Ensembl ID ENSG00000136381 Gene ID 3658 Accession 6115
Gene Symbol IREB2 Alias ACO3;IRP2;IRP2AD;NDCAMA;IRE-BP2;IRE-BP2 Full Name iron responsive element binding protein 2
Position 15 : 78437431 - 78501453 Length 64023 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

ENSG00000136381 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000136381 IREB2 lung cancer 15684386
ENSG00000136381 IREB2 lung cancer 17760563
ENSG00000136381 IREB2 lung cancer 18582596
ENSG00000136381 IREB2 tumor 20405006
ENSG00000136381 IREB2 lung cancer 20587604
ENSG00000136381 IREB2 tumour 21348856
ENSG00000136381 IREB2 lung cancer 22093897
ENSG00000136381 IREB2 lung cancer 22539604
ENSG00000136381 IREB2 tumor 24078156
ENSG00000136381 IREB2 breast cancer 24285726
ENSG00000136381 IREB2 lung cancer 25117307
ENSG00000136381 IREB2 lung cancer 25120486
ENSG00000136381 IREB2 tumour 25423073
ENSG00000136381 IREB2 lung cancer 26310313
ENSG00000136381 IREB2 primary cancer 26330360
ENSG00000136381 IREB2 lung cancer 26629341
ENSG00000136381 IREB2 tumors 26797126
ENSG00000136381 IREB2 lung cancer 26981579
ENSG00000136381 IREB2 cancer 28166223
ENSG00000136381 IREB2 lung tumor 28181565
ENSG00000136381 IREB2 colorectal cancer 28281325
ENSG00000136381 IREB2 nonsmall cell lung cancer 28404645
ENSG00000136381 IREB2 tumor 28747430
ENSG00000136381 IREB2 prostate cancer 29137259
ENSG00000136381 IREB2 lung cancer 29187867
ENSG00000136381 IREB2 tumour 30374678
ENSG00000136381 IREB2 cancers 30538952
ENSG00000136381 IREB2 liver cancer 30877170
ENSG00000136381 IREB2 cancer 31332290
ENSG00000136381 IREB2 lung cancer 31696517
ENSG00000136381 IREB2 cancer 31907996
ENSG00000136381 IREB2 cancer 31920398
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000136381 IREB2 SARC 0.041 high
ENSG00000136381 IREB2 UVM 0.021 high
ENSG00000136381 IREB2 UCEC 0.0073 high
ENSG00000136381 IREB2 THCA 0.019 high
ENSG00000136381 IREB2 ACC 0.036 high
ENSG00000136381 IREB2 LGG 0.0037 high
ENSG00000136381 IREB2 LUSC 0.036 low
ENSG00000136381 IREB2 READ 0.0091 low
ENSG00000136381 IREB2 KICH 0.00017 high
ENSG00000136381 IREB2 PCPG 0.03 high
ENSG00000136381 IREB2 THYM 0.018 low
ENSG00000136381 IREB2 BRCA 0.016 high
ENSG00000136381 IREB2 COAD 0.028 high
ENSG00000136381 IREB2 ESCA 0.0057 low
ENSG00000136381 IREB2 OV 0.014 high
ENSG00000136381 IREB2 PRAD 0.029 high
ENSG00000136381 IREB2 LAML 0.00023 low
ENSG00000136381 IREB2 GBM 0.023 low
ENSG00000136381 IREB2 SKCM 0.0048 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000136381 IREB2 CESC Amp 0.660377 0.126318 0.497736 0.247458
ENSG00000136381 IREB2 SKCM Amp 2.397486 0.172914 0.510965 0.310627