Ensembl ID ENSG00000134001 Gene ID 1965 Accession 3265
Gene Symbol EIF2S1 Alias EIF2;EIF-2;EIF2A;EIF-2A;EIF-2alpha Full Name eukaryotic translation initiation factor 2 subunit alpha
Position 14 : 67360328 - 67386516 Length 26189 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

ENSG00000134001 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000134001 EIF2S1 0.56 7.33e-15 KICH
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000134001 EIF2S1 tumour 10432301
ENSG00000134001 EIF2S1 tumor 10497873
ENSG00000134001 EIF2S1 tumor 10558914
ENSG00000134001 EIF2S1 tumours 10841309
ENSG00000134001 EIF2S1 cancer 11101152
ENSG00000134001 EIF2S1 tumor 11333223
ENSG00000134001 EIF2S1 tumor 11447118
ENSG00000134001 EIF2S1 lung cancer 11956076
ENSG00000134001 EIF2S1 thyroid cancer 12186496
ENSG00000134001 EIF2S1 cancer 12214268
ENSG00000134001 EIF2S1 tumor 12706348
ENSG00000134001 EIF2S1 tumour 15094767
ENSG00000134001 EIF2S1 tumor 15178489
ENSG00000134001 EIF2S1 cancer 15456240
ENSG00000134001 EIF2S1 Tumor 16124003
ENSG00000134001 EIF2S1 prostate cancer 16204082
ENSG00000134001 EIF2S1 tumors 16472113
ENSG00000134001 EIF2S1 tumor 16861899
ENSG00000134001 EIF2S1 tumor 17113348
ENSG00000134001 EIF2S1 cancer 17213191
ENSG00000134001 EIF2S1 tumor 17215292
ENSG00000134001 EIF2S1 tumor 17283163
ENSG00000134001 EIF2S1 tumour 17341295
ENSG00000134001 EIF2S1 tumour 17387345
ENSG00000134001 EIF2S1 cancer 17531337
ENSG00000134001 EIF2S1 tumour 17623010
ENSG00000134001 EIF2S1 tumor 17637831
ENSG00000134001 EIF2S1 cancer 18087277
ENSG00000134001 EIF2S1 cancer 18342855
ENSG00000134001 EIF2S1 tumors 18451152
ENSG00000134001 EIF2S1 tumour 18553083
ENSG00000134001 EIF2S1 breast cancer 18559534
ENSG00000134001 EIF2S1 tumor 18694499
ENSG00000134001 EIF2S1 cancer 18728285
ENSG00000134001 EIF2S1 breast tumor 18816594
ENSG00000134001 EIF2S1 brain tumors 19188486
ENSG00000134001 EIF2S1 cancer 19190324
ENSG00000134001 EIF2S1 tumor 19455237
ENSG00000134001 EIF2S1 tumor 19671918
ENSG00000134001 EIF2S1 breast cancer 19674193
ENSG00000134001 EIF2S1 tumor 19754954
ENSG00000134001 EIF2S1 cancer 19881538
ENSG00000134001 EIF2S1 cancer 19934253
ENSG00000134001 EIF2S1 Tumor 20029030
ENSG00000134001 EIF2S1 tumor 20145727
ENSG00000134001 EIF2S1 tumor 20453876
ENSG00000134001 EIF2S1 tumours 20473272
ENSG00000134001 EIF2S1 cancer 20596679
ENSG00000134001 EIF2S1 Tumor 20660158
ENSG00000134001 EIF2S1 cancer 20709751
ENSG00000134001 EIF2S1 tumor 20924113
ENSG00000134001 EIF2S1 cancer 21076179
ENSG00000134001 EIF2S1 tumors 21085474
ENSG00000134001 EIF2S1 breast cancer 21090173
ENSG00000134001 EIF2S1 colon cancer 21268086
ENSG00000134001 EIF2S1 AML 21368877
ENSG00000134001 EIF2S1 breast cancer 21537465
ENSG00000134001 EIF2S1 breast cancer 21645946
ENSG00000134001 EIF2S1 tumors 21730287
ENSG00000134001 EIF2S1 Cancer 21765405
