Ensembl ID
ENSG00000134001
Gene ID
1965
Accession
3265
Gene Symbol
EIF2S1
Alias
EIF2;EIF-2;EIF2A;EIF-2A;EIF-2alpha
Full Name
eukaryotic translation initiation factor 2 subunit alpha
Position
14 : 67360328 - 67386516
Length
26189 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs tRNA RBP type
Canonical_RBPs
Summary
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
ENSG00000134001 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000134001
EIF2S1
0.56
7.33e-15
KICH
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000134001
EIF2S1
tumour
10432301
ENSG00000134001
EIF2S1
tumor
10497873
ENSG00000134001
EIF2S1
tumor
10558914
ENSG00000134001
EIF2S1
tumours
10841309
ENSG00000134001
EIF2S1
cancer
11101152
ENSG00000134001
EIF2S1
tumor
11333223
ENSG00000134001
EIF2S1
tumor
11447118
ENSG00000134001
EIF2S1
lung cancer
11956076
ENSG00000134001
EIF2S1
thyroid cancer
12186496
ENSG00000134001
EIF2S1
cancer
12214268
ENSG00000134001
EIF2S1
tumor
12706348
ENSG00000134001
EIF2S1
tumour
15094767
ENSG00000134001
EIF2S1
tumor
15178489
ENSG00000134001
EIF2S1
cancer
15456240
ENSG00000134001
EIF2S1
Tumor
16124003
ENSG00000134001
EIF2S1
prostate cancer
16204082
ENSG00000134001
EIF2S1
tumors
16472113
ENSG00000134001
EIF2S1
tumor
16861899
ENSG00000134001
EIF2S1
tumor
17113348
ENSG00000134001
EIF2S1
cancer
17213191
ENSG00000134001
EIF2S1
tumor
17215292
ENSG00000134001
EIF2S1
tumor
17283163
ENSG00000134001
EIF2S1
tumour
17341295
ENSG00000134001
EIF2S1
tumour
17387345
ENSG00000134001
EIF2S1
cancer
17531337
ENSG00000134001
EIF2S1
tumour
17623010
ENSG00000134001
EIF2S1
tumor
17637831
ENSG00000134001
EIF2S1
cancer
18087277
ENSG00000134001
EIF2S1
cancer
18342855
ENSG00000134001
EIF2S1
tumors
18451152
ENSG00000134001
EIF2S1
tumour
18553083
ENSG00000134001
EIF2S1
breast cancer
18559534
ENSG00000134001
EIF2S1
tumor
18694499
ENSG00000134001
EIF2S1
cancer
18728285
ENSG00000134001
EIF2S1
breast tumor
18816594
ENSG00000134001
EIF2S1
brain tumors
19188486
ENSG00000134001
EIF2S1
cancer
19190324
ENSG00000134001
EIF2S1
tumor
19455237
ENSG00000134001
EIF2S1
tumor
19671918
ENSG00000134001
EIF2S1
breast cancer
19674193
ENSG00000134001
EIF2S1
tumor
19754954
ENSG00000134001
EIF2S1
cancer
19881538
ENSG00000134001
EIF2S1
cancer
19934253
ENSG00000134001
EIF2S1
Tumor
20029030
ENSG00000134001
EIF2S1
tumor
20145727
ENSG00000134001
EIF2S1
tumor
20453876
ENSG00000134001
EIF2S1
tumours
20473272
ENSG00000134001
EIF2S1
cancer
20596679
ENSG00000134001
EIF2S1
Tumor
20660158
ENSG00000134001
EIF2S1
cancer
20709751
ENSG00000134001
EIF2S1
tumor
20924113
ENSG00000134001
EIF2S1
cancer
21076179
ENSG00000134001
EIF2S1
tumors
21085474
ENSG00000134001
EIF2S1
breast cancer
21090173
ENSG00000134001
EIF2S1
colon cancer
21268086
ENSG00000134001
EIF2S1
AML
21368877
ENSG00000134001
EIF2S1
breast cancer
21537465
ENSG00000134001
EIF2S1
breast cancer
21645946
ENSG00000134001
EIF2S1
tumors
