Ensembl ID ENSG00000134760 Gene ID 1828 Accession 3048
Gene Symbol DSG1 Alias DG1;DSG;CDHF4;EPKHE;PPKS1;SPPK1;EPKHIA Full Name desmoglein 1
Position 18 : 31318160 - 31359246 Length 41087 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]

ENSG00000134760 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000134760 DSG1 2.20 1.07e-20 COAD
ENSG00000134760 DSG1 5.21 1.42e-47 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000134760 DSG1 tumor 11781826
ENSG00000134760 DSG1 tumors 12210023
ENSG00000134760 DSG1 tumors 12530024
ENSG00000134760 DSG1 tumor 14744087
ENSG00000134760 DSG1 thyroid cancer 15861465
ENSG00000134760 DSG1 cancer 17699853
ENSG00000134760 DSG1 pancreatic cancer 19091121
ENSG00000134760 DSG1 tumors 20975948
ENSG00000134760 DSG1 tumors 21556543
ENSG00000134760 DSG1 cancer 22333708
ENSG00000134760 DSG1 oral cancer 24849508
ENSG00000134760 DSG1 lung cancer 25468811
ENSG00000134760 DSG1 tumour 25754262
ENSG00000134760 DSG1 tumour 26469831
ENSG00000134760 DSG1 tumours 27374210
ENSG00000134760 DSG1 tumors 28991255
ENSG00000134760 DSG1 HNSCC 30655320
ENSG00000134760 DSG1 thyroid cancer 31073526
ENSG00000134760 DSG1 esophageal cancer 7934060
ENSG00000134760 DSG1 tumour 9062412
ENSG00000134760 DSG1 esophageal cancer 9844796
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000134760 DSG1 MESO 0.033 high
ENSG00000134760 DSG1 SARC 0.05 low
ENSG00000134760 DSG1 THCA 0.045 high
ENSG00000134760 DSG1 LUSC 0.024 low
ENSG00000134760 DSG1 HNSC 0.0074 low
ENSG00000134760 DSG1 KIRP 0.0036 high
ENSG00000134760 DSG1 LUAD 0.02 high
ENSG00000134760 DSG1 BRCA 0.018 low
ENSG00000134760 DSG1 OV 0.016 low
ENSG00000134760 DSG1 DLBC 0.01 high
ENSG00000134760 DSG1 BLCA 0.00031 high
ENSG00000134760 DSG1 LIHC 0.013 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000134760 DSG1 PAAD Del 1.347110 0.058840 0.380998 0.586957
ENSG00000134760 DSG1 STAD Del 1.463610 0.071686 0.399932 0.353741