Ensembl ID ENSG00000131747 Gene ID 7153 Accession 11989
Gene Symbol TOP2A Alias TOP2;TP2A;TOPIIA;TOP2alpha Full Name DNA topoisomerase II alpha
Position 17 : 40388525 - 40417896 Length 29372 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

ENSG00000131747 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000131747 2.31 4.74e-58 KIRC
ENSG00000131747 1.33 1.42e-23 HNSC
ENSG00000131747 2.01 3.98e-16 BLCA
ENSG00000131747 3.50 1.57e-162 BRCA
ENSG00000131747 1.42 1.38e-34 COAD
ENSG00000131747 4.22 4.92e-223 LUSC
ENSG00000131747 1.35 1.67e-12 PRAD
ENSG00000131747 7.16 1.85e-51 GBM
ENSG00000131747 3.26 2.51e-30 KIRP
ENSG00000131747 3.90 8.32e-81 LIHC
ENSG00000131747 2.46 4.73e-30 STAD
ENSG00000131747 3.41 1.08e-80 UCEC
ENSG00000131747 2.65 1.51e-13 ESCA
ENSG00000131747 4.32 7.55e-27 CHOL
ENSG00000131747 5.75 4.71e-56 CESC
ENSG00000131747 3.85 3.50e-124 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000131747 tumors 10469452
ENSG00000131747 lung cancer 10699927
ENSG00000131747 tumor 11425459
ENSG00000131747 tumours 12165855
ENSG00000131747 tumour 12173052
ENSG00000131747 ovarian tumors 12532422
ENSG00000131747 tumor 12647367
ENSG00000131747 urinary bladder cancer 12691100
ENSG00000131747 tumors 12692309
ENSG00000131747 breast tumors 12871052
ENSG00000131747 breast cancers 12915875
ENSG00000131747 tumor 14566826
ENSG00000131747 cancer 14632727
ENSG00000131747 breast cancer 14632728
ENSG00000131747 tumors 14673046
ENSG00000131747 breast tumor 14978790
ENSG00000131747 gastric cancer 14991576
ENSG00000131747 breast cancer 15034864
ENSG00000131747 breast cancer 15068318
ENSG00000131747 tumor 15260889
ENSG00000131747 breast cancer 15628907
ENSG00000131747 tumours 15682439
ENSG00000131747 pancreatic cancer 15762277
ENSG00000131747 breast cancer 15891995
ENSG00000131747 breast cancer 16234514
ENSG00000131747 tumors 16280042
ENSG00000131747 breast tumor 16502015
ENSG00000131747 AML 16507781
ENSG00000131747 ovarian cancer 16533424
ENSG00000131747 tumour 16556665
ENSG00000131747 tumors 16682728
ENSG00000131747 tumors 16773180
ENSG00000131747 tumors 16849520
ENSG00000131747 breast cancer 16864174
ENSG00000131747 colorectal cancer 16882699
ENSG00000131747 Tumours 16935488
ENSG00000131747 breast cancer 17013533
ENSG00000131747 AML 17033956
ENSG00000131747 tumours 17088909
ENSG00000131747 breast cancer 17089011
ENSG00000131747 cancer 17100565
ENSG00000131747 tumours 17260090
ENSG00000131747 prostate cancer 17363613
ENSG00000131747 breast cancers 17453369
ENSG00000131747 cancers 17468948
ENSG00000131747 tumor 17493384
ENSG00000131747 tumors 17624412
ENSG00000131747 tumor 17638622
ENSG00000131747 breast cancer 17922046
ENSG00000131747 cancer 17922188
ENSG00000131747 cancers 17949785
ENSG00000131747 lung cancer 18078328
ENSG00000131747 breast cancers 18280644
ENSG00000131747 breast cancer 18332872
ENSG00000131747 cancers 18333132
ENSG00000131747 breast cancer 18340528
ENSG00000131747 tumor 18348204
ENSG00000131747 breast cancer 18413646
ENSG00000131747 breast cancer 18465341