ENSG00000134001 EIF2S1 cancer 21775270
ENSG00000134001 EIF2S1 tumor 21795329
ENSG00000134001 EIF2S1 breast cancer 21796794
ENSG00000134001 EIF2S1 breast cancer 21887339
ENSG00000134001 EIF2S1 tumors 21954288
ENSG00000134001 EIF2S1 tumor 22009178
ENSG00000134001 EIF2S1 tumor 22018000
ENSG00000134001 EIF2S1 cancer 22056078
ENSG00000134001 EIF2S1 Non-Small Cell Lung Cancer 22102852
ENSG00000134001 EIF2S1 tumor 22105359
ENSG00000134001 EIF2S1 tumor 22106287
ENSG00000134001 EIF2S1 cancer 22231169
ENSG00000134001 EIF2S1 colorectal cancer 22268531
ENSG00000134001 EIF2S1 tumor 22429849
ENSG00000134001 EIF2S1 tumour 22519596
ENSG00000134001 EIF2S1 tumors 22719073
ENSG00000134001 EIF2S1 tumor 22733998
ENSG00000134001 EIF2S1 tumor 22768104
ENSG00000134001 EIF2S1 head and neck cancer 22920673
ENSG00000134001 EIF2S1 tumors 22934019
ENSG00000134001 EIF2S1 cancer 22935625
ENSG00000134001 EIF2S1 breast cancer 23029376
ENSG00000134001 EIF2S1 tumor 23045272
ENSG00000134001 EIF2S1 cancer 23050960
ENSG00000134001 EIF2S1 cancer 23133576
ENSG00000134001 EIF2S1 cancer 23202942
ENSG00000134001 EIF2S1 acute myeloid leukemia (AML) 23259068
ENSG00000134001 EIF2S1 tumor 23328692
ENSG00000134001 EIF2S1 colon cancer 23333652
ENSG00000134001 EIF2S1 cancer 23354132
ENSG00000134001 EIF2S1 prostate cancer 23405127
ENSG00000134001 EIF2S1 tumor 23471998
ENSG00000134001 EIF2S1 cancer 23509727
ENSG00000134001 EIF2S1 breast cancer 23706161
ENSG00000134001 EIF2S1 prostate tumors 23732991
ENSG00000134001 EIF2S1 tumor 23781265
ENSG00000134001 EIF2S1 cancer 23784735
ENSG00000134001 EIF2S1 tumor 23837763
ENSG00000134001 EIF2S1 cancers 23939221
ENSG00000134001 EIF2S1 tumor 24045183
ENSG00000134001 EIF2S1 cancer 24091475
ENSG00000134001 EIF2S1 colorectal cancer 24104354
ENSG00000134001 EIF2S1 tumor 24113185
ENSG00000134001 EIF2S1 cancer 24157877
ENSG00000134001 EIF2S1 tumor 24194639
ENSG00000134001 EIF2S1 breast cancer 24204783
ENSG00000134001 EIF2S1 cancer 24228232
ENSG00000134001 EIF2S1 tumors 24339898
ENSG00000134001 EIF2S1 tumors 24367269
ENSG00000134001 EIF2S1 colon cancer 24378333
ENSG00000134001 EIF2S1 tumor 24401334
ENSG00000134001 EIF2S1 tumor 24403234
ENSG00000134001 EIF2S1 HNSCC 24457597
ENSG00000134001 EIF2S1 tumors 24525736
ENSG00000134001 EIF2S1 colon cancer 24530917
ENSG00000134001 EIF2S1 intestinal tumors 24556688
ENSG00000134001 EIF2S1 tumor 24609900
ENSG00000134001 EIF2S1 HNSCC 24634103
ENSG00000134001 EIF2S1 breast cancer 24691491
ENSG00000134001 EIF2S1 tumor 24705811
ENSG00000134001 EIF2S1 breast cancer 24833337
ENSG00000134001 EIF2S1 gastric cancer 25003254
ENSG00000134001 EIF2S1 breast cancer 25115391
ENSG00000134001 EIF2S1 tumors 25225843
ENSG00000134001 EIF2S1 cancer 25232957
ENSG00000134001 EIF2S1 tumor 25337575
ENSG00000134001 EIF2S1 prostate cancer 25425213
ENSG00000134001 EIF2S1 tumor 25464034
