Ensembl ID
ENSG00000136104
Gene ID
79621
Accession
25671
Gene Symbol
RNASEH2B
Alias
AGS2;DLEU8
Full Name
ribonuclease H2 subunit B
Position
13 : 50909747 - 51024120
Length
114374 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs diverse RBP type
Canonical_RBPs
Summary
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
ENSG00000136104 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000136104
RNASEH2B
0.85
7.32e-18
COAD
ENSG00000136104
RNASEH2B
-0.4
6.82e-11
PRAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000136104
RNASEH2B
cancer
26603688
ENSG00000136104
RNASEH2B
colorectal cancer
27988520
ENSG00000136104
RNASEH2B
tumor
29030706
ENSG00000136104
RNASEH2B
metastatic prostate cancer
29973717
ENSG00000136104
RNASEH2B
colorectal tumor
30273559
ENSG00000136104
RNASEH2B
Cancer
30532030
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000136104
RNASEH2B
SARC
0.0045
low
show
ENSG00000136104
RNASEH2B
UVM
0.00052
high
show
ENSG00000136104
RNASEH2B
UCEC
0.05
high
show
ENSG00000136104
RNASEH2B
THCA
0.014
low
show
ENSG00000136104
RNASEH2B
LGG
0.038
low
show
ENSG00000136104
RNASEH2B
READ
0.013
high
show
ENSG00000136104
RNASEH2B
KIRP
0.0049
high
show
ENSG00000136104
RNASEH2B
KICH
0.014
high
show
ENSG00000136104
RNASEH2B
LUAD
0.04
low
show
ENSG00000136104
RNASEH2B
THYM
0.00031
low
show
ENSG00000136104
RNASEH2B
BRCA
0.038
low
show
ENSG00000136104
RNASEH2B
COAD
0.016
low
show
ENSG00000136104
RNASEH2B
ESCA
0.022
high
show
ENSG00000136104
RNASEH2B
OV
0.028
high
show
ENSG00000136104
RNASEH2B
DLBC
0.0067
low
show
ENSG00000136104
RNASEH2B
KIRC
0.00013
high
show
ENSG00000136104
RNASEH2B
PRAD
0.03
low
show
ENSG00000136104
RNASEH2B
LAML
0.00019
low
show
ENSG00000136104
RNASEH2B
SKCM
0.00022
low
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000136104
RNASEH2B
LUSC
Del
5.417939
0.116909
0.386877
0.686627
ENSG00000136104
RNASEH2B
LUAD
Del
1.832460
0.065463
0.325267
0.536822
ENSG00000136104
RNASEH2B
LGG
Del
8.261839
0.094758
0.469035
0.280702
ENSG00000136104
RNASEH2B
CESC
Del
14.738907
0.214695
0.488799
0.393220
ENSG00000136104
RNASEH2B
SARC
Del
28.744018
0.502990
0.676299
0.680934
ENSG00000136104
RNASEH2B
GBM
Del
20.145467
0.178816
0.591079
0.431542
ENSG00000136104
RNASEH2B
THCA
Del
1.956122
0.016055
0.600533
0.038076
ENSG00000136104
RNASEH2B
HNSC
Del
9.901735
0.121124
0.407398
0.406130
ENSG00000136104
RNASEH2B
LIHC
Del
25.326114
0.269785
0.616225
0.478378
ENSG00000136104
RNASEH2B
DLBC
Del
0.707315
0.124054
0.570095
0.145833
ENSG00000136104
RNASEH2B
BLCA
Del
28.457525
0.301178
0.487248
0.370098
ENSG00000136104
RNASEH2B
BRCA
Del
18.801328
0.144955
0.498885
0.459259
ENSG00000136104
RNASEH2B
PRAD
Del
65.639341
0.386189
0.541110
0.445122
ENSG00000136104
RNASEH2B
MESO
Del
1.053172
0.138131
0.465176
0.471264
ENSG00000136104
RNASEH2B
KIRC
Del
0.746692
0.024811
0.358704
0.155303
ENSG00000136104
RNASEH2B
OV
Del
6.487389
0.264024
0.634400
0.621762
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