Ensembl ID ENSG00000132423 Gene ID 51805 Accession 18175
Gene Symbol COQ3 Alias DHHBMT;bA9819.1;DHHBMTASE;UG0215E05 Full Name coenzyme Q3, methyltransferase
Position 6 : 99369401 - 99394195 Length 24795 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]

ENSG00000132423 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000132423 COQ3 -0.8 1.03e-18 KIRC
ENSG00000132423 COQ3 1.01 1.83e-19 KICH
ENSG00000132423 COQ3 1.66 8.96e-70 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000132423 COQ3 MESO 0.027 high
ENSG00000132423 COQ3 SARC 0.015 high
ENSG00000132423 COQ3 STAD 0.037 low
ENSG00000132423 COQ3 PAAD 0.04 low
ENSG00000132423 COQ3 UCEC 0.023 low
ENSG00000132423 COQ3 THCA 0.047 low
ENSG00000132423 COQ3 LGG 1e-04 low
ENSG00000132423 COQ3 LUSC 0.0019 low
ENSG00000132423 COQ3 HNSC 0.0092 high
ENSG00000132423 COQ3 READ 0.0017 low
ENSG00000132423 COQ3 KIRP 0.0094 low
ENSG00000132423 COQ3 KICH 0.002 high
ENSG00000132423 COQ3 LUAD 0.0036 high
ENSG00000132423 COQ3 PCPG 0.035 low
ENSG00000132423 COQ3 THYM 0.0021 low
ENSG00000132423 COQ3 BRCA 0.02 high
ENSG00000132423 COQ3 UCS 0.048 low
ENSG00000132423 COQ3 ESCA 0.0021 high
ENSG00000132423 COQ3 OV 0.049 low
ENSG00000132423 COQ3 DLBC 0.023 low
ENSG00000132423 COQ3 KIRC 0.00037 high
ENSG00000132423 COQ3 GBM 0.042 low
ENSG00000132423 COQ3 CESC 0.04 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000132423 COQ3 GBM Del 0.813626 0.053288 0.537757 0.239168
ENSG00000132423 COQ3 ESCA Del 0.674873 0.095909 0.365675 0.288043
ENSG00000132423 COQ3 SKCM Del 2.359379 0.091745 0.565392 0.564033
ENSG00000132423 COQ3 LIHC Del 1.031263 0.071104 0.599604 0.329730
ENSG00000132423 COQ3 DLBC Del 3.095537 0.259385 0.582278 0.375000
ENSG00000132423 COQ3 BLCA Del 1.569102 0.091813 0.373791 0.450980
ENSG00000132423 COQ3 BRCA Del 7.275920 0.103553 0.485067 0.330556
ENSG00000132423 COQ3 STAD Del 2.576434 0.085434 0.378705 0.199546
ENSG00000132423 COQ3 PRAD Del 49.847772 0.329416 0.555658 0.331301
ENSG00000132423 COQ3 KIRC Del 1.114593 0.027476 0.440851 0.265152