Ensembl ID ENSG00000136068 Gene ID 2317 Accession 3755
Gene Symbol FLNB Alias AOI;FH1;SCT;TAP;LRS1;TABP;FLN-B;FLN1L;ABP-278;ABP-280 Full Name filamin B
Position 3 : 58008398 - 58172251 Length 163854 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

ENSG00000136068 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000136068 FLNB -1.0 2.03e-23 COAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000136068 FLNB tumors 16026007
ENSG00000136068 FLNB tumor 20219242
ENSG00000136068 FLNB tumours 21630274
ENSG00000136068 FLNB tumor 21954183
ENSG00000136068 FLNB kidney cancers 22645311
ENSG00000136068 FLNB cancer 23340843
ENSG00000136068 FLNB cancer 23543272
ENSG00000136068 FLNB tumours 23766440
ENSG00000136068 FLNB tumor 24280230
ENSG00000136068 FLNB tumor 25244493
ENSG00000136068 FLNB breast cancer 25454514
ENSG00000136068 FLNB tumour 25613188
ENSG00000136068 FLNB Cancer 25925610
ENSG00000136068 FLNB renal cancer 27774467
ENSG00000136068 FLNB giant cell tumor 27779699
ENSG00000136068 FLNB cancer 28031525
ENSG00000136068 FLNB tumor 28251929
ENSG00000136068 FLNB prostate cancer 28344825
ENSG00000136068 FLNB ovarian cancer 28538838
ENSG00000136068 FLNB Prostate Cancer 29682400
ENSG00000136068 FLNB COAD 29900123
ENSG00000136068 FLNB breast cancer 30059005
ENSG00000136068 FLNB tumour 30202019
ENSG00000136068 FLNB tumor 30301907
ENSG00000136068 FLNB Cancer 30862794
ENSG00000136068 FLNB GBM 30867563
ENSG00000136068 FLNB prostate cancer 31013716
ENSG00000136068 FLNB breast cancer 31128301
ENSG00000136068 FLNB tumor 31299979
ENSG00000136068 FLNB pancreatic cancer 31358530
ENSG00000136068 FLNB tumours 31478829
ENSG00000136068 FLNB ovarian cancer 31829305
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000136068 FLNB MESO 1e-04 high
ENSG00000136068 FLNB STAD 0.042 low
ENSG00000136068 FLNB UVM 0.0085 low
ENSG00000136068 FLNB THCA 0.0053 high
ENSG00000136068 FLNB LGG 0.0018 low
ENSG00000136068 FLNB READ 0.00047 low
ENSG00000136068 FLNB KIRP 0.0026 low
ENSG00000136068 FLNB LUAD 0.02 high
ENSG00000136068 FLNB THYM 0.00062 low
ENSG00000136068 FLNB BRCA 0.0082 high
ENSG00000136068 FLNB ESCA 0.00099 low
ENSG00000136068 FLNB OV 2e-04 high
ENSG00000136068 FLNB KIRC 0.0025 low
ENSG00000136068 FLNB LAML 0.0041 high
ENSG00000136068 FLNB SKCM 0.033 high
ENSG00000136068 FLNB CESC 0.012 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000136068 FLNB LUSC Del 6.652160 0.126633 0.418886 0.862275
ENSG00000136068 FLNB LUAD Del 0.772228 0.052244 0.325052 0.463178
ENSG00000136068 FLNB CESC Del 2.398697 0.097622 0.544804 0.430508
ENSG00000136068 FLNB COAD Del 0.771756 0.042970 0.423244 0.155211
ENSG00000136068 FLNB UCS Del 3.000944 0.369261 0.554688 0.642857
ENSG00000136068 FLNB SARC Del 1.045496 0.131856 0.510888 0.249027
ENSG00000136068 FLNB ESCA Del 1.843851 0.128859 0.444067 0.684783
ENSG00000136068 FLNB HNSC Del 1.048977 0.058488 0.438817 0.716475
ENSG00000136068 FLNB LIHC Del 0.661383 0.064374 0.438340 0.181081
ENSG00000136068 FLNB BLCA Del 6.815045 0.151783 0.419911 0.279412
ENSG00000136068 FLNB BRCA Del 26.523836 0.167410 0.468091 0.306481
ENSG00000136068 FLNB STAD Del 2.812869 0.087889 0.332208 0.326531
ENSG00000136068 FLNB UCEC Del 2.789249 0.070704 0.510592 0.141002
ENSG00000136068 FLNB MESO Del 7.334359 0.331017 0.538314 0.367816
ENSG00000136068 FLNB KIRC Del 21.715714 0.103549 0.513182 0.820076