ENSG00000131747 benign tumors 18522746
ENSG00000131747 tumors 18702822
ENSG00000131747 tumors 19003983
ENSG00000131747 tumor 19043454
ENSG00000131747 tumor 19061514
ENSG00000131747 tumors 19111388
ENSG00000131747 tumors 19158039
ENSG00000131747 breast-cancer 19261255
ENSG00000131747 Triple negative breast cancer 19365520
ENSG00000131747 cancer 19377506
ENSG00000131747 breast cancer 19390941
ENSG00000131747 tumors 19401546
ENSG00000131747 tumor 19417146
ENSG00000131747 tumors 19619298
ENSG00000131747 breast cancer 19620488
ENSG00000131747 tumors 19657712
ENSG00000131747 tumours 19754664
ENSG00000131747 breast cancer 19767729
ENSG00000131747 tumours 19886180
ENSG00000131747 tumors 19945923
ENSG00000131747 breast cancer 19996222
ENSG00000131747 breast cancer 20038724
ENSG00000131747 tumors 20066894
ENSG00000131747 cancer 20069504
ENSG00000131747 tumours 20079691
ENSG00000131747 breast cancer 20089371
ENSG00000131747 breast cancer 20100636
ENSG00000131747 breast cancer 20130985
ENSG00000131747 breast cancer 20371687
ENSG00000131747 breast cancer 20441774
ENSG00000131747 tumors 20459607
ENSG00000131747 tumours 20464479
ENSG00000131747 breast cancer 20525369
ENSG00000131747 tumors 20576644
ENSG00000131747 tumor 20649994
ENSG00000131747 tumor 20813715
ENSG00000131747 gastric cancer 20965966
ENSG00000131747 cancer 21060876
ENSG00000131747 cancer 21062978
ENSG00000131747 breast cancer 21082037
ENSG00000131747 cancer 21165954
ENSG00000131747 tumors 21172013
ENSG00000131747 tumor 21188112
ENSG00000131747 breast cancers 21189395
ENSG00000131747 tumor 21288332
ENSG00000131747 tumours 21338529
ENSG00000131747 tumors 21422418
ENSG00000131747 breast cancer 21435434
ENSG00000131747 tumors 21461646
ENSG00000131747 tumor 21475936
ENSG00000131747 breast cancer 21501481
ENSG00000131747 breast cancer 21614903
ENSG00000131747 prostate cancer 21629784
ENSG00000131747 tumor 21667123
ENSG00000131747 tumour 21681601
ENSG00000131747 breast cancers 21698407
ENSG00000131747 breast cancer 21705665
ENSG00000131747 tumor 21720419
ENSG00000131747 tumor 21734419
ENSG00000131747 triple-negative breast cancer 21737670
ENSG00000131747 tumours 21741827
ENSG00000131747 cancers 21768308
ENSG00000131747 cancer 21778401
ENSG00000131747 tumor 21785684
ENSG00000131747 GBM 21859839
ENSG00000131747 breast cancer 21875466
ENSG00000131747 tumor 21887332
ENSG00000131747 breast cancer 21917518
ENSG00000131747 tumor 22016618
ENSG00000131747 breast cancer 22037783
ENSG00000131747 breast cancer 22042366
ENSG00000131747 breast cancer 22083232
ENSG00000131747 GBM 22102081
ENSG00000131747 cancer 22111588
ENSG00000131747 breast cancer 22153616
ENSG00000131747 breast cancer 22160637
ENSG00000131747 tumors 22203181
ENSG00000131747 breast cancer 22204715
ENSG00000131747 breast cancer 22240029
ENSG00000131747 breast cancer 22285073
ENSG00000131747 cancer 22292074
ENSG00000131747 tumor 22300273
ENSG00000131747 cancer 22306066
ENSG00000131747 breast cancer 22318550
ENSG00000131747 breast cancers 22323914
