Ensembl ID ENSG00000131914 Gene ID 79727 Accession 15986
Gene Symbol LIN28A Alias CSDD1;LIN28;LIN-28;ZCCHC1;lin-28A Full Name lin-28 homolog A
Position 1 : 26410817 - 26429728 Length 18912 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]

ENSG00000131914 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000131914 LIN28A 4.71 1.22e-32 BRCA
ENSG00000131914 LIN28A 4.34 1.64e-14 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000131914 LIN28A cancer 19094235
ENSG00000131914 LIN28A tumour 19153603
ENSG00000131914 LIN28A tumor 19221495
ENSG00000131914 LIN28A cancer 19483683
ENSG00000131914 LIN28A Cancer 19554373
ENSG00000131914 LIN28A tumours 19578360
ENSG00000131914 LIN28A cancer 20512147
ENSG00000131914 LIN28A cancer 20947512
ENSG00000131914 LIN28A cancer 21045151
ENSG00000131914 LIN28A tumors 21057460
ENSG00000131914 LIN28A tumors 21288558
ENSG00000131914 LIN28A malignant rhabdoid tumors 21417895
ENSG00000131914 LIN28A tumours 21533284
ENSG00000131914 LIN28A tumours 21631526
ENSG00000131914 LIN28A tumors 21725800
ENSG00000131914 LIN28A cancer 21808229
ENSG00000131914 LIN28A tumor 21835047
ENSG00000131914 LIN28A Breast Cancer 21912531
ENSG00000131914 LIN28A cancer 21982273
ENSG00000131914 LIN28A germ cell tumours 22034885
ENSG00000131914 LIN28A breast cancer 22081076
ENSG00000131914 LIN28A cancers 22118463
ENSG00000131914 LIN28A cancer 22162396
ENSG00000131914 LIN28A germ cell tumors 22296229
ENSG00000131914 LIN28A cancer 22308459
ENSG00000131914 LIN28A tumor 22314551
ENSG00000131914 LIN28A tumor 22429493
ENSG00000131914 LIN28A cancer 22467868
ENSG00000131914 LIN28A pancreatic cancer 22510406
ENSG00000131914 LIN28A breast tumors 22532168
ENSG00000131914 LIN28A cancers 22941191
ENSG00000131914 LIN28A cancer 22970210
ENSG00000131914 LIN28A tumors 23161096
ENSG00000131914 LIN28A germ cell tumors 23378032
ENSG00000131914 LIN28A cancer 23420006
ENSG00000131914 LIN28A esophageal cancer 23674108
ENSG00000131914 LIN28A colorectal cancer 23737330
ENSG00000131914 LIN28A cancer 23770886
ENSG00000131914 LIN28A malignant germ cell tumors 23774216
ENSG00000131914 LIN28A tumors 23846349
ENSG00000131914 LIN28A cancers 24040120
ENSG00000131914 LIN28A colon cancer 24213119
ENSG00000131914 LIN28A tumor 24294832
ENSG00000131914 LIN28A tumor 24337497
ENSG00000131914 LIN28A tumours 24386298
ENSG00000131914 LIN28A Tumors 24470553
ENSG00000131914 LIN28A tumors 24475120
ENSG00000131914 LIN28A tumor 24558755
ENSG00000131914 LIN28A germ cell tumours 24614704
ENSG00000131914 LIN28A tumour 24619130
ENSG00000131914 LIN28A Wilms tumors 24788514
ENSG00000131914 LIN28A tumors 24839957
ENSG00000131914 LIN28A tumor 24880079
ENSG00000131914 LIN28A tumor 25174400
ENSG00000131914 LIN28A tumors 25184046
ENSG00000131914 LIN28A tumour 25190313
ENSG00000131914 LIN28A adrenocortical cancer 25200669
ENSG00000131914 LIN28A breast cancer 25223935
ENSG00000131914 LIN28A cancer 25260650
ENSG00000131914 LIN28A cancer 25269615
ENSG00000131914 LIN28A cancer 25301052
ENSG00000131914 LIN28A tumour 25303610
ENSG00000131914 LIN28A ovarian cancer 25318762
ENSG00000131914 LIN28A cancers 25415050
ENSG00000131914 LIN28A cancer 25477749
ENSG00000131914 LIN28A Wilms tumor 25490692
ENSG00000131914 LIN28A atypical teratoid rhabdoid tumors 25638158
ENSG00000131914 LIN28A embryonal tumor 25652781
ENSG00000131914 LIN28A Embryonal Tumors 25748578
ENSG00000131914 LIN28A cancer 25774169
ENSG00000131914 LIN28A tumor 25807141
ENSG00000131914 LIN28A cancer 25883172
