML 25412934
ENSG00000137462 colorectal cancer 25435993
ENSG00000137462 tumor 25443743
ENSG00000137462 tumor 25452390
ENSG00000137462 tumor 25483652
ENSG00000137462 tumour 25522970
ENSG00000137462 cancer 25537519
ENSG00000137462 colon cancer 25541970
ENSG00000137462 cancer 25547486
ENSG00000137462 tumor 25596131
ENSG00000137462 cancer 25610736
ENSG00000137462 AML 25624047
ENSG00000137462 brain tumor 25628091
ENSG00000137462 ovarian cancer 25655081
ENSG00000137462 cancer 25723737
ENSG00000137462 cancer 25735793
ENSG00000137462 bone cancer 25744676
ENSG00000137462 tumors 25846753
ENSG00000137462 tumor 25867213
ENSG00000137462 gastric cancer 25880237
ENSG00000137462 Tumor 25934696
ENSG00000137462 tumour 25982946
ENSG00000137462 GBM 26023737
ENSG00000137462 tumor 26045899
ENSG00000137462 gastric cancer 26064948
ENSG00000137462 tumor 26155170
ENSG00000137462 colorectal cancer 26167073
ENSG00000137462 breast cancer 26188904
ENSG00000137462 tumour 26194418
ENSG00000137462 bone cancer 26242124
ENSG00000137462 tumor 26279628
ENSG00000137462 tumour 26290589
ENSG00000137462 Cancer 26332828
ENSG00000137462 TN breast cancer 26392082
ENSG00000137462 tumor 26395101
ENSG00000137462 Cervical Cancer 26548749
ENSG00000137462 cervical cancer 26569074
ENSG00000137462 tumor 26581898
ENSG00000137462 tumor 26598503
ENSG00000137462 tumour 26645352
ENSG00000137462 tumor 26646564
ENSG00000137462 Tumor 26711349
ENSG00000137462 tumor 26785369
ENSG00000137462 tumors 26809278
ENSG00000137462 gastric cancer 26880585
ENSG00000137462 tumor 26888865
ENSG00000137462 cancer 26962463
ENSG00000137462 cancer 26986508
ENSG00000137462 breast cancer 26998146
ENSG00000137462 tumor 27006768
ENSG00000137462 cancer 27021609
ENSG00000137462 tumor 27050526
ENSG00000137462 gastric tumor 27079437
ENSG00000137462 lung tumor 27090786
ENSG00000137462 lung cancer 27097965
ENSG00000137462 tumors 27109786
ENSG00000137462 tumor 27123851
ENSG00000137462 cancer 27127171
ENSG00000137462 tumor 27164542
ENSG00000137462 metastatic colorectal cancer 27196764
ENSG00000137462 tumor 27240347
ENSG00000137462 tumors 27267778
ENSG00000137462 tumour 27270960
ENSG00000137462 tumour 27273587
ENSG00000137462 Tumor 27288077
ENSG00000137462 tumour 27295191
ENSG00000137462 tumor 27336891
ENSG00000137462 AML 27355944
ENSG00000137462 Cancer 27384052
ENSG00000137462 tumor 27492456
ENSG00000137462 tumor 27564262
ENSG00000137462 tumor 27619885
ENSG00000137462 Tumor 27622036
ENSG00000137462 cancer 27693915
ENSG00000137462 tumors 27708223
ENSG00000137462 tumors 27733853
ENSG00000137462 tumour 27737730
ENSG00000137462 Pancreatic Cancer 27941651
ENSG00000137462 cervical cancer 28009429
ENSG00000137462 tumor 28061318
ENSG00000137462 tumor 28076322
ENSG00000137462 cancer 28093329
ENSG00000137462 colorectal cancer 28123896
ENSG00000137462 tumour 28174027
ENSG00000137462 tumor 28184968
ENSG00000137462 pancreatic cancer 28191612
ENSG00000137462 cancer 28216575
ENSG00000137462 tumor 28247866
ENSG00000137462 cancer 28270814
ENSG00000137462 tumour 28300057
ENSG00000137462 lung cancer 28346430
ENSG00000137462 gastric cancer 28368946
ENSG00000137462 breast cancer 28382092
ENSG00000137462 non-small cell lung cancer 28401532
ENSG00000137462 tumor 28415700
ENSG00000137462 tumor 28450804
ENSG00000137462 tumor 28481875
ENSG00000137462 female breast cancer 28490891
ENSG00000137462 Cervical cancer 28497211
ENSG00000137462 tumor 28548063
ENSG00000137462 oral cancer 28624699
ENSG00000137462 lung tumor 28680122
ENSG00000137462 brain tumor 28720549
ENSG00000137462 colorectal cancer 28765705
ENSG00000137462 tumors 28863272
ENSG00000137462 bladder cancer 28881802
ENSG00000137462 AML 28947904
ENSG00000137462 tumor 29027214
ENSG00000137462 tumour 29063667
ENSG00000137462 cancer 29079852
ENSG00000137462 nasopharyngeal cancer 29156866
ENSG00000137462 AML 29181334
ENSG00000137462 cancer 29209524
ENSG00000137462 tumor 29209566
ENSG00000137462 Tumor 29212908
ENSG00000137462 gastric tumors 29230082
ENSG00000137462 Cancer 29276511
ENSG00000137462 tumor 29296526
ENSG00000137462 tumor 29343281
ENSG00000137462 tumor 29428221
ENSG00000137462 tumour 29435195
ENSG00000137462 tumors 29458388
ENSG00000137462 tumor 29467931
ENSG00000137462 tumor 29479437
ENSG00000137462 tumor 29515996