21730287
ENSG00000134001
EIF2S1
Cancer
21765405
ENSG00000134001
EIF2S1
cancer
21775270
ENSG00000134001
EIF2S1
tumor
21795329
ENSG00000134001
EIF2S1
breast cancer
21796794
ENSG00000134001
EIF2S1
breast cancer
21887339
ENSG00000134001
EIF2S1
tumors
21954288
ENSG00000134001
EIF2S1
tumor
22009178
ENSG00000134001
EIF2S1
tumor
22018000
ENSG00000134001
EIF2S1
cancer
22056078
ENSG00000134001
EIF2S1
Non-Small Cell Lung Cancer
22102852
ENSG00000134001
EIF2S1
tumor
22105359
ENSG00000134001
EIF2S1
tumor
22106287
ENSG00000134001
EIF2S1
cancer
22231169
ENSG00000134001
EIF2S1
colorectal cancer
22268531
ENSG00000134001
EIF2S1
tumor
22429849
ENSG00000134001
EIF2S1
tumour
22519596
ENSG00000134001
EIF2S1
tumors
22719073
ENSG00000134001
EIF2S1
tumor
22733998
ENSG00000134001
EIF2S1
tumor
22768104
ENSG00000134001
EIF2S1
head and neck cancer
22920673
ENSG00000134001
EIF2S1
tumors
22934019
ENSG00000134001
EIF2S1
cancer
22935625
ENSG00000134001
EIF2S1
breast cancer
23029376
ENSG00000134001
EIF2S1
tumor
23045272
ENSG00000134001
EIF2S1
cancer
23050960
ENSG00000134001
EIF2S1
cancer
23133576
ENSG00000134001
EIF2S1
cancer
23202942
ENSG00000134001
EIF2S1
acute myeloid leukemia (AML)
23259068
ENSG00000134001
EIF2S1
tumor
23328692
ENSG00000134001
EIF2S1
colon cancer
23333652
ENSG00000134001
EIF2S1
cancer
23354132
ENSG00000134001
EIF2S1
prostate cancer
23405127
ENSG00000134001
EIF2S1
tumor
23471998
ENSG00000134001
EIF2S1
cancer
23509727
ENSG00000134001
EIF2S1
breast cancer
23706161
ENSG00000134001
EIF2S1
prostate tumors
23732991
ENSG00000134001
EIF2S1
tumor
23781265
ENSG00000134001
EIF2S1
cancer
23784735
ENSG00000134001
EIF2S1
tumor
23837763
ENSG00000134001
EIF2S1
cancers
23939221
ENSG00000134001
EIF2S1
tumor
24045183
ENSG00000134001
EIF2S1
cancer
24091475
ENSG00000134001
EIF2S1
colorectal cancer
24104354
ENSG00000134001
EIF2S1
tumor
24113185
ENSG00000134001
EIF2S1
cancer
24157877
ENSG00000134001
EIF2S1
tumor
24194639
ENSG00000134001
EIF2S1
breast cancer
24204783
ENSG00000134001
EIF2S1
cancer
24228232
ENSG00000134001
EIF2S1
tumors
24339898
ENSG00000134001
EIF2S1
tumors
24367269
ENSG00000134001
EIF2S1
colon cancer
24378333
ENSG00000134001
EIF2S1
tumor
24401334
ENSG00000134001
EIF2S1
tumor
24403234
ENSG00000134001
EIF2S1
HNSCC
24457597
ENSG00000134001
EIF2S1
tumors
24525736
ENSG00000134001
EIF2S1
colon cancer
24530917
ENSG00000134001
EIF2S1
intestinal tumors
24556688
ENSG00000134001
EIF2S1
tumor
24609900
ENSG00000134001
EIF2S1
HNSCC
24634103
ENSG00000134001
EIF2S1
breast cancer
24691491
ENSG00000134001
EIF2S1
tumor
24705811
ENSG00000134001
EIF2S1
breast cancer
24833337
ENSG00000134001
EIF2S1
gastric cancer
25003254
ENSG00000134001
EIF2S1
breast cancer
25115391
ENSG00000134001
EIF2S1
tumors
25225843
ENSG00000134001
EIF2S1
cancer
25232957
ENSG00000134001
EIF2S1
tumor
25337575
ENSG00000134001
EIF2S1
prostate cancer
25425213
ENSG00000134001
EIF2S1
tumor
25464034
