Ensembl ID ENSG00000135297 Gene ID 25821 Accession 19261
Gene Symbol MTO1 Alias CGI-02;COXPD10 Full Name mitochondrial tRNA translation optimization 1
Position 6 : 73461578 - 73509236 Length 47659 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000135297 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000135297 MTO1 -0.4 1.01e-23 KIRC
ENSG00000135297 MTO1 -0.2 9.28e-12 PRAD
ENSG00000135297 MTO1 -0.5 5.03e-13 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000135297 MTO1 breast cancer 24160266
ENSG00000135297 MTO1 breast cancer 30015883
ENSG00000135297 MTO1 cancer 30975029
ENSG00000135297 MTO1 tumor 31148365
ENSG00000135297 MTO1 gastric cancer 31556152
ENSG00000135297 MTO1 prostate cancer 31713278
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000135297 MTO1 SARC 0.03 high
ENSG00000135297 MTO1 UVM 0.033 high
ENSG00000135297 MTO1 PAAD 0.011 low
ENSG00000135297 MTO1 UCEC 0.029 high
ENSG00000135297 MTO1 THCA 0.00019 high
ENSG00000135297 MTO1 LGG 0.005 high
ENSG00000135297 MTO1 HNSC 0.02 low
ENSG00000135297 MTO1 READ 0.00051 low
ENSG00000135297 MTO1 KICH 0.0013 high
ENSG00000135297 MTO1 LUAD 0.027 low
ENSG00000135297 MTO1 THYM 0.0032 low
ENSG00000135297 MTO1 BRCA 0.024 high
ENSG00000135297 MTO1 OV 0.0048 low
ENSG00000135297 MTO1 DLBC 0.011 high
ENSG00000135297 MTO1 KIRC 0.00023 low
ENSG00000135297 MTO1 LAML 0.033 high
ENSG00000135297 MTO1 CESC 0.0041 low
ENSG00000135297 MTO1 LIHC 0.0089 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000135297 MTO1 CHOL Del 0.840293 0.216530 0.629156 0.555556
ENSG00000135297 MTO1 LUAD Del 0.611734 0.049726 0.368452 0.434109
ENSG00000135297 MTO1 SARC Del 1.397606 0.141966 0.460130 0.280156
ENSG00000135297 MTO1 BRCA Del 1.590459 0.071375 0.462642 0.275000
ENSG00000135297 MTO1 PRAD Del 11.169385 0.156456 0.496135 0.201220