Ensembl ID ENSG00000133112 Gene ID 7178 Accession 12022
Gene Symbol TPT1 Alias HRF;p02;p23;TCTP Full Name tumor protein, translationally-controlled 1
Position 13 : 45333471 - 45341284 Length 7814 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

ENSG00000133112 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000133112 0.64 2.27e-17 KIRC
ENSG00000133112 -1.0 2.74e-27 HNSC
ENSG00000133112 -0.5 2.25e-18 BRCA
ENSG00000133112 -0.7 6.66e-14 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000133112 tumor 10343127
ENSG00000133112 tumour 10477280
ENSG00000133112 colon cancer 10880768
ENSG00000133112 tumour 10951206
ENSG00000133112 tumors 10953283
ENSG00000133112 tumor 11120605
ENSG00000133112 tumor 11156187
ENSG00000133112 tumor 11473261
ENSG00000133112 tumour 11578093
ENSG00000133112 breast cancer 11598139
ENSG00000133112 tumor 12399545
ENSG00000133112 tumor 12882707
ENSG00000133112 tumour 12922171
ENSG00000133112 tumour 12931192
ENSG00000133112 tumour 14623943
ENSG00000133112 tumor 14623968
ENSG00000133112 tumour 14687915
ENSG00000133112 prostate cancer 15162379
ENSG00000133112 tumors 15364286
ENSG00000133112 tumor 15489264
ENSG00000133112 tumor 15598614
ENSG00000133112 tumor 15878303
ENSG00000133112 tumour 16006164
ENSG00000133112 tumors 16193335
ENSG00000133112 tumour 16236172
ENSG00000133112 tumor 16638191
ENSG00000133112 breast cancer 17127214
ENSG00000133112 cancer 17201911
ENSG00000133112 tumour 17301792
ENSG00000133112 prostate cancer 17549383
ENSG00000133112 tumor 17579559
ENSG00000133112 cancer 18274553
ENSG00000133112 tumour 18298087
ENSG00000133112 cancers 18325342
ENSG00000133112 tumor 18617898
ENSG00000133112 cancer 18630514
ENSG00000133112 tumour 18692051
ENSG00000133112 tumour 18938170
ENSG00000133112 tumor 19114010
ENSG00000133112 lung cancer 19116456
ENSG00000133112 cancer 19168579
ENSG00000133112 tumour 19180095
ENSG00000133112 cancer 19262129
ENSG00000133112 tumour 19285501
ENSG00000133112 tumors 19360299
ENSG00000133112 prostate cancer 19360337
ENSG00000133112 cancer 19364479
ENSG00000133112 cancer 19397818
ENSG00000133112 tumor 19558675
ENSG00000133112 tumor 19621893
ENSG00000133112 tumour 19815065
ENSG00000133112 tumour 19901967
ENSG00000133112 tumor 20230689
ENSG00000133112 tumour 20336009
ENSG00000133112 tumors 20552026
ENSG00000133112 tumor 20795647
ENSG00000133112 tumour 20838377
ENSG00000133112 Tumor 20966960
ENSG00000133112 tumor 21036172
ENSG00000133112 tumour 21063673
ENSG00000133112 lung cancer 21081126
ENSG00000133112 cancer 21136954
ENSG00000133112 tumour 21187478
ENSG00000133112 tumor 21278788
ENSG00000133112 tumor 21304173
ENSG00000133112 colorectal cancer 21466289
ENSG00000133112 breast cancer 21478820
ENSG00000133112 tumor 21549610
ENSG00000133112 cancer 21565400
ENSG00000133112 tumor 21637603
ENSG00000133112 tumour 21728753
ENSG00000133112 breast cancer 21730980
ENSG00000133112 tumor 21795694
ENSG00000133112 cancer 21801721
ENSG00000133112 breast cancer 21945766
ENSG00000133112 tumor 21953552
ENSG00000133112 tumour 22069711
ENSG00000133112 cancer 22079950
ENSG00000133112 tumour 22125622
ENSG00000133112 tumor 22157679
ENSG00000133112 tumour 22311416
ENSG00000133112 colon cancer 22340241
ENSG00000133112 tumor 22428011