ENSG00000131914 LIN28A tumors 25916394
ENSG00000131914 LIN28A tumors 25956904
ENSG00000131914 LIN28A tumors 26023799
ENSG00000131914 LIN28A cancer 26080928
ENSG00000131914 LIN28A ovarian cancer 26082317
ENSG00000131914 LIN28A tumors 26118758
ENSG00000131914 LIN28A cancer 26123544
ENSG00000131914 LIN28A Breast Cancer 26149387
ENSG00000131914 LIN28A cancers 26244988
ENSG00000131914 LIN28A central nervous system tumors 26252622
ENSG00000131914 LIN28A tumor 26279620
ENSG00000131914 LIN28A breast cancers 26379447
ENSG00000131914 LIN28A cancer 26403261
ENSG00000131914 LIN28A cancer 26440890
ENSG00000131914 LIN28A breast cancer 26460550
ENSG00000131914 LIN28A cancer 26478718
ENSG00000131914 LIN28A Ovarian Cancer 26583126
ENSG00000131914 LIN28A cancer 26664407
ENSG00000131914 LIN28A colon cancer 26687759
ENSG00000131914 LIN28A Pediatric Tumor 26692113
ENSG00000131914 LIN28A tumor 26730174
ENSG00000131914 LIN28A Gastric Cancer 26893371
ENSG00000131914 LIN28A pancreatic cancer 26910839
ENSG00000131914 LIN28A breast cancer 26944953
ENSG00000131914 LIN28A tumors 27074032
ENSG00000131914 LIN28A cancer 27095948
ENSG00000131914 LIN28A cancer 27175225
ENSG00000131914 LIN28A cancer 27184842
ENSG00000131914 LIN28A prostate cancer 27197175
ENSG00000131914 LIN28A tumor 27258152
ENSG00000131914 LIN28A tumors 27296804
ENSG00000131914 LIN28A tumors 27357399
ENSG00000131914 LIN28A breast cancer 27494865
ENSG00000131914 LIN28A tumor 27559824
ENSG00000131914 LIN28A tumor 27589897
ENSG00000131914 LIN28A breast cancer 27611937
ENSG00000131914 LIN28A liver cancer 27721018
ENSG00000131914 LIN28A cancer 27776272
ENSG00000131914 LIN28A colon cancer 27793004
ENSG00000131914 LIN28A tumors 27835588
ENSG00000131914 LIN28A colon cancer 27859935
ENSG00000131914 LIN28A TGCT 28026145
ENSG00000131914 LIN28A cancer 28076679
ENSG00000131914 LIN28A tumor 28084458
ENSG00000131914 LIN28A breast cancer 28102845
ENSG00000131914 LIN28A Tumour 28103887
ENSG00000131914 LIN28A tumors 28179999
ENSG00000131914 LIN28A cancer 28218277
ENSG00000131914 LIN28A non-small cell lung cancer 28235063
ENSG00000131914 LIN28A tumors 28288140
ENSG00000131914 LIN28A Cancer 28400788
ENSG00000131914 LIN28A tumor 28423547
ENSG00000131914 LIN28A tumor 28500786
ENSG00000131914 LIN28A gastric cancers 28505005
ENSG00000131914 LIN28A cancers 28525643
ENSG00000131914 LIN28A AML 28569789
ENSG00000131914 LIN28A brain tumors 28582547
ENSG00000131914 LIN28A lung cancer 28587210
ENSG00000131914 LIN28A Embryonal Tumor 28744687
ENSG00000131914 LIN28A cancer 28910332
ENSG00000131914 LIN28A tumor 29064439
ENSG00000131914 LIN28A tumor 29162914
ENSG00000131914 LIN28A cancer 29302577
ENSG00000131914 LIN28A tumor 29390875
ENSG00000131914 LIN28A breast cancer 29396433
ENSG00000131914 LIN28A cancers 29724816
ENSG00000131914 LIN28A cancers 29725425
ENSG00000131914 LIN28A bladder cancer 29749495
ENSG00000131914 LIN28A gastric cancers 29802314
ENSG00000131914 LIN28A breast cancer 29848666
ENSG00000131914 LIN28A cancer 29874593
ENSG00000131914 LIN28A colorectal cancer 29944017
ENSG00000131914 LIN28A Wilms tumor 29950491
ENSG00000131914 LIN28A tumor 29963023
ENSG00000131914 LIN28A breast cancer 29995098
ENSG00000131914 LIN28A tumors 30016974
ENSG00000131914 LIN28A cancers 30029005
ENSG00000131914 LIN28A cancers 30057901
ENSG00000131914 LIN28A cancers 30174831
ENSG00000131914 LIN28A tumors 30237545
ENSG00000131914 LIN28A tumor 30266988
ENSG00000131914 LIN28A tumor 30286143
