Ensembl ID ENSG00000134030 Gene ID 9811 Accession 23925
Gene Symbol CTIF Alias Gm672;KIAA0427 Full Name cap binding complex dependent translation initiation factor
Position 18 : 48539031 - 48863217 Length 324187 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

ENSG00000134030 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000134030 CTIF -0.7 4.33e-35 KIRC
ENSG00000134030 CTIF -1.1 4.06e-14 BLCA
ENSG00000134030 CTIF -1.1 2.27e-63 BRCA
ENSG00000134030 CTIF -1.0 7.51e-25 LUSC
ENSG00000134030 CTIF -0.5 1.12e-12 PRAD
ENSG00000134030 CTIF -2.3 2.76e-15 GBM
ENSG00000134030 CTIF -1.0 2.09e-27 KIRP
ENSG00000134030 CTIF -1.1 1.83e-25 UCEC
ENSG00000134030 CTIF -1.6 6.64e-12 ESCA
ENSG00000134030 CTIF -1.2 3.42e-43 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000134030 CTIF SARC 0.046 low
ENSG00000134030 CTIF UVM 0.0038 high
ENSG00000134030 CTIF PAAD 0.0023 low
ENSG00000134030 CTIF UCEC 0.019 high
ENSG00000134030 CTIF THCA 0.0032 high
ENSG00000134030 CTIF LUSC 0.0023 high
ENSG00000134030 CTIF READ 0.0088 low
ENSG00000134030 CTIF KIRP 0.00076 low
ENSG00000134030 CTIF THYM 0.022 high
ENSG00000134030 CTIF UCS 0.044 high
ENSG00000134030 CTIF ESCA 0.028 low
ENSG00000134030 CTIF OV 0.0012 high
ENSG00000134030 CTIF DLBC 0.044 low
ENSG00000134030 CTIF BLCA 0.0044 high
ENSG00000134030 CTIF LAML 0.0068 low
ENSG00000134030 CTIF SKCM 0.05 low
ENSG00000134030 CTIF LIHC 0.049 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000134030 CTIF LUAD Del 2.861385 0.075534 0.374472 0.482558
ENSG00000134030 CTIF READ Del 1.009044 0.080707 0.632871 0.854545
ENSG00000134030 CTIF COAD Del 2.163705 0.057853 0.612844 0.605322
ENSG00000134030 CTIF PAAD Del 2.426462 0.077668 0.398700 0.679348
ENSG00000134030 CTIF ESCA Del 3.410090 0.165928 0.480540 0.614130
ENSG00000134030 CTIF HNSC Del 1.086188 0.058903 0.403945 0.480843
ENSG00000134030 CTIF LIHC Del 0.838879 0.067592 0.527394 0.251351
ENSG00000134030 CTIF STAD Del 8.787342 0.137725 0.427818 0.430839
ENSG00000134030 CTIF OV Del 2.536466 0.211855 0.622914 0.564767