ENSG00000133112 cancer of the gastric cardia 22468085
ENSG00000133112 tumour 22503395
ENSG00000133112 cancer 22567286
ENSG00000133112 cancer 22570787
ENSG00000133112 Cancer 22649730
ENSG00000133112 Tumour 22655198
ENSG00000133112 Cancer 22666592
ENSG00000133112 cancer 22675633
ENSG00000133112 cancer 22761999
ENSG00000133112 tumour 22853445
ENSG00000133112 prostate cancer 22893039
ENSG00000133112 oral cancer 22902387
ENSG00000133112 Tumour 22912717
ENSG00000133112 tumor 22969908
ENSG00000133112 ovarian cancer 23042265
ENSG00000133112 tumors 23055753
ENSG00000133112 cancer 23122550
ENSG00000133112 breast cancer 23165143
ENSG00000133112 colorectal cancer 23203071
ENSG00000133112 ovarian cancer 23323103
ENSG00000133112 pancreatic cancer 23358553
ENSG00000133112 tumour 23387829
ENSG00000133112 tumor 23434429
ENSG00000133112 tumour 23520509
ENSG00000133112 tumor 23749504
ENSG00000133112 Prostate Cancer 23894469
ENSG00000133112 tumor 24004562
ENSG00000133112 Tumour 24040826
ENSG00000133112 Tumor 24122620
ENSG00000133112 tumour 24124757
ENSG00000133112 pancreatic cancer 24165482
ENSG00000133112 tumor 24248465
ENSG00000133112 tumour 24280521
ENSG00000133112 tumor 24311645
ENSG00000133112 tumour 24329985
ENSG00000133112 cancer 24352200
ENSG00000133112 tumor 24359616
ENSG00000133112 tumor 24402820
ENSG00000133112 cancer 24606760
ENSG00000133112 cancers 24650927
ENSG00000133112 tumor 24657995
ENSG00000133112 lung cancer 24761856
ENSG00000133112 tumors 25092287
ENSG00000133112 cancers 25211298
ENSG00000133112 cancer 25245035
ENSG00000133112 DLBCL 25363345
ENSG00000133112 tumour 25376500
ENSG00000133112 tumor 25396429
ENSG00000133112 lung cancer 25423047
ENSG00000133112 tumor 25487856
ENSG00000133112 tumor 25494248
ENSG00000133112 cancer 25558447
ENSG00000133112 epithelial ovarian cancer 25564355
ENSG00000133112 colon cancer 25622969
ENSG00000133112 tumor 25667934
ENSG00000133112 breast cancer 25779659
ENSG00000133112 tumour 25936523
ENSG00000133112 tumour 26011413
ENSG00000133112 tumour 26290464
ENSG00000133112 tumor 26328748
ENSG00000133112 tumor 26425551
ENSG00000133112 gastric cancer 26499154
ENSG00000133112 tumour 26808010
ENSG00000133112 cancer 26813996
ENSG00000133112 cervical cancer 26854447
ENSG00000133112 breast cancers 26903505
ENSG00000133112 cancer 26921194
ENSG00000133112 tumor 26972431
ENSG00000133112 tumour 27159273
ENSG00000133112 colorectal cancer 27367023
ENSG00000133112 tumor 27382303
ENSG00000133112 breast cancer 27416835
ENSG00000133112 Cancer 27607350
ENSG00000133112 cancers 27687497
ENSG00000133112 tumor 27764782
ENSG00000133112 tumor 27783042
ENSG00000133112 cancer 27813490
ENSG00000133112 tumour 27917920
ENSG00000133112 lung cancers 28128835
ENSG00000133112 colon cancer 28143584
ENSG00000133112 tumour 28403226
ENSG00000133112 tumor 28409693
ENSG00000133112 prostate cancer 28472637
ENSG00000133112 tumor 28506239
ENSG00000133112 cancers 28536478
ENSG00000133112 tumor 28550308
ENSG00000133112 tumour 28751755
ENSG00000133112 cancer 28846114
ENSG00000133112 tumour 28855394
ENSG00000133112 tumor 28923001
ENSG00000133112 Pancreatic Cancer 28928875
ENSG00000133112 cancers 28939212
ENSG00000133112 cancer 28958626
ENSG00000133112 tumor 28969635
ENSG00000133112 lung cancer 28970113
ENSG00000133112 tumor 29113234