ENSG00000137462 tumor 29553135
ENSG00000137462 colorectal cancer 29566186
ENSG00000137462 tumor 29575556
ENSG00000137462 tumor 29588627
ENSG00000137462 tumor 29593736
ENSG00000137462 tumor 29615080
ENSG00000137462 colorectal cancer 29689497
ENSG00000137462 cancer 29768704
ENSG00000137462 tumour 29848176
ENSG00000137462 tumor 29867942
ENSG00000137462 cancer 29883450
ENSG00000137462 GBM 29912993
ENSG00000137462 tumors 30008925
ENSG00000137462 Colorectal Cancer 30065713
ENSG00000137462 tumor 30131377
ENSG00000137462 tumour 30151234
ENSG00000137462 tumor 30196472
ENSG00000137462 Cervical Cancer 30215163
ENSG00000137462 pancreatic cancer 30246618
ENSG00000137462 gastric cancer 30301709
ENSG00000137462 cancer 30306212
ENSG00000137462 cancers 30357962
ENSG00000137462 gastric cancer 30364936
ENSG00000137462 cancer 30377568
ENSG00000137462 tumor 30429227
ENSG00000137462 cancers 30450666
ENSG00000137462 breast cancers 30517191
ENSG00000137462 tumor 30526680
ENSG00000137462 colon cancer 30532554
ENSG00000137462 tumor 30536754
ENSG00000137462 tumor 30541631
ENSG00000137462 breast cancer 30546963
ENSG00000137462 gastric cancer 30554285
ENSG00000137462 tumours 30598580
ENSG00000137462 tumor 30618413
ENSG00000137462 gastric cancer 30664194
ENSG00000137462 tumors 30679086
ENSG00000137462 tumor 30683309
ENSG00000137462 brain tumor 30720218
ENSG00000137462 tumor 30728901
ENSG00000137462 tumour 30758279
ENSG00000137462 AML-M3 30774831
ENSG00000137462 gastric tumors 30863783
ENSG00000137462 head and neck cancer 30865385
ENSG00000137462 tumors 30880104
ENSG00000137462 cancer 30888638
ENSG00000137462 tumors 30898699
ENSG00000137462 tumor 30936739
ENSG00000137462 tumor 30976817
ENSG00000137462 colon cancer 30987352
ENSG00000137462 tumour 30989203
ENSG00000137462 tumor 31000523
ENSG00000137462 tumor 31019508
ENSG00000137462 cancer 31034495
ENSG00000137462 tumor 31068944
ENSG00000137462 tumor 31118418
ENSG00000137462 tumor 31131189
ENSG00000137462 colorectal cancer 31132191
ENSG00000137462 tumor 31149039
ENSG00000137462 tumor 31167464
ENSG00000137462 lung cancer 31212097
ENSG00000137462 tumour 31238894
ENSG00000137462 tumor 31240216
ENSG00000137462 Tumor 31300052
ENSG00000137462 Tumor 31416850
ENSG00000137462 Cancer 31418565
ENSG00000137462 tumor 31438991
ENSG00000137462 tumor 31443240
ENSG00000137462 bladder cancer 31448424
ENSG00000137462 tumours 31467388
ENSG00000137462 tumour 31505057
ENSG00000137462 tumor 31508424
ENSG00000137462 head and neck cancers 31530984
ENSG00000137462 tumor 31555295
ENSG00000137462 cancer 31558702
ENSG00000137462 liver tumor 31578587
ENSG00000137462 tumor 31590685
ENSG00000137462 tumor 31659256
ENSG00000137462 tumor 31675995
ENSG00000137462 tumor 31695691
ENSG00000137462 cancers 31710083
ENSG00000137462 colon cancer 31746054
ENSG00000137462 tumor 31750245
ENSG00000137462 tumour 31752797
ENSG00000137462 tumour 31822152
ENSG00000137462 AML 31845221
ENSG00000137462 tongue cancer 31911849
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000137462 MESO 0.0015 low
ENSG00000137462 CHOL 0.04 low
ENSG00000137462 UVM 0.033 low
ENSG00000137462 PAAD 0.018 high
ENSG00000137462 UCEC 0.03 high
ENSG00000137462 ACC 0.023 low
ENSG00000137462 LUSC 0.0016 high
ENSG00000137462 KICH 0.046 high
ENSG00000137462 THYM 4e-04 high
ENSG00000137462 OV 0.0021 high
ENSG00000137462 KIRC 0.00014 high
ENSG00000137462 TGCT 0.0012 low
ENSG00000137462 BLCA 0.0085 low
ENSG00000137462 GBM 0.031 high
ENSG00000137462 CESC 0.043 low
ENSG00000137462 LIHC 0.012 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000137462 LUSC Del 4.839820 0.111506 0.383773 0.640719
ENSG00000137462 LUAD Del 0.649615 0.050356 0.290289 0.321705
ENSG00000137462 LGG Del 7.654374 0.091382 0.461100 0.249513
ENSG00000137462 CESC Del 1.788413 0.087713 0.465265 0.369492
ENSG00000137462 COAD Del 1.882582 0.054973 0.418805 0.321508
ENSG00000137462 HNSC Del 4.878058 0.091258 0.365793 0.356322
ENSG00000137462 BLCA Del 3.210600 0.114103 0.373371 0.404412
ENSG00000137462 BRCA Del 1.113305 0.067365 0.384348 0.302778
ENSG00000137462 STAD Del 1.050979 0.065794 0.330460 0.394558
ENSG00000137462 UCEC Del 0.782600 0.048810 0.460218 0.207792
ENSG00000137462 KIRC Del 0.771343 0.025221 0.323430 0.151515
ENSG00000137462 OV Del 7.179692 0.271691 0.622843 0.680484