ENSG00000131747 breast cancer 22333602
ENSG00000131747 prostate cancer 22349817
ENSG00000131747 breast cancer 22374418
ENSG00000131747 tumors 22425911
ENSG00000131747 breast cancer 22426810
ENSG00000131747 tumours 22452920
ENSG00000131747 tumors 22493625
ENSG00000131747 cervical cancer 22545419
ENSG00000131747 tumor 22554015
ENSG00000131747 breast cancer 22578285
ENSG00000131747 breast cancer 22612507
ENSG00000131747 tumour 22627319
ENSG00000131747 breast cancer 22706628
ENSG00000131747 pituitary tumor 22785131
ENSG00000131747 cancer 22829791
ENSG00000131747 ovarian cancer 22862954
ENSG00000131747 breast cancer 22864769
ENSG00000131747 breast cancer 22871798
ENSG00000131747 tumors 22900064
ENSG00000131747 cancer 22952714
ENSG00000131747 cancer 22998676
ENSG00000131747 tumours 23047592
ENSG00000131747 tumor 23071490
ENSG00000131747 tumors 23092535
ENSG00000131747 breast cancer 23135572
ENSG00000131747 prostate cancers 23145101
ENSG00000131747 cancer 23163854
ENSG00000131747 tumors 23181561
ENSG00000131747 tumor 23222298
ENSG00000131747 breast cancers 23226023
ENSG00000131747 cancer 23229142
ENSG00000131747 tumour 23239665
ENSG00000131747 tumors 23276504
ENSG00000131747 cancer 23302999
ENSG00000131747 tumor 23398928
ENSG00000131747 cervical cancer 23405241
ENSG00000131747 tumors 23470717
ENSG00000131747 cancers 23504136
ENSG00000131747 tumours 23505375
ENSG00000131747 tumors 23532817
ENSG00000131747 tumor 23537287
ENSG00000131747 tumor 23570501
ENSG00000131747 breast cancer 23628726
ENSG00000131747 tumors 23646114
ENSG00000131747 tumour 23698369
ENSG00000131747 breast cancer 23769286
ENSG00000131747 breast cancer 23778266
ENSG00000131747 tumor 23897556
ENSG00000131747 cancers 23928695
ENSG00000131747 cancer 24002654
ENSG00000131747 breast cancer 24007746
ENSG00000131747 tumors 24040940
ENSG00000131747 tumors 24072219
ENSG00000131747 tumor 24103454
ENSG00000131747 breast cancer 24106899
ENSG00000131747 cancer 24116135
ENSG00000131747 colorectal cancer 24138107
ENSG00000131747 breast cancer 24144752
ENSG00000131747 tumors 24165483
ENSG00000131747 tumor 24185117
ENSG00000131747 cancers 24216996
ENSG00000131747 breast cancer 24272208
ENSG00000131747 invasive breast cancer 24292870
ENSG00000131747 AML 24327541
ENSG00000131747 tumours 24381055
ENSG00000131747 cervical cancer 24383054
ENSG00000131747 breast cancer 24402422
ENSG00000131747 tumours 24403186
ENSG00000131747 breast cancer 24492650
ENSG00000131747 cancers 24573252
ENSG00000131747 Cancer 24637229
ENSG00000131747 lung cancer 24649266
ENSG00000131747 tumors 24665131
ENSG00000131747 breast cancer 24675496
ENSG00000131747 tumor 24682655
ENSG00000131747 cancer 24905608
ENSG00000131747 tumor 24926347
ENSG00000131747 non-small cell lung cancer 24975429
ENSG00000131747 tumor 25005255
ENSG00000131747 bladder cancer 25026175
ENSG00000131747 breast cancer 25042383
ENSG00000131747 tumor 25048628
ENSG00000131747 breast cancer 25051718
ENSG00000131747 breast cancer 25098819
ENSG00000131747 breast cancer 25202398
