Ensembl ID ENSG00000134283 Gene ID 51535 Accession 19369
Gene Symbol PPHLN1 Alias CR;HSPC206;HSPC232 Full Name periphilin 1
Position 12 : 42238447 - 42459715 Length 221269 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

ENSG00000134283 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000134283 PPHLN1 0.31 1.34e-18 KIRC
ENSG00000134283 PPHLN1 0.23 1.48e-11 BRCA
ENSG00000134283 PPHLN1 0.48 1.23e-17 LUSC
ENSG00000134283 PPHLN1 0.50 9.68e-17 KIRP
ENSG00000134283 PPHLN1 0.38 5.73e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000134283 PPHLN1 tumors 27245147
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000134283 PPHLN1 MESO 0.0092 high
ENSG00000134283 PPHLN1 SARC 0.045 low
ENSG00000134283 PPHLN1 UCEC 0.038 high
ENSG00000134283 PPHLN1 THCA 0.003 low
ENSG00000134283 PPHLN1 ACC 0.014 high
ENSG00000134283 PPHLN1 LUSC 0.05 low
ENSG00000134283 PPHLN1 HNSC 0.02 high
ENSG00000134283 PPHLN1 READ 0.026 low
ENSG00000134283 PPHLN1 KIRP 0.018 high
ENSG00000134283 PPHLN1 KICH 0.02 high
ENSG00000134283 PPHLN1 LUAD 0.05 high
ENSG00000134283 PPHLN1 THYM 7e-04 low
ENSG00000134283 PPHLN1 BRCA 0.044 high
ENSG00000134283 PPHLN1 UCS 0.037 low
ENSG00000134283 PPHLN1 ESCA 0.05 high
ENSG00000134283 PPHLN1 OV 0.0033 low
ENSG00000134283 PPHLN1 DLBC 0.038 high
ENSG00000134283 PPHLN1 KIRC 0.0023 high
ENSG00000134283 PPHLN1 PRAD 0.0014 high
ENSG00000134283 PPHLN1 BLCA 0.014 low
ENSG00000134283 PPHLN1 SKCM 0.038 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000134283 PPHLN1 LGG Del 2.943489 0.060358 0.446578 0.132554
ENSG00000134283 PPHLN1 GBM Del 2.106187 0.068299 0.519065 0.131716