ENSG00000134001 EIF2S1 cancer 25497381
ENSG00000134001 EIF2S1 tumor 25533479
ENSG00000134001 EIF2S1 prostate cancer 25576733
ENSG00000134001 EIF2S1 breast tumor 25590579
ENSG00000134001 EIF2S1 tumor 25590801
ENSG00000134001 EIF2S1 tumors 25594042
ENSG00000134001 EIF2S1 ovarian cancer 25663310
ENSG00000134001 EIF2S1 GBM 25736380
ENSG00000134001 EIF2S1 breast cancer 25762631
ENSG00000134001 EIF2S1 lung cancer 25798539
ENSG00000134001 EIF2S1 colon cancer 25901510
ENSG00000134001 EIF2S1 HNSCC 25933118
ENSG00000134001 EIF2S1 cancer 25986937
ENSG00000134001 EIF2S1 AML 26004183
ENSG00000134001 EIF2S1 tumor 26039820
ENSG00000134001 EIF2S1 prostate cancer 26075749
ENSG00000134001 EIF2S1 tumor 26123823
ENSG00000134001 EIF2S1 cancer 26175659
ENSG00000134001 EIF2S1 colorectal cancer 26188905
ENSG00000134001 EIF2S1 cancer 26264663
ENSG00000134001 EIF2S1 breast cancer 26268696
ENSG00000134001 EIF2S1 tumors 26283179
ENSG00000134001 EIF2S1 gastric cancer 26431378
ENSG00000134001 EIF2S1 Tumor 26462293
ENSG00000134001 EIF2S1 cancer 26472187
ENSG00000134001 EIF2S1 tumors 26517677
ENSG00000134001 EIF2S1 cancer 26556863
ENSG00000134001 EIF2S1 Cancer 26636041
ENSG00000134001 EIF2S1 tumors 26655089
ENSG00000134001 EIF2S1 tumor 26709701
ENSG00000134001 EIF2S1 breast cancer 26743901
ENSG00000134001 EIF2S1 tumor 26842877
ENSG00000134001 EIF2S1 breast cancer 26851676
ENSG00000134001 EIF2S1 tumor 26884600
ENSG00000134001 EIF2S1 tumors 26893923
ENSG00000134001 EIF2S1 cancer 26898246
ENSG00000134001 EIF2S1 ovarian cancer 26902409
ENSG00000134001 EIF2S1 tumor 26934000
ENSG00000134001 EIF2S1 tumor 27015562
ENSG00000134001 EIF2S1 cancer 27059255
ENSG00000134001 EIF2S1 cancer 27083003
ENSG00000134001 EIF2S1 breast cancer 27109102
ENSG00000134001 EIF2S1 GBM 27186404
ENSG00000134001 EIF2S1 cancer 27196668
ENSG00000134001 EIF2S1 Tumor 27211800
ENSG00000134001 EIF2S1 tumor 27259258
ENSG00000134001 EIF2S1 Breast Cancer 27272779
ENSG00000134001 EIF2S1 tumor 27308392
ENSG00000134001 EIF2S1 tumor 27379204
ENSG00000134001 EIF2S1 prostate cancer 27587023
ENSG00000134001 EIF2S1 tumors 27618366
ENSG00000134001 EIF2S1 tumors 27705910
ENSG00000134001 EIF2S1 gastric cancer 27708226
ENSG00000134001 EIF2S1 ovarian cancer 27729194
ENSG00000134001 EIF2S1 cancer 27802179
ENSG00000134001 EIF2S1 prostate cancer 27896021
ENSG00000134001 EIF2S1 tumor 27899592
ENSG00000134001 EIF2S1 cancer 27958308
ENSG00000134001 EIF2S1 colorectal cancer 27965097
ENSG00000134001 EIF2S1 tumor 28083147
ENSG00000134001 EIF2S1 cancer 28105371
ENSG00000134001 EIF2S1 lung cancer 28112178
ENSG00000134001 EIF2S1 colon tumor 28119311
ENSG00000134001 EIF2S1 Cancer 28185329
ENSG00000134001 EIF2S1 cancer 28197379
ENSG00000134001 EIF2S1 tumor 28293639
ENSG00000134001 EIF2S1 breast cancer 28294178
ENSG00000134001 EIF2S1 colon cancer 28300830