ENSG00000131747 prostate cancer 25237769
ENSG00000131747 cancer 25328138
ENSG00000131747 cancer 25372714
ENSG00000131747 breast cancer 25379022
ENSG00000131747 tumor 25406834
ENSG00000131747 breast tumors 25445497
ENSG00000131747 breast cancer 25481507
ENSG00000131747 tumor 25484594
ENSG00000131747 tumor 25546409
ENSG00000131747 tumour 25546926
ENSG00000131747 gastric cancer 25558650
ENSG00000131747 breast cancer 25642443
ENSG00000131747 breast cancer 25693082
ENSG00000131747 breast cancers 25695068
ENSG00000131747 tumors 25724086
ENSG00000131747 gastric cancers 25743022
ENSG00000131747 malignant peripheral nerve sheath tumours 25769404
ENSG00000131747 tumors 25777966
ENSG00000131747 tumor 25778705
ENSG00000131747 breast cancer 25846735
ENSG00000131747 tumors 25897160
ENSG00000131747 DLBCL 25931012
ENSG00000131747 cancer 25945730
ENSG00000131747 breast cancer 26008969
ENSG00000131747 breast cancer 26022247
ENSG00000131747 colorectal cancer 26040697
ENSG00000131747 gastric cancer 26050197
ENSG00000131747 cancers 26051240
ENSG00000131747 ovarian cancer 26100858
ENSG00000131747 breast cancer 26178217
ENSG00000131747 breast cancer 26252353
ENSG00000131747 tumor 26408707
ENSG00000131747 cancer 26409325
ENSG00000131747 tumors 26484051
ENSG00000131747 cancer 26527623
ENSG00000131747 tumours 26537449
ENSG00000131747 tumor 26560244
ENSG00000131747 Endometrial Cancer 26588239
ENSG00000131747 breast cancer 26608463
ENSG00000131747 non-small cell lung cancer 26617887
ENSG00000131747 cancer 26801902
ENSG00000131747 tumor 26824188
ENSG00000131747 tumor 26867764
ENSG00000131747 Breast cancer 26892392
ENSG00000131747 Gastrointestinal stromal tumors 26952515
ENSG00000131747 tumours 26994023
ENSG00000131747 breast cancer 27004791
ENSG00000131747 breast cancer 27009862
ENSG00000131747 triple negative breast cancer 27045718
ENSG00000131747 tumor 27072583
ENSG00000131747 tumour 27099339
ENSG00000131747 lung cancer 27121056
ENSG00000131747 cancer 27127018
ENSG00000131747 cervical cancer 27175798
ENSG00000131747 tumors 27184134
ENSG00000131747 tumor 27259241
ENSG00000131747 tumor 27315793
ENSG00000131747 Tumors 27329168
ENSG00000131747 cancer 27347171
ENSG00000131747 breast cancer 27441238
ENSG00000131747 tumor 27470985
ENSG00000131747 tumor 27503929
ENSG00000131747 breast cancer 27530622
ENSG00000131747 cancer 27557643
ENSG00000131747 tumour 27558965
ENSG00000131747 breast cancer 27576528
ENSG00000131747 breast cancer 27612420
ENSG00000131747 breast cancer 27695115
ENSG00000131747 breast cancer 27799773
ENSG00000131747 neuroblastic tumors 27821228
ENSG00000131747 tumor 27895586
ENSG00000131747 tumor 27924308
ENSG00000131747 tumour 27958275
ENSG00000131747 tumor 28025079
ENSG00000131747 tumor 28036271
ENSG00000131747 tumor 28052097
ENSG00000131747 gastric cancer 28056823
ENSG00000131747 cancer 28069330
ENSG00000131747 colorectal cancer 28072746
ENSG00000131747 breast cancer 28075472
ENSG00000131747 gastric cancer 28078044
ENSG00000131747 gastric cancer 28078605
ENSG00000131747 tumors 28079792