ENSG00000134001
EIF2S1
cancer
25497381
ENSG00000134001
EIF2S1
tumor
25533479
ENSG00000134001
EIF2S1
prostate cancer
25576733
ENSG00000134001
EIF2S1
breast tumor
25590579
ENSG00000134001
EIF2S1
tumor
25590801
ENSG00000134001
EIF2S1
tumors
25594042
ENSG00000134001
EIF2S1
ovarian cancer
25663310
ENSG00000134001
EIF2S1
GBM
25736380
ENSG00000134001
EIF2S1
breast cancer
25762631
ENSG00000134001
EIF2S1
lung cancer
25798539
ENSG00000134001
EIF2S1
colon cancer
25901510
ENSG00000134001
EIF2S1
HNSCC
25933118
ENSG00000134001
EIF2S1
cancer
25986937
ENSG00000134001
EIF2S1
AML
26004183
ENSG00000134001
EIF2S1
tumor
26039820
ENSG00000134001
EIF2S1
prostate cancer
26075749
ENSG00000134001
EIF2S1
tumor
26123823
ENSG00000134001
EIF2S1
cancer
26175659
ENSG00000134001
EIF2S1
colorectal cancer
26188905
ENSG00000134001
EIF2S1
cancer
26264663
ENSG00000134001
EIF2S1
breast cancer
26268696
ENSG00000134001
EIF2S1
tumors
26283179
ENSG00000134001
EIF2S1
gastric cancer
26431378
ENSG00000134001
EIF2S1
Tumor
26462293
ENSG00000134001
EIF2S1
cancer
26472187
ENSG00000134001
EIF2S1
tumors
26517677
ENSG00000134001
EIF2S1
cancer
26556863
ENSG00000134001
EIF2S1
Cancer
26636041
ENSG00000134001
EIF2S1
tumors
26655089
ENSG00000134001
EIF2S1
tumor
26709701
ENSG00000134001
EIF2S1
breast cancer
26743901
ENSG00000134001
EIF2S1
tumor
26842877
ENSG00000134001
EIF2S1
breast cancer
26851676
ENSG00000134001
EIF2S1
tumor
26884600
ENSG00000134001
EIF2S1
tumors
26893923
ENSG00000134001
EIF2S1
cancer
26898246
ENSG00000134001
EIF2S1
ovarian cancer
26902409
ENSG00000134001
EIF2S1
tumor
26934000
ENSG00000134001
EIF2S1
tumor
27015562
ENSG00000134001
EIF2S1
cancer
27059255
ENSG00000134001
EIF2S1
cancer
27083003
ENSG00000134001
EIF2S1
breast cancer
27109102
ENSG00000134001
EIF2S1
GBM
27186404
ENSG00000134001
EIF2S1
cancer
27196668
ENSG00000134001
EIF2S1
Tumor
27211800
ENSG00000134001
EIF2S1
tumor
27259258
ENSG00000134001
EIF2S1
Breast Cancer
27272779
ENSG00000134001
EIF2S1
tumor
27308392
ENSG00000134001
EIF2S1
tumor
27379204
ENSG00000134001
EIF2S1
prostate cancer
27587023
ENSG00000134001
EIF2S1
tumors
27618366
ENSG00000134001
EIF2S1
tumors
27705910
ENSG00000134001
EIF2S1
gastric cancer
27708226
ENSG00000134001
EIF2S1
ovarian cancer
27729194
ENSG00000134001
EIF2S1
cancer
27802179
ENSG00000134001
EIF2S1
prostate cancer
27896021
ENSG00000134001
EIF2S1
tumor
27899592
ENSG00000134001
EIF2S1
cancer
27958308
ENSG00000134001
EIF2S1
colorectal cancer
27965097
ENSG00000134001
EIF2S1
tumor
28083147
ENSG00000134001
EIF2S1
cancer
28105371
ENSG00000134001
EIF2S1
lung cancer
28112178
ENSG00000134001
EIF2S1
colon tumor
28119311
ENSG00000134001
EIF2S1
Cancer
28185329
ENSG00000134001
EIF2S1
cancer
28197379
ENSG00000134001
EIF2S1
tumor
28293639
ENSG00000134001
EIF2S1
breast cancer
28294178
ENSG00000134001
EIF2S1
colon cancer
28300830
ENSG00000134001
EIF2S1
lung cancer
28332554
ENSG00000134001
