Ensembl ID ENSG00000137074 Gene ID 54840 Accession 15984
Gene Symbol APTX Alias AOA;AOA1;AXA1;EAOH;EOAHA;FHA-HIT Full Name aprataxin
Position 9 : 32886601 - 33025130 Length 138530 bases Strand Minus strand
Status Confidence Main interacting RNAsdiverseRBP type Canonical_RBPs
Summary This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Aug 2010]

ENSG00000137074 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000137074 APTX 0.52 3.38e-30 BRCA
ENSG00000137074 APTX 0.41 7.17e-11 COAD
ENSG00000137074 APTX 0.84 6.83e-16 LUSC
ENSG00000137074 APTX 0.31 4.95e-11 PRAD
ENSG00000137074 APTX 0.50 1.51e-11 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000137074 APTX tumor 19960345
ENSG00000137074 APTX tumor 20371676
ENSG00000137074 APTX AMLs 22001391
ENSG00000137074 APTX tumors 23517622
ENSG00000137074 APTX gastric tumors 23762305
ENSG00000137074 APTX cancer 26256098
ENSG00000137074 APTX tumor 27769049
ENSG00000137074 APTX cancer 31448237
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000137074 APTX SARC 0.0023 high
ENSG00000137074 APTX UVM 0.0069 high
ENSG00000137074 APTX PAAD 0.003 low
ENSG00000137074 APTX UCEC 0.0021 low
ENSG00000137074 APTX ACC 0.0095 high
ENSG00000137074 APTX LUSC 0.0087 low
ENSG00000137074 APTX READ 0.0067 low
ENSG00000137074 APTX KICH 0.011 high
ENSG00000137074 APTX BRCA 0.03 low
ENSG00000137074 APTX ESCA 0.05 low
ENSG00000137074 APTX OV 0.00068 low
ENSG00000137074 APTX DLBC 0.048 low
ENSG00000137074 APTX BLCA 0.04 low
ENSG00000137074 APTX LAML 0.037 high
ENSG00000137074 APTX CESC 0.02 low
ENSG00000137074 APTX LIHC 0.0025 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000137074 APTX LUSC Amp 6.078516 0.327376 0.672311 0.265469
ENSG00000137074 APTX GBM Del 4.488131 0.088563 0.637676 0.358752
ENSG00000137074 APTX SKCM Del 0.869516 0.069325 0.534583 0.626703
ENSG00000137074 APTX HNSC Amp 1.897189 0.145321 0.606724 0.237548
ENSG00000137074 APTX STAD Amp 0.688077 0.129798 0.500274 0.195011