ENSG00000131747 tumor 28106765
ENSG00000131747 breast cancer 28127549
ENSG00000131747 pancreatic cancer 28223795
ENSG00000131747 tumor 28231233
ENSG00000131747 cancer 28260099
ENSG00000131747 cancers 28265354
ENSG00000131747 tumors 28355294
ENSG00000131747 triple-negative breast cancer 28409241
ENSG00000131747 cancer 28410543
ENSG00000131747 tumors 28432084
ENSG00000131747 Cancer 28454340
ENSG00000131747 tumor 28479381
ENSG00000131747 cancer 28503091
ENSG00000131747 cancer 28611105
ENSG00000131747 Breast Cancer 28661759
ENSG00000131747 breast cancer 28721363
ENSG00000131747 gallbladder cancers 28728050
ENSG00000131747 Colon Cancer 28736844
ENSG00000131747 breast cancer 28754978
ENSG00000131747 tumors 28755093
ENSG00000131747 breast cancer 28794467
ENSG00000131747 cancer 28794488
ENSG00000131747 malignant peripheral nerve sheath tumors 28813519
ENSG00000131747 breast cancer 28832682
ENSG00000131747 cancer 28839115
ENSG00000131747 Prostate Cancer 28899973
ENSG00000131747 tumor 28901457
ENSG00000131747 gastric cancer 28915696
ENSG00000131747 Cancer 28969025
ENSG00000131747 liver cancer 28977866
ENSG00000131747 pancreatic cancer 29045811
ENSG00000131747 cervical cancer 29103025
ENSG00000131747 Cancer 29108454
ENSG00000131747 tumor 29283334
ENSG00000131747 breast cancers 29323058
ENSG00000131747 breast cancer 29330624
ENSG00000131747 cancer 29335461
ENSG00000131747 tumor 29338072
ENSG00000131747 breast cancer 29417930
ENSG00000131747 laryngeal cancer 29439529
ENSG00000131747 tumors 29456350
ENSG00000131747 tumor 29487694
ENSG00000131747 cancer 29516929
ENSG00000131747 breast cancer 29530933
ENSG00000131747 pancreatic cancer 29546614
ENSG00000131747 tumor 29559845
ENSG00000131747 cancer 29574079
ENSG00000131747 luminal breast cancer 29587760
ENSG00000131747 cancer 29651323
ENSG00000131747 prostate cancer 29666839
ENSG00000131747 cancer 29670361
ENSG00000131747 tumour 29757235
ENSG00000131747 colon cancer 29761838
ENSG00000131747 tumor 29805517
ENSG00000131747 liver cancers 29843214
ENSG00000131747 tumor 29846894
ENSG00000131747 tumors 29869738
ENSG00000131747 cancers 29923182
ENSG00000131747 breast cancer 29928479
ENSG00000131747 cancer 29937926
ENSG00000131747 cancers 29966298
ENSG00000131747 GBM 29988316
ENSG00000131747 tumor 30001383
ENSG00000131747 breast cancer 30038716
ENSG00000131747 tumors 30054102
ENSG00000131747 AML 30066086
ENSG00000131747 cancer 30110445
ENSG00000131747 tumor 30132517
ENSG00000131747 cancer 30214555
ENSG00000131747 AML 30223465
ENSG00000131747 liver cancer 30296239
ENSG00000131747 gastric cancer 30336538
ENSG00000131747 cancer 30369945
ENSG00000131747 tumors 30385370
ENSG00000131747 GBM 30405856
ENSG00000131747 cancers 30410353
ENSG00000131747 tumour 30423952
ENSG00000131747 ovarian cancer 30453999
ENSG00000131747 tumor 30519354
ENSG00000131747 Breast Cancer 30520947
ENSG00000131747 cancer 30522956
ENSG00000131747 tumor 30538542
ENSG00000131747 tumor 30544723
ENSG00000131747 tumor 30583686
ENSG00000131747 bladder cancer 30588253