ENSG00000134001 EIF2S1 lung cancer 28332554
ENSG00000134001 EIF2S1 breast cancer 28374823
ENSG00000134001 EIF2S1 Cancer 28461326
ENSG00000134001 EIF2S1 prostatic cancer 28731173
ENSG00000134001 EIF2S1 tumor 28749466
ENSG00000134001 EIF2S1 cancer 28798901
ENSG00000134001 EIF2S1 tumors 28846078
ENSG00000134001 EIF2S1 GBM 29033794
ENSG00000134001 EIF2S1 Tumor 29053414
ENSG00000134001 EIF2S1 cancer 29118075
ENSG00000134001 EIF2S1 cancer 29152224
ENSG00000134001 EIF2S1 tumor 29245915
ENSG00000134001 EIF2S1 lung cancer 29245990
ENSG00000134001 EIF2S1 tumor 29254159
ENSG00000134001 EIF2S1 cancers 29358668
ENSG00000134001 EIF2S1 triple negative breast cancer 29383104
ENSG00000134001 EIF2S1 colon tumor 29393371
ENSG00000134001 EIF2S1 cancer 29486283
ENSG00000134001 EIF2S1 tumor 29507695
ENSG00000134001 EIF2S1 tumor 29531800
ENSG00000134001 EIF2S1 cancer 29559670
ENSG00000134001 EIF2S1 Cancer 29592897
ENSG00000134001 EIF2S1 lung cancers 29624814
ENSG00000134001 EIF2S1 lung cancer 29719463
ENSG00000134001 EIF2S1 tumor 29720449
ENSG00000134001 EIF2S1 pancreatic cancer 29720726
ENSG00000134001 EIF2S1 tumors 29772680
ENSG00000134001 EIF2S1 cancer 29786657
ENSG00000134001 EIF2S1 breast cancer 29802332
ENSG00000134001 EIF2S1 bladder cancer 29805643
ENSG00000134001 EIF2S1 endometrial cancer 29844817
ENSG00000134001 EIF2S1 prostate cancer 29845238
ENSG00000134001 EIF2S1 tumor 29872560
ENSG00000134001 EIF2S1 cancer 29879413
ENSG00000134001 EIF2S1 tumor 29923797
ENSG00000134001 EIF2S1 cancer 29957018
ENSG00000134001 EIF2S1 cancer 29973939
ENSG00000134001 EIF2S1 GBM 29991528
ENSG00000134001 EIF2S1 tumor 30015873
ENSG00000134001 EIF2S1 prostate cancer 30024379
ENSG00000134001 EIF2S1 GBM 30037656
ENSG00000134001 EIF2S1 tumor 30062064
ENSG00000134001 EIF2S1 Cancer 30081573
ENSG00000134001 EIF2S1 tumors 30140005
ENSG00000134001 EIF2S1 prostate cancer 30196486
ENSG00000134001 EIF2S1 tumor 30246439
ENSG00000134001 EIF2S1 thyroid cancers 30305285
ENSG00000134001 EIF2S1 Lung Cancer 30305853
ENSG00000134001 EIF2S1 gallbladder cancer 30344724
ENSG00000134001 EIF2S1 gastric cancer 30380689
ENSG00000134001 EIF2S1 cancer 30416377
ENSG00000134001 EIF2S1 cancer 30424508
ENSG00000134001 EIF2S1 breast cancer 30458886
ENSG00000134001 EIF2S1 cancer 30466445
ENSG00000134001 EIF2S1 prostate cancer 30541589
ENSG00000134001 EIF2S1 tumours 30634982
ENSG00000134001 EIF2S1 breast cancer 30652414
ENSG00000134001 EIF2S1 Breast Cancers 30655322
ENSG00000134001 EIF2S1 breast cancer 30699057
ENSG00000134001 EIF2S1 tumor 30713500
ENSG00000134001 EIF2S1 lung cancer 30717537
ENSG00000134001 EIF2S1 tumor 30719230
ENSG00000134001 EIF2S1 tumor 30754624
ENSG00000134001 EIF2S1 tumour 30800296
ENSG00000134001 EIF2S1 cancer 30813301
ENSG00000134001 EIF2S1 colon cancer 30824833
ENSG00000134001 EIF2S1 cancer 30833545
ENSG00000134001 EIF2S1 tumor 30863482
