Ensembl ID ENSG00000134905 Gene ID 79587 Accession 25695
Gene Symbol CARS2 Alias cysRS;COXPD27 Full Name cysteinyl-tRNA synthetase 2, mitochondrial
Position 13 : 110641417 - 110706133 Length 64717 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]

ENSG00000134905 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000134905 CARS2 0.47 1.52e-11 KIRC
ENSG00000134905 CARS2 0.98 6.95e-24 COAD
ENSG00000134905 CARS2 0.93 1.55e-18 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000134905 CARS2 MESO 0.011 low
ENSG00000134905 CARS2 STAD 0.031 low
ENSG00000134905 CARS2 CHOL 0.037 high
ENSG00000134905 CARS2 UVM 0.013 low
ENSG00000134905 CARS2 PAAD 0.0018 low
ENSG00000134905 CARS2 UCEC 0.00014 low
ENSG00000134905 CARS2 ACC 0.046 high
ENSG00000134905 CARS2 LGG 0.00052 high
ENSG00000134905 CARS2 HNSC 0.0032 high
ENSG00000134905 CARS2 READ 0.039 high
ENSG00000134905 CARS2 KICH 0.00095 high
ENSG00000134905 CARS2 BRCA 0.0026 low
ENSG00000134905 CARS2 ESCA 0.029 high
ENSG00000134905 CARS2 BLCA 0.029 low
ENSG00000134905 CARS2 SKCM 0.00019 high
ENSG00000134905 CARS2 LIHC 0.00025 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000134905 CARS2 LUAD Amp 0.703978 0.116804 0.486153 0.139535
ENSG00000134905 CARS2 LGG Amp 0.806661 0.045343 0.712462 0.035088
ENSG00000134905 CARS2 CESC Amp 3.416042 0.223605 0.562510 0.233898
ENSG00000134905 CARS2 READ Amp 2.171060 0.197092 1.034940 0.715152
ENSG00000134905 CARS2 COAD Amp 6.471541 0.163111 0.936586 0.580931
ENSG00000134905 CARS2 SARC Amp 0.989551 0.276479 0.779824 0.175097
ENSG00000134905 CARS2 HNSC Amp 1.779082 0.142689 0.464161 0.201149
ENSG00000134905 CARS2 LIHC Amp 9.100523 0.275083 0.814444 0.183784
ENSG00000134905 CARS2 BLCA Amp 1.912612 0.206891 0.514523 0.343137
ENSG00000134905 CARS2 BRCA Amp 1.529626 0.161988 0.613184 0.160185
ENSG00000134905 CARS2 STAD Amp 1.207457 0.147515 0.570297 0.383220
ENSG00000134905 CARS2 UCEC Amp 0.796171 0.105427 0.677936 0.109462