EIF2S1
breast cancer
28374823
ENSG00000134001
EIF2S1
Cancer
28461326
ENSG00000134001
EIF2S1
prostatic cancer
28731173
ENSG00000134001
EIF2S1
tumor
28749466
ENSG00000134001
EIF2S1
cancer
28798901
ENSG00000134001
EIF2S1
tumors
28846078
ENSG00000134001
EIF2S1
GBM
29033794
ENSG00000134001
EIF2S1
Tumor
29053414
ENSG00000134001
EIF2S1
cancer
29118075
ENSG00000134001
EIF2S1
cancer
29152224
ENSG00000134001
EIF2S1
tumor
29245915
ENSG00000134001
EIF2S1
lung cancer
29245990
ENSG00000134001
EIF2S1
tumor
29254159
ENSG00000134001
EIF2S1
cancers
29358668
ENSG00000134001
EIF2S1
triple negative breast cancer
29383104
ENSG00000134001
EIF2S1
colon tumor
29393371
ENSG00000134001
EIF2S1
cancer
29486283
ENSG00000134001
EIF2S1
tumor
29507695
ENSG00000134001
EIF2S1
tumor
29531800
ENSG00000134001
EIF2S1
cancer
29559670
ENSG00000134001
EIF2S1
Cancer
29592897
ENSG00000134001
EIF2S1
lung cancers
29624814
ENSG00000134001
EIF2S1
lung cancer
29719463
ENSG00000134001
EIF2S1
tumor
29720449
ENSG00000134001
EIF2S1
pancreatic cancer
29720726
ENSG00000134001
EIF2S1
tumors
29772680
ENSG00000134001
EIF2S1
cancer
29786657
ENSG00000134001
EIF2S1
breast cancer
29802332
ENSG00000134001
EIF2S1
bladder cancer
29805643
ENSG00000134001
EIF2S1
endometrial cancer
29844817
ENSG00000134001
EIF2S1
prostate cancer
29845238
ENSG00000134001
EIF2S1
tumor
29872560
ENSG00000134001
EIF2S1
cancer
29879413
ENSG00000134001
EIF2S1
tumor
29923797
ENSG00000134001
EIF2S1
cancer
29957018
ENSG00000134001
EIF2S1
cancer
29973939
ENSG00000134001
EIF2S1
GBM
29991528
ENSG00000134001
EIF2S1
tumor
30015873
ENSG00000134001
EIF2S1
prostate cancer
30024379
ENSG00000134001
EIF2S1
GBM
30037656
ENSG00000134001
EIF2S1
tumor
30062064
ENSG00000134001
EIF2S1
Cancer
30081573
ENSG00000134001
EIF2S1
tumors
30140005
ENSG00000134001
EIF2S1
prostate cancer
30196486
ENSG00000134001
EIF2S1
tumor
30246439
ENSG00000134001
EIF2S1
thyroid cancers
30305285
ENSG00000134001
EIF2S1
Lung Cancer
30305853
ENSG00000134001
EIF2S1
gallbladder cancer
30344724
ENSG00000134001
EIF2S1
gastric cancer
30380689
ENSG00000134001
EIF2S1
cancer
30416377
ENSG00000134001
EIF2S1
cancer
30424508
ENSG00000134001
EIF2S1
breast cancer
30458886
ENSG00000134001
EIF2S1
cancer
30466445
ENSG00000134001
EIF2S1
prostate cancer
30541589
ENSG00000134001
EIF2S1
tumours
30634982
ENSG00000134001
EIF2S1
breast cancer
30652414
ENSG00000134001
EIF2S1
Breast Cancers
30655322
ENSG00000134001
EIF2S1
breast cancer
30699057
ENSG00000134001
EIF2S1
tumor
30713500
ENSG00000134001
EIF2S1
lung cancer
30717537
ENSG00000134001
EIF2S1
tumor
30719230
ENSG00000134001
EIF2S1
tumor
30754624
ENSG00000134001
EIF2S1
tumour
30800296
ENSG00000134001
EIF2S1
cancer
30813301
ENSG00000134001
EIF2S1
colon cancer
30824833
ENSG00000134001
EIF2S1
cancer
30833545
ENSG00000134001
EIF2S1
tumor
30863482
ENSG00000134001
EIF2S1
colon cancer
30942231
ENSG00000134001
EIF2S1
lung cancer
31020572
