Ensembl ID ENSG00000133104 Gene ID 23111 Accession 18514
Gene Symbol SPART Alias SPG20;TAHCCP1 Full Name spartin
Position 13 : 36301638 - 36370180 Length 68543 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]

ENSG00000133104 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000133104 -1.2 1.78e-12 BLCA
ENSG00000133104 -0.9 9.61e-42 BRCA
ENSG00000133104 -1.4 1.16e-15 COAD
ENSG00000133104 -2.2 8.08e-11 READ
ENSG00000133104 -0.8 3.15e-15 LUSC
ENSG00000133104 -1.0 6.99e-16 PRAD
ENSG00000133104 -1.3 5.25e-12 LIHC
ENSG00000133104 -1.5 7.46e-25 UCEC
ENSG00000133104 -0.8 1.21e-28 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000133104 colon cancer 21499309
ENSG00000133104 colorectal cancers 21777459
ENSG00000133104 cancer 23372428
ENSG00000133104 tumor 24362313
ENSG00000133104 gastric cancer 24381142
ENSG00000133104 colorectal cancer 26616813
ENSG00000133104 cancer 27353104
ENSG00000133104 colorectal cancer 28521434
ENSG00000133104 colorectal cancer 29341452
ENSG00000133104 tumors 29670109
ENSG00000133104 gastric cancer 29673586
ENSG00000133104 tumor 31109594
ENSG00000133104 gastric cancer 31194837
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000133104 MESO 0.002 low
ENSG00000133104 UVM 0.032 high
ENSG00000133104 THCA 0.014 high
ENSG00000133104 HNSC 0.0081 high
ENSG00000133104 READ 0.04 high
ENSG00000133104 KIRP 0.00069 high
ENSG00000133104 KICH 0.0036 high
ENSG00000133104 PRAD 0.025 low
ENSG00000133104 BLCA 0.044 high
ENSG00000133104 LAML 0.0075 low
ENSG00000133104 GBM 0.018 low
ENSG00000133104 SKCM 0.032 low
ENSG00000133104 LIHC 0.0068 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000133104 LUSC Del 4.765449 0.110858 0.380348 0.680639
ENSG00000133104 LUAD Del 3.993730 0.085185 0.335893 0.565891
ENSG00000133104 LGG Del 2.395670 0.055715 0.447170 0.263158
ENSG00000133104 CESC Del 12.283822 0.195244 0.498283 0.366102
ENSG00000133104 READ Amp 1.468889 0.165138 1.034708 0.709091
ENSG00000133104 COAD Amp 5.381522 0.146679 0.903731 0.585366
ENSG00000133104 UCS Del 1.011360 0.230063 0.487065 0.535714
ENSG00000133104 SARC Del 8.662229 0.274665 0.608076 0.556420
ENSG00000133104 GBM Del 6.604392 0.103949 0.568618 0.374350
ENSG00000133104 THCA Del 0.709824 0.008462 0.605404 0.030060
ENSG00000133104 HNSC Del 16.161364 0.153272 0.410434 0.442529
ENSG00000133104 LIHC Del 13.314877 0.190195 0.600659 0.416216
ENSG00000133104 BLCA Del 6.317257 0.146742 0.427780 0.272059
ENSG00000133104 BRCA Del 9.662398 0.113478 0.482569 0.427778
ENSG00000133104 STAD Amp 0.989484 0.140410 0.526620 0.390023
ENSG00000133104 PRAD Del 26.119428 0.232594 0.482724 0.317073
ENSG00000133104 UCEC Del 1.329066 0.056242 0.528414 0.196660
ENSG00000133104 MESO Del 1.956425 0.175464 0.483320 0.494253
ENSG00000133104 KIRC Del 0.735446 0.024811 0.359043 0.151515
ENSG00000133104 OV Del 2.634446 0.213538 0.627931 0.587219