ENSG00000131914 LIN28A cancers 30340501
ENSG00000131914 LIN28A epithelial ovarian cancer 30365085
ENSG00000131914 LIN28A tumour 30394668
ENSG00000131914 LIN28A tumor 30531691
ENSG00000131914 LIN28A malignant tumors 30543854
ENSG00000131914 LIN28A tumor 30617578
ENSG00000131914 LIN28A Cancer 30651289
ENSG00000131914 LIN28A tumors 30760836
ENSG00000131914 LIN28A cancer 30825291
ENSG00000131914 LIN28A gastric cancer 30833806
ENSG00000131914 LIN28A GBM 30959276
ENSG00000131914 LIN28A tumor 30994507
ENSG00000131914 LIN28A cancer 31070303
ENSG00000131914 LIN28A non-small cell lung cancer 31096145
ENSG00000131914 LIN28A breast cancer 31140103
ENSG00000131914 LIN28A tumor 31142096
ENSG00000131914 LIN28A prostate cancer 31146720
ENSG00000131914 LIN28A cancer 31215730
ENSG00000131914 LIN28A tumours 31217897
ENSG00000131914 LIN28A Brain Tumor 31287992
ENSG00000131914 LIN28A Brain Cancer 31300489
ENSG00000131914 LIN28A tumour 31338973
ENSG00000131914 LIN28A cancer 31379107
ENSG00000131914 LIN28A tumors 31440515
ENSG00000131914 LIN28A tumor 31468250
ENSG00000131914 LIN28A tumor 31477684
ENSG00000131914 LIN28A cancer 31484926
ENSG00000131914 LIN28A tumor 31510013
ENSG00000131914 LIN28A cancer 31574415
ENSG00000131914 LIN28A breast cancer 31595560
ENSG00000131914 LIN28A cancer 31612113
ENSG00000131914 LIN28A breast cancer 31754343
ENSG00000131914 LIN28A esophageal cancer 31966697
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000131914 LIN28A UCEC 0.043 low
ENSG00000131914 LIN28A LGG 0.045 high
ENSG00000131914 LIN28A READ 0.014 low
ENSG00000131914 LIN28A KICH 0.0017 high
ENSG00000131914 LIN28A PCPG 0.035 low
ENSG00000131914 LIN28A BRCA 0.0037 high
ENSG00000131914 LIN28A COAD 0.038 low
ENSG00000131914 LIN28A UCS 0.016 high
ENSG00000131914 LIN28A PRAD 0.045 low
ENSG00000131914 LIN28A LAML 0.042 low
ENSG00000131914 LIN28A LIHC 0.0027 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000131914 LIN28A CHOL Del 20.775777 1.055584 0.679825 0.805556
ENSG00000131914 LIN28A LUSC Del 6.508994 0.125769 0.394049 0.455090
ENSG00000131914 LIN28A LUAD Del 1.863310 0.065882 0.298837 0.251938
ENSG00000131914 LIN28A CESC Del 1.104649 0.075602 0.419709 0.111864
ENSG00000131914 LIN28A KIRP Del 6.483593 0.075936 0.594665 0.177083
ENSG00000131914 LIN28A ACC Del 0.667306 0.097438 0.560033 0.388889
ENSG00000131914 LIN28A READ Del 8.712917 0.215218 0.451196 0.454545
ENSG00000131914 LIN28A COAD Del 21.781700 0.177401 0.461415 0.368071
ENSG00000131914 LIN28A GBM Del 2.536978 0.072427 0.495442 0.083189
ENSG00000131914 LIN28A PAAD Del 3.751042 0.100616 0.355841 0.358696
ENSG00000131914 LIN28A ESCA Del 2.263129 0.140038 0.365109 0.391304
ENSG00000131914 LIN28A HNSC Del 2.379029 0.071969 0.363717 0.180077
ENSG00000131914 LIN28A LIHC Del 16.397751 0.212141 0.543102 0.378378
ENSG00000131914 LIN28A PCPG Del 1.437164 0.074182 0.674963 0.623457
ENSG00000131914 LIN28A TGCT Del 0.609975 0.053411 0.350960 0.180000
ENSG00000131914 LIN28A BLCA Del 2.241575 0.101896 0.345152 0.210784
ENSG00000131914 LIN28A BRCA Del 31.979141 0.182146 0.424485 0.411111
ENSG00000131914 LIN28A STAD Del 10.210597 0.147054 0.372433 0.294785
ENSG00000131914 LIN28A UCEC Del 12.646799 0.134578 0.497340 0.155844
ENSG00000131914 LIN28A MESO Del 2.471153 0.194130 0.532818 0.275862
ENSG00000131914 LIN28A KIRC Del 8.151337 0.059874 0.420696 0.189394
ENSG00000131914 LIN28A UVM Del 1.628635 0.094732 0.783385 0.312500
ENSG00000131914 LIN28A OV Del 29.497243 0.446897 0.552195 0.445596