ENSG00000134001 EIF2S1 colon cancer 30942231
ENSG00000134001 EIF2S1 lung cancer 31020572
ENSG00000134001 EIF2S1 breast cancer 31022492
ENSG00000134001 EIF2S1 ovarian cancer 31046771
ENSG00000134001 EIF2S1 tumor 31064137
ENSG00000134001 EIF2S1 tumours 31071975
ENSG00000134001 EIF2S1 tumor 31086176
ENSG00000134001 EIF2S1 testicular cancer 31145545
ENSG00000134001 EIF2S1 breast cancer 31211507
ENSG00000134001 EIF2S1 colorectal cancer 31243264
ENSG00000134001 EIF2S1 liver cancer 31261976
ENSG00000134001 EIF2S1 breast cancer 31312024
ENSG00000134001 EIF2S1 Non-small-cell Lung Cancer 31360107
ENSG00000134001 EIF2S1 tumors 31380285
ENSG00000134001 EIF2S1 cancer 31410019
ENSG00000134001 EIF2S1 cancer 31491919
ENSG00000134001 EIF2S1 breast cancer 31497357
ENSG00000134001 EIF2S1 tumor 31546103
ENSG00000134001 EIF2S1 tumor 31582720
ENSG00000134001 EIF2S1 Tumour 31615341
ENSG00000134001 EIF2S1 cancer 31627132
ENSG00000134001 EIF2S1 tumor 31641103
ENSG00000134001 EIF2S1 colorectal cancer 31685988
ENSG00000134001 EIF2S1 cancer 31699971
ENSG00000134001 EIF2S1 pancreatic cancer 31719837
ENSG00000134001 EIF2S1 cancer 31767828
ENSG00000134001 EIF2S1 cancer 31848319
ENSG00000134001 EIF2S1 lung cancer 31862913
ENSG00000134001 EIF2S1 Colorectal Cancer 31930117
ENSG00000134001 EIF2S1 tumor 3402451
ENSG00000134001 EIF2S1 cancer 8545108
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000134001 EIF2S1 MESO 0.00034 high
ENSG00000134001 EIF2S1 UVM 0.00045 high
ENSG00000134001 EIF2S1 PAAD 0.00035 high
ENSG00000134001 EIF2S1 UCEC 0.022 high
ENSG00000134001 EIF2S1 THCA 0.015 high
ENSG00000134001 EIF2S1 LGG 0.018 low
ENSG00000134001 EIF2S1 LUSC 0.028 low
ENSG00000134001 EIF2S1 HNSC 0.0018 high
ENSG00000134001 EIF2S1 KIRP 0.0024 high
ENSG00000134001 EIF2S1 LUAD 0.00082 high
ENSG00000134001 EIF2S1 PCPG 0.0041 low
ENSG00000134001 EIF2S1 BRCA 0.021 high
ENSG00000134001 EIF2S1 COAD 0.025 low
ENSG00000134001 EIF2S1 OV 0.013 low
ENSG00000134001 EIF2S1 DLBC 0.0092 low
ENSG00000134001 EIF2S1 BLCA 0.00065 high
ENSG00000134001 EIF2S1 LAML 0.0044 high
ENSG00000134001 EIF2S1 GBM 0.013 low
ENSG00000134001 EIF2S1 SKCM 0.0057 low
ENSG00000134001 EIF2S1 CESC 0.022 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000134001 EIF2S1 CHOL Del 2.182599 0.330810 0.606633 0.583333
ENSG00000134001 EIF2S1 LGG Del 11.802222 0.113963 0.547689 0.235867
ENSG00000134001 EIF2S1 SARC Del 1.000539 0.130592 0.559223 0.311284
ENSG00000134001 EIF2S1 GBM Del 2.651524 0.073553 0.593074 0.301560
ENSG00000134001 EIF2S1 LIHC Del 3.409991 0.103583 0.525032 0.345946
ENSG00000134001 EIF2S1 BRCA Del 6.378517 0.099343 0.424171 0.323148
ENSG00000134001 EIF2S1 STAD Del 1.999310 0.078560 0.337425 0.297052
ENSG00000134001 EIF2S1 KIRC Del 0.682869 0.024196 0.427367 0.429924
ENSG00000134001 EIF2S1 OV Del 5.497353 0.252618 0.546803 0.514680