ENSG00000134001
EIF2S1
breast cancer
31022492
ENSG00000134001
EIF2S1
ovarian cancer
31046771
ENSG00000134001
EIF2S1
tumor
31064137
ENSG00000134001
EIF2S1
tumours
31071975
ENSG00000134001
EIF2S1
tumor
31086176
ENSG00000134001
EIF2S1
testicular cancer
31145545
ENSG00000134001
EIF2S1
breast cancer
31211507
ENSG00000134001
EIF2S1
colorectal cancer
31243264
ENSG00000134001
EIF2S1
liver cancer
31261976
ENSG00000134001
EIF2S1
breast cancer
31312024
ENSG00000134001
EIF2S1
Non-small-cell Lung Cancer
31360107
ENSG00000134001
EIF2S1
tumors
31380285
ENSG00000134001
EIF2S1
cancer
31410019
ENSG00000134001
EIF2S1
cancer
31491919
ENSG00000134001
EIF2S1
breast cancer
31497357
ENSG00000134001
EIF2S1
tumor
31546103
ENSG00000134001
EIF2S1
tumor
31582720
ENSG00000134001
EIF2S1
Tumour
31615341
ENSG00000134001
EIF2S1
cancer
31627132
ENSG00000134001
EIF2S1
tumor
31641103
ENSG00000134001
EIF2S1
colorectal cancer
31685988
ENSG00000134001
EIF2S1
cancer
31699971
ENSG00000134001
EIF2S1
pancreatic cancer
31719837
ENSG00000134001
EIF2S1
cancer
31767828
ENSG00000134001
EIF2S1
cancer
31848319
ENSG00000134001
EIF2S1
lung cancer
31862913
ENSG00000134001
EIF2S1
Colorectal Cancer
31930117
ENSG00000134001
EIF2S1
tumor
3402451
ENSG00000134001
EIF2S1
cancer
8545108
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000134001
EIF2S1
MESO
0.00034
high
show
ENSG00000134001
EIF2S1
UVM
0.00045
high
show
ENSG00000134001
EIF2S1
PAAD
0.00035
high
show
ENSG00000134001
EIF2S1
UCEC
0.022
high
show
ENSG00000134001
EIF2S1
THCA
0.015
high
show
ENSG00000134001
EIF2S1
LGG
0.018
low
show
ENSG00000134001
EIF2S1
LUSC
0.028
low
show
ENSG00000134001
EIF2S1
HNSC
0.0018
high
show
ENSG00000134001
EIF2S1
KIRP
0.0024
high
show
ENSG00000134001
EIF2S1
LUAD
0.00082
high
show
ENSG00000134001
EIF2S1
PCPG
0.0041
low
show
ENSG00000134001
EIF2S1
BRCA
0.021
high
show
ENSG00000134001
EIF2S1
COAD
0.025
low
show
ENSG00000134001
EIF2S1
OV
0.013
low
show
ENSG00000134001
EIF2S1
DLBC
0.0092
low
show
ENSG00000134001
EIF2S1
BLCA
0.00065
high
show
ENSG00000134001
EIF2S1
LAML
0.0044
high
show
ENSG00000134001
EIF2S1
GBM
0.013
low
show
ENSG00000134001
EIF2S1
SKCM
0.0057
low
show
ENSG00000134001
EIF2S1
CESC
0.022
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000134001
EIF2S1
CHOL
Del
2.182599
0.330810
0.606633
0.583333
ENSG00000134001
EIF2S1
LGG
Del
11.802222
0.113963
0.547689
0.235867
ENSG00000134001
EIF2S1
SARC
Del
1.000539
0.130592
0.559223
0.311284
ENSG00000134001
EIF2S1
GBM
Del
2.651524
0.073553
0.593074
0.301560
ENSG00000134001
EIF2S1
LIHC
Del
3.409991
0.103583
0.525032
0.345946
ENSG00000134001
EIF2S1
BRCA
Del
6.378517
0.099343
0.424171
0.323148
ENSG00000134001
EIF2S1
STAD
Del
1.999310
0.078560
0.337425
0.297052
ENSG00000134001
EIF2S1
KIRC
Del
0.682869
0.024196
0.427367
0.429924
ENSG00000134001
EIF2S1
OV
Del
5.497353
0.252618
0.546803
0.514680
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