Ensembl ID ENSG00000134684 Gene ID 8565 Accession 12840
Gene Symbol YARS1 Alias YRS;YTS;YARS;TYRRS;CMTDIC;IMNEPD2 Full Name tyrosyl-tRNA synthetase 1
Position 1 : 32775239 - 32818031 Length 42793 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]

ENSG00000134684 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000134684 YARS1 0.39 5.85e-14 KIRC
ENSG00000134684 YARS1 0.72 2.00e-36 BRCA
ENSG00000134684 YARS1 0.89 4.29e-29 COAD
ENSG00000134684 YARS1 0.85 7.98e-14 KICH
ENSG00000134684 YARS1 0.52 6.53e-15 LUSC
ENSG00000134684 YARS1 1.02 2.14e-27 UCEC
ENSG00000134684 YARS1 0.60 1.88e-21 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000134684 YARS1 cancer 24510587
ENSG00000134684 YARS1 gastric cancer 31912229
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000134684 YARS1 SARC 0.0067 high
ENSG00000134684 YARS1 STAD 0.0017 low
ENSG00000134684 YARS1 UVM 0.018 high
ENSG00000134684 YARS1 PAAD 0.0015 high
ENSG00000134684 YARS1 UCEC 0.049 low
ENSG00000134684 YARS1 THCA 0.032 low
ENSG00000134684 YARS1 ACC 0.00043 high
ENSG00000134684 YARS1 LGG 0.00074 high
ENSG00000134684 YARS1 LUSC 0.047 high
ENSG00000134684 YARS1 HNSC 0.0035 high
ENSG00000134684 YARS1 READ 0.036 low
ENSG00000134684 YARS1 PCPG 0.05 low
ENSG00000134684 YARS1 PRAD 0.0016 low
ENSG00000134684 YARS1 BLCA 0.0019 high
ENSG00000134684 YARS1 LAML 0.019 high
ENSG00000134684 YARS1 SKCM 0.042 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000134684 YARS1 CHOL Del 7.967105 0.613502 0.654079 0.527778
ENSG00000134684 YARS1 KIRP Del 3.807760 0.055636 0.586110 0.163194
ENSG00000134684 YARS1 READ Del 2.350065 0.110890 0.418574 0.381818
ENSG00000134684 YARS1 COAD Del 5.446032 0.083779 0.423835 0.299335
ENSG00000134684 YARS1 LIHC Del 11.042067 0.173809 0.533089 0.345946
ENSG00000134684 YARS1 PCPG Del 1.928038 0.084206 0.673439 0.623457
ENSG00000134684 YARS1 BRCA Del 4.776018 0.091424 0.388984 0.332407
ENSG00000134684 YARS1 STAD Del 0.760311 0.061375 0.328012 0.197279
ENSG00000134684 YARS1 UCEC Del 1.706404 0.060460 0.424700 0.083488
ENSG00000134684 YARS1 KIRC Del 2.792716 0.036703 0.415416 0.164773
ENSG00000134684 YARS1 UVM Del 1.063142 0.073079 0.771526 0.312500
ENSG00000134684 YARS1 OV Amp 1.546247 0.359475 0.627528 0.364421
ENSG00000134684 YARS1 OV Del 2.871539 0.217278 0.516988 0.255613