Ensembl ID ENSG00000133704 Gene ID 10526 Accession 9853
Gene Symbol IPO8 Alias VISS;RANBP8 Full Name importin 8
Position 12 : 30628988 - 30695869 Length 66882 bases Strand Minus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

ENSG00000133704 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000133704 IPO8 -0.4 5.32e-20 KIRC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000133704 IPO8 tumors 19014639
ENSG00000133704 IPO8 tumor 20511187
ENSG00000133704 IPO8 colon cancer 21059236
ENSG00000133704 IPO8 tumours 24001041
ENSG00000133704 IPO8 cancer 24080205
ENSG00000133704 IPO8 head and neck cancer 28262749
ENSG00000133704 IPO8 cancer 30881377
ENSG00000133704 IPO8 GBM 30894197
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000133704 IPO8 UVM 0.00075 high
ENSG00000133704 IPO8 UCEC 0.042 high
ENSG00000133704 IPO8 THCA 0.0029 high
ENSG00000133704 IPO8 ACC 0.05 high
ENSG00000133704 IPO8 LGG 0.0089 high
ENSG00000133704 IPO8 READ 0.033 low
ENSG00000133704 IPO8 KICH 0.00043 high
ENSG00000133704 IPO8 THYM 0.017 low
ENSG00000133704 IPO8 BRCA 0.019 low
ENSG00000133704 IPO8 UCS 0.0092 high
ENSG00000133704 IPO8 DLBC 0.049 low
ENSG00000133704 IPO8 PRAD 0.042 high
ENSG00000133704 IPO8 BLCA 0.03 high
ENSG00000133704 IPO8 GBM 0.031 low
ENSG00000133704 IPO8 LIHC 0.00013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000133704 IPO8 LUAD Amp 2.296863 0.155460 0.511426 0.319767
ENSG00000133704 IPO8 PAAD Amp 0.707065 0.081665 0.558012 0.217391
ENSG00000133704 IPO8 TGCT Amp 15.469363 0.545352 1.711290 0.973333