ENSG00000133112 cancer 29149401
ENSG00000133112 Tumour 29149404
ENSG00000133112 tumor 29149405
ENSG00000133112 cancer 29149408
ENSG00000133112 Tumor 29149411
ENSG00000133112 Prostate Cancer 29149413
ENSG00000133112 Cancer 29149414
ENSG00000133112 Cancer 29149415
ENSG00000133112 cancer 29216544
ENSG00000133112 lung cancer 29254214
ENSG00000133112 cancer 29317542
ENSG00000133112 tumour 29324689
ENSG00000133112 tumor 29385181
ENSG00000133112 cancer 29867020
ENSG00000133112 tumor 30009039
ENSG00000133112 GBM 30029885
ENSG00000133112 tumor 30045766
ENSG00000133112 tumors 30066846
ENSG00000133112 Tumor 30370446
ENSG00000133112 Tumor 30381327
ENSG00000133112 colorectal cancer 30563768
ENSG00000133112 cancer 30695029
ENSG00000133112 Tumor 30721952
ENSG00000133112 lung cancer 30763986
ENSG00000133112 cancer 30764831
ENSG00000133112 lung cancer 30805558
ENSG00000133112 breast cancer 30815593
ENSG00000133112 tumor 30881019
ENSG00000133112 tumor 30893896
ENSG00000133112 tumor 30941821
ENSG00000133112 tumor 31015543
ENSG00000133112 tumor 31015848
ENSG00000133112 tumour 31037291
ENSG00000133112 tumor 31052313
ENSG00000133112 cervical cancer 31124937
ENSG00000133112 tumor 31146137
ENSG00000133112 tumour 31249193
ENSG00000133112 prostate cancer 31295912
ENSG00000133112 cancer 31320615
ENSG00000133112 tumor 31637705
ENSG00000133112 tumor 31715683
ENSG00000133112 cancer 31749945
ENSG00000133112 cancer 31788113
ENSG00000133112 tumor 31885695
ENSG00000133112 tumor 31935927
ENSG00000133112 tumor 31938365
ENSG00000133112 cancer 31968668
ENSG00000133112 tumour 9655922
ENSG00000133112 metastatic prostate cancer 9778121
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000133112 MESO 0.0054 low
ENSG00000133112 UCEC 0.00028 high
ENSG00000133112 LGG 0.00016 low
ENSG00000133112 HNSC 0.025 high
ENSG00000133112 READ 0.02 high
ENSG00000133112 KIRP 0.014 high
ENSG00000133112 KICH 0.026 high
ENSG00000133112 ESCA 0.011 high
ENSG00000133112 OV 0.0043 high
ENSG00000133112 KIRC 0.041 high
ENSG00000133112 LAML 0.013 low
ENSG00000133112 SKCM 0.01 low
ENSG00000133112 LIHC 0.0039 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000133112 LUSC Del 4.163186 0.105456 0.383441 0.686627
ENSG00000133112 LUAD Del 1.757268 0.064623 0.327561 0.554264
ENSG00000133112 LGG Del 3.512221 0.064579 0.448168 0.272904
ENSG00000133112 CESC Del 16.693686 0.229742 0.499782 0.389831
ENSG00000133112 READ Amp 0.728557 0.124766 1.040186 0.690909
ENSG00000133112 COAD Amp 5.554578 0.149234 0.906225 0.587583
ENSG00000133112 SARC Del 14.988214 0.356811 0.624056 0.645914
ENSG00000133112 GBM Del 10.093160 0.125903 0.581849 0.396880
ENSG00000133112 THCA Del 1.458287 0.012584 0.589039 0.036072
ENSG00000133112 HNSC Del 12.585642 0.135228 0.409596 0.419540
ENSG00000133112 LIHC Del 23.831295 0.260714 0.609658 0.472973
ENSG00000133112 BLCA Del 17.971474 0.236166 0.461476 0.338235
ENSG00000133112 BRCA Del 15.216583 0.133427 0.492656 0.458333
ENSG00000133112 PRAD Del 71.024463 0.405554 0.550752 0.457317
ENSG00000133112 UCEC Del 1.246450 0.055036 0.536740 0.194805
ENSG00000133112 MESO Del 1.544449 0.158042 0.474374 0.482759
ENSG00000133112 KIRC Del 0.746692 0.024811 0.355168 0.153409
ENSG00000133112 OV Del 4.014510 0.233920 0.623868 0.626943