Ensembl ID ENSG00000136169 Gene ID 83852 Accession 20263
Gene Symbol SETDB2 Alias CLLD8;CLLL8;KMT1F;C13orf4 Full Name SET domain bifurcated histone lysine methyltransferase 2
Position 13 : 49444274 - 49495003 Length 50730 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

ENSG00000136169 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000136169 SETDB2 -0.5 4.04e-26 BRCA
ENSG00000136169 SETDB2 -0.6 3.50e-18 LUSC
ENSG00000136169 SETDB2 -0.8 2.50e-20 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000136169 SETDB2 cancers 24925220
ENSG00000136169 SETDB2 breast cancers 25537518
ENSG00000136169 SETDB2 gastric cancer 27572307
ENSG00000136169 SETDB2 gastric cancer 28587163
ENSG00000136169 SETDB2 tumor 29099276
ENSG00000136169 SETDB2 cancer 29492189
ENSG00000136169 SETDB2 tumor 29694893
ENSG00000136169 SETDB2 prostate cancer 30616239
ENSG00000136169 SETDB2 cancer 30850015
ENSG00000136169 SETDB2 tumor 31137727
ENSG00000136169 SETDB2 tumor 31341405
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000136169 SETDB2 MESO 0.023 low
ENSG00000136169 SETDB2 SARC 0.00068 low
ENSG00000136169 SETDB2 STAD 0.0082 low
ENSG00000136169 SETDB2 CHOL 0.0069 high
ENSG00000136169 SETDB2 PAAD 0.0015 low
ENSG00000136169 SETDB2 UCEC 0.047 high
ENSG00000136169 SETDB2 LGG 0.004 high
ENSG00000136169 SETDB2 LUSC 0.0036 high
ENSG00000136169 SETDB2 HNSC 0.0028 low
ENSG00000136169 SETDB2 KICH 0.00016 low
ENSG00000136169 SETDB2 PCPG 0.014 low
ENSG00000136169 SETDB2 COAD 0.036 low
ENSG00000136169 SETDB2 KIRC 0.00081 low
ENSG00000136169 SETDB2 SKCM 0.041 high
ENSG00000136169 SETDB2 CESC 0.0094 low
ENSG00000136169 SETDB2 LIHC 0.024 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000136169 SETDB2 LUSC Del 5.805620 0.120366 0.387833 0.686627
ENSG00000136169 SETDB2 LUAD Del 1.614264 0.063155 0.325409 0.540698
ENSG00000136169 SETDB2 LGG Del 7.550010 0.090748 0.468160 0.280702
ENSG00000136169 SETDB2 CESC Del 15.309310 0.219099 0.493563 0.400000
ENSG00000136169 SETDB2 COAD Amp 5.181851 0.143731 0.901357 0.583149
ENSG00000136169 SETDB2 UCS Del 0.891535 0.216530 0.514389 0.571429
ENSG00000136169 SETDB2 SARC Del 36.475781 0.577132 0.711427 0.692607
ENSG00000136169 SETDB2 GBM Del 18.585302 0.171310 0.590453 0.426343
ENSG00000136169 SETDB2 THCA Del 1.956122 0.015404 0.600533 0.038076
ENSG00000136169 SETDB2 HNSC Del 11.843736 0.131494 0.411018 0.408046
ENSG00000136169 SETDB2 LIHC Del 25.992268 0.273881 0.615379 0.481081
ENSG00000136169 SETDB2 DLBC Del 0.674520 0.124054 0.570095 0.145833
ENSG00000136169 SETDB2 BLCA Del 28.850617 0.303567 0.487387 0.377451
ENSG00000136169 SETDB2 BRCA Del 18.986316 0.145556 0.498771 0.459259
ENSG00000136169 SETDB2 PRAD Del 65.892222 0.387289 0.541747 0.443089
ENSG00000136169 SETDB2 UCEC Del 1.363670 0.056442 0.545040 0.194805
ENSG00000136169 SETDB2 MESO Del 1.029587 0.138131 0.464410 0.471264
ENSG00000136169 SETDB2 KIRC Del 0.719382 0.024606 0.354816 0.153409
ENSG00000136169 SETDB2 OV Del 6.367625 0.262716 0.641584 0.620035