Ensembl ID ENSG00000132383 Gene ID 6117 Accession 10289
Gene Symbol RPA1 Alias HSSB;RF-A;RP-A;REPA1;RPA70;MST075;PFBMFT6 Full Name replication protein A1
Position 17 : 1829702 - 1900082 Length 70381 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017]

ENSG00000132383 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000132383 RPA1 0.76 1.03e-19 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000132383 RPA1 cancer 10419555
ENSG00000132383 RPA1 cancer 10607406
ENSG00000132383 RPA1 tumor 1310541
ENSG00000132383 RPA1 tumor 1480484
ENSG00000132383 RPA1 tumour 1525237
ENSG00000132383 RPA1 tumour 1592412
ENSG00000132383 RPA1 tumour 1592421
ENSG00000132383 RPA1 tumor 16234232
ENSG00000132383 RPA1 tumor 1689001
ENSG00000132383 RPA1 colon cancer 17361204
ENSG00000132383 RPA1 cancer 17494052
ENSG00000132383 RPA1 tumour 19066201
ENSG00000132383 RPA1 tumour 1912069
ENSG00000132383 RPA1 cancer 20139621
ENSG00000132383 RPA1 skin tumor 20947490
ENSG00000132383 RPA1 tumours 21062395
ENSG00000132383 RPA1 GBM 21617879
ENSG00000132383 RPA1 tumor 2175912
ENSG00000132383 RPA1 cancer 21901111
ENSG00000132383 RPA1 cancer 22288499
ENSG00000132383 RPA1 tumor 23420526
ENSG00000132383 RPA1 tumor 23589362
ENSG00000132383 RPA1 tumors 23960188
ENSG00000132383 RPA1 DLBCLs 24397937
ENSG00000132383 RPA1 esophageal cancer 24789547
ENSG00000132383 RPA1 cancer 25354783
ENSG00000132383 RPA1 bladder cancer 25535740
ENSG00000132383 RPA1 colorectal cancer 26403191
ENSG00000132383 RPA1 liver tumors 26810065
ENSG00000132383 RPA1 tumor 26824734
ENSG00000132383 RPA1 tumor 27043210
ENSG00000132383 RPA1 cancer 27208176
ENSG00000132383 RPA1 breast cancer 27921323
ENSG00000132383 RPA1 tumour 2846079
ENSG00000132383 RPA1 tumor 28473981
ENSG00000132383 RPA1 tumours 28557284
ENSG00000132383 RPA1 Non-Small Cell Lung Cancer 28638454
ENSG00000132383 RPA1 cancer 28683444
ENSG00000132383 RPA1 non-small cell lung cancer 29024939
ENSG00000132383 RPA1 Cancer 29108454
ENSG00000132383 RPA1 tumor 29477843
ENSG00000132383 RPA1 cancers 29601890
ENSG00000132383 RPA1 nasopharyngeal cancer 30144445
ENSG00000132383 RPA1 HNSCC 30225281
ENSG00000132383 RPA1 cervical cancer 30856376
ENSG00000132383 RPA1 colorectal cancer 30923916
ENSG00000132383 RPA1 tumor 31297925
ENSG00000132383 RPA1 cancer 31297992
ENSG00000132383 RPA1 tumors 31382494
ENSG00000132383 RPA1 cancer 31711497
ENSG00000132383 RPA1 breast cancer 31819039
ENSG00000132383 RPA1 tumour 3191193
ENSG00000132383 RPA1 tumors 782721
ENSG00000132383 RPA1 tumors 7859831
ENSG00000132383 RPA1 tumor 8098707
ENSG00000132383 RPA1 tumor 8390661
ENSG00000132383 RPA1 cancer 9523690
ENSG00000132383 RPA1 tumor 9618535
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000132383 RPA1 MESO 0.0029 high
ENSG00000132383 RPA1 SARC 0.002 high
ENSG00000132383 RPA1 UVM 8e-04 low
ENSG00000132383 RPA1 PAAD 0.014 low
ENSG00000132383 RPA1 ACC 0.035 high
ENSG00000132383 RPA1 LUSC 0.011 low
ENSG00000132383 RPA1 HNSC 0.0014 low
ENSG00000132383 RPA1 READ 0.0032 low
ENSG00000132383 RPA1 KICH 0.0017 high
ENSG00000132383 RPA1 LUAD 0.0027 high
ENSG00000132383 RPA1 PCPG 0.0079 high
ENSG00000132383 RPA1 THYM 0.049 low
ENSG00000132383 RPA1 ESCA 0.00037 low
ENSG00000132383 RPA1 PRAD 0.014 high
ENSG00000132383 RPA1 BLCA 0.037 high
ENSG00000132383 RPA1 LAML 0.0067 high
ENSG00000132383 RPA1 SKCM 0.00082 high
ENSG00000132383 RPA1 CESC 0.011 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000132383 RPA1 LUAD Del 3.046379 0.077212 0.367936 0.548450
ENSG00000132383 RPA1 SARC Del 5.248163 0.220743 0.543406 0.354086
ENSG00000132383 RPA1 LIHC Del 6.101221 0.132551 0.641437 0.562162
ENSG00000132383 RPA1 UCEC Del 0.770962 0.048609 0.578872 0.224490