Ensembl ID ENSG00000134318 Gene ID 9475 Accession 10252
Gene Symbol ROCK2 Alias ROCK-II Full Name Rho associated coiled-coil containing protein kinase 2
Position 2 : 11179759 - 11344636 Length 164878 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

ENSG00000134318 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000134318 ROCK2 -1.3 3.36e-23 BLCA
ENSG00000134318 ROCK2 -0.9 1.00e-45 BRCA
ENSG00000134318 ROCK2 -0.6 1.14e-16 LUSC
ENSG00000134318 ROCK2 -0.6 3.23e-19 PRAD
ENSG00000134318 ROCK2 -1.1 6.05e-29 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000134318 ROCK2 tumor 15269155
ENSG00000134318 ROCK2 tumors 15604264
ENSG00000134318 ROCK2 colon cancer 17876296
ENSG00000134318 ROCK2 breast cancer 18695890
ENSG00000134318 ROCK2 tumor 19205033
ENSG00000134318 ROCK2 cancer 19391117
ENSG00000134318 ROCK2 breast cancer 20939434
ENSG00000134318 ROCK2 breast cancer 21084279
ENSG00000134318 ROCK2 tumor 21665151
ENSG00000134318 ROCK2 tumour 21672940
ENSG00000134318 ROCK2 HNSCC 21770894
ENSG00000134318 ROCK2 tumor 22093931
ENSG00000134318 ROCK2 cancer 22167443
ENSG00000134318 ROCK2 tumours 22273145
ENSG00000134318 ROCK2 cancer 22510280
ENSG00000134318 ROCK2 cancer 22846914
ENSG00000134318 ROCK2 tumor 22934846
ENSG00000134318 ROCK2 non-small cell lung cancer 22942252
ENSG00000134318 ROCK2 cancers 23044996
ENSG00000134318 ROCK2 cancer 23204112
ENSG00000134318 ROCK2 cancer 23319410
ENSG00000134318 ROCK2 cancers 23340525
ENSG00000134318 ROCK2 tumour 23644663
ENSG00000134318 ROCK2 cancer 23702041
ENSG00000134318 ROCK2 tumour 24169343
ENSG00000134318 ROCK2 cancer 24330780
ENSG00000134318 ROCK2 tumor 24336634
ENSG00000134318 ROCK2 cancers 24405853
ENSG00000134318 ROCK2 cancers 24552547
ENSG00000134318 ROCK2 tumor 24905316
ENSG00000134318 ROCK2 tumor 24908363
ENSG00000134318 ROCK2 colorectal cancer 24942287
ENSG00000134318 ROCK2 tumor 24992025
ENSG00000134318 ROCK2 prostate cancer 25065599
ENSG00000134318 ROCK2 breast cancer 25288205
ENSG00000134318 ROCK2 cancer 25677806
ENSG00000134318 ROCK2 breast cancer 25686838
ENSG00000134318 ROCK2 tumor 25755711
ENSG00000134318 ROCK2 tumor 25912304
ENSG00000134318 ROCK2 tumor 26136223
ENSG00000134318 ROCK2 cancer 26146543
ENSG00000134318 ROCK2 breast cancer 26377148
ENSG00000134318 ROCK2 tumor 26460959
ENSG00000134318 ROCK2 invasive breast cancer 26626121
ENSG00000134318 ROCK2 breast cancer 26657485
ENSG00000134318 ROCK2 cancer 26725045
ENSG00000134318 ROCK2 tumor 26765561
ENSG00000134318 ROCK2 cancer 26826790
ENSG00000134318 ROCK2 liver cancer 26846339
ENSG00000134318 ROCK2 Blood-Tumor 26903801
ENSG00000134318 ROCK2 tumours 26950944
ENSG00000134318 ROCK2 cancer 27017918
ENSG00000134318 ROCK2 cancer 27203208
ENSG00000134318 ROCK2 tumor 27213590
ENSG00000134318 ROCK2 lung cancer 27229528