ENSG00000131747 cancer 30672125
ENSG00000131747 epithelial ovarian cancers 30760286
ENSG00000131747 tumors 30774662
ENSG00000131747 cancer 30886771
ENSG00000131747 tumor 30903644
ENSG00000131747 Cancer 30998359
ENSG00000131747 liver cancer 31001331
ENSG00000131747 pancreatic cancer 31061236
ENSG00000131747 tumor 31083655
ENSG00000131747 cancer 31089686
ENSG00000131747 colon cancer 31105744
ENSG00000131747 cancer 31139019
ENSG00000131747 ER+ breast cancer 31186766
ENSG00000131747 bladder cancer 31216997
ENSG00000131747 tumors 31251311
ENSG00000131747 cancer 31258761
ENSG00000131747 cancer 31271486
ENSG00000131747 cancer 31277155
ENSG00000131747 bladder cancer 31289523
ENSG00000131747 cancer 31292488
ENSG00000131747 breast cancer 31293425
ENSG00000131747 tumors 31301170
ENSG00000131747 tumour 31301217
ENSG00000131747 tumor 31318878
ENSG00000131747 tumor 31412643
ENSG00000131747 tumors 31422942
ENSG00000131747 breast cancer 31423162
ENSG00000131747 breast cancer 31428132
ENSG00000131747 tumor 31479512
ENSG00000131747 tumor 31505165
ENSG00000131747 cancer 31523390
ENSG00000131747 non-small cell lung cancer 31528121
ENSG00000131747 tumours 31537838
ENSG00000131747 prostate cancer 31545448
ENSG00000131747 cancers 31545466
ENSG00000131747 GBM 31611967
ENSG00000131747 papillary thyroid cancer 31614754
ENSG00000131747 tumor 31662984
ENSG00000131747 cancers 31675229
ENSG00000131747 esophageal cancer 31720085
ENSG00000131747 cancer 31729978
ENSG00000131747 tumor 31737106
ENSG00000131747 tumor 31771612
ENSG00000131747 breast cancer 31777591
ENSG00000131747 non-small cell lung cancer 31797573
ENSG00000131747 lung cancer 31816603
ENSG00000131747 cancers 31938217
ENSG00000131747 tumors 31949927
ENSG00000131747 prostate cancer 31967940
ENSG00000131747 tumor 31980218
ENSG00000131747 cancers 9795238
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000131747 SARC 0.00055 high
ENSG00000131747 CHOL 0.039 high
ENSG00000131747 UVM 0.00012 high
ENSG00000131747 UCEC 0.0081 high
ENSG00000131747 LUSC 0.0036 low
ENSG00000131747 HNSC 0.012 high
ENSG00000131747 READ 0.00011 low
ENSG00000131747 LUAD 3e-04 high
ENSG00000131747 PCPG 0.00062 high
ENSG00000131747 THYM 0.0018 low
ENSG00000131747 COAD 0.019 low
ENSG00000131747 OV 0.034 low
ENSG00000131747 BLCA 0.027 high
ENSG00000131747 SKCM 0.026 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000131747 ACC Del 2.749976 0.173224 0.594263 0.277778
ENSG00000131747 READ Amp 1.221755 0.151875 0.617296 0.254545
ENSG00000131747 COAD Amp 5.196879 0.144112 0.587511 0.243902
ENSG00000131747 SARC Del 0.964450 0.129749 0.446833 0.256809
ENSG00000131747 ESCA Amp 7.224665 0.565367 0.865368 0.380435
ENSG00000131747 PCPG Del 4.109698 0.118290 0.652802 0.216049
ENSG00000131747 BRCA Amp 14.084582 0.301616 0.827692 0.245370
ENSG00000131747 BRCA Del 3.671016 0.085409 0.426148 0.298148
ENSG00000131747 STAD Amp 24.009647 0.526140 0.913016 0.285714
ENSG00000131747 UCEC Amp 0.701571 0.102683 0.784791 0.079777
ENSG00000131747 UCEC Del 3.104082 0.073516 0.566221 0.194805