ENSG00000134318 ROCK2 prostate cancer 27323416
ENSG00000134318 ROCK2 cancer 27354305
ENSG00000134318 ROCK2 tumors 27597870
ENSG00000134318 ROCK2 pancreatic cancer 27824338
ENSG00000134318 ROCK2 gastric cancer 27921230
ENSG00000134318 ROCK2 tumour 27991921
ENSG00000134318 ROCK2 pancreatic tumors 28031255
ENSG00000134318 ROCK2 tumor 28112365
ENSG00000134318 ROCK2 tumour 28367203
ENSG00000134318 ROCK2 Tumor 28388926
ENSG00000134318 ROCK2 tumor 28554330
ENSG00000134318 ROCK2 tumors 28653604
ENSG00000134318 ROCK2 tumor 28670628
ENSG00000134318 ROCK2 tumors 28709411
ENSG00000134318 ROCK2 tumor 28721163
ENSG00000134318 ROCK2 tumors 28938647
ENSG00000134318 ROCK2 tumor 28972449
ENSG00000134318 ROCK2 tumors 29052912
ENSG00000134318 ROCK2 tumors 29416017
ENSG00000134318 ROCK2 tumors 29434937
ENSG00000134318 ROCK2 tumors 29472430
ENSG00000134318 ROCK2 tumor 29535813
ENSG00000134318 ROCK2 breast cancer 29990315
ENSG00000134318 ROCK2 GBM 30071868
ENSG00000134318 ROCK2 cancer 30117678
ENSG00000134318 ROCK2 tumor 30266988
ENSG00000134318 ROCK2 cancer 30413785
ENSG00000134318 ROCK2 bladder cancer 30475758
ENSG00000134318 ROCK2 gastric cancers 30514953
ENSG00000134318 ROCK2 breast cancer 30719106
ENSG00000134318 ROCK2 breast cancer 30771534
ENSG00000134318 ROCK2 tumours 30788085
ENSG00000134318 ROCK2 cancer 30804013
ENSG00000134318 ROCK2 tumor 30816534
ENSG00000134318 ROCK2 prostate cancer 31026254
ENSG00000134318 ROCK2 gastric cancer 31273599
ENSG00000134318 ROCK2 cancer 31363382
ENSG00000134318 ROCK2 prostate cancer 31431478
ENSG00000134318 ROCK2 cervical cancer 31488179
ENSG00000134318 ROCK2 bladder cancer 31620199
ENSG00000134318 ROCK2 Pancreatic Cancer 31783584
ENSG00000134318 ROCK2 tumor 31878963
ENSG00000134318 ROCK2 metastatic tumors 31888022
ENSG00000134318 ROCK2 cancer 31922232
ENSG00000134318 ROCK2 tumor 31933730
ENSG00000134318 ROCK2 tumor 31933931
ENSG00000134318 ROCK2 cancer 31966061
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000134318 ROCK2 PAAD 0.043 high
ENSG00000134318 ROCK2 UCEC 0.049 high
ENSG00000134318 ROCK2 THCA 0.022 high
ENSG00000134318 ROCK2 ACC 0.00017 high
ENSG00000134318 ROCK2 LGG 0.00014 high
ENSG00000134318 ROCK2 KIRP 0.00014 high
ENSG00000134318 ROCK2 KICH 0.025 high
ENSG00000134318 ROCK2 THYM 0.028 low
ENSG00000134318 ROCK2 BRCA 0.033 high
ENSG00000134318 ROCK2 COAD 0.00096 low
ENSG00000134318 ROCK2 BLCA 0.013 high
ENSG00000134318 ROCK2 LAML 0.0076 low
ENSG00000134318 ROCK2 SKCM 0.0018 low
ENSG00000134318 ROCK2 CESC 0.013 high
ENSG00000134318 ROCK2 LIHC 0.015 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000134318 ROCK2 LIHC Amp 2.112103 0.148644 0.556562 0.178378
ENSG00000134318 ROCK2 TGCT Amp 1.690985 0.162419 0.462090 0.380000
ENSG00000134318 ROCK2 UCEC Amp 0.650347 0.101326 0.574787 0.211503