Ensembl ID ENSG00000130985 Gene ID 7317 Accession 12469
Gene Symbol UBA1 Alias A1S9;A1ST;GXP1;UBE1;A1S9T;AMCX1;POC20;SMAX2;UBA1A;UBE1X;VEXAS;CFAP124 Full Name ubiquitin like modifier activating enzyme 1
Position X : 47190861 - 47215128 Length 24268 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Non-canonical_RBPs
Summary The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

ENSG00000130985 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000130985 UBA1 -0.5 3.61e-21 KIRC
ENSG00000130985 UBA1 0.55 4.17e-36 BRCA
ENSG00000130985 UBA1 0.60 2.59e-11 KICH
ENSG00000130985 UBA1 0.92 1.68e-17 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000130985 UBA1 pituitary tumor 18570652
ENSG00000130985 UBA1 tumour 19014429
ENSG00000130985 UBA1 metastatic tumor 19649653
ENSG00000130985 UBA1 tumor 21621524
ENSG00000130985 UBA1 cancer 22456334
ENSG00000130985 UBA1 cancer 23151135
ENSG00000130985 UBA1 tumor 23354308
ENSG00000130985 UBA1 AML 23915341
ENSG00000130985 UBA1 cancer 26432019
ENSG00000130985 UBA1 breast cancer 26539730
ENSG00000130985 UBA1 tumor 29152096
ENSG00000130985 UBA1 tumour 29755650
ENSG00000130985 UBA1 cancer 30279270
ENSG00000130985 UBA1 prostate cancer 31404287
ENSG00000130985 UBA1 tumor 31808724
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000130985 UBA1 SARC 0.012 high
ENSG00000130985 UBA1 UVM 0.036 high
ENSG00000130985 UBA1 PAAD 0.0031 high
ENSG00000130985 UBA1 THCA 1e-04 low
ENSG00000130985 UBA1 ACC 0.021 high
ENSG00000130985 UBA1 LGG 0.004 high
ENSG00000130985 UBA1 LUSC 0.047 low
ENSG00000130985 UBA1 KIRP 0.018 high
ENSG00000130985 UBA1 LUAD 0.00076 high
ENSG00000130985 UBA1 PCPG 0.015 high
ENSG00000130985 UBA1 THYM 0.046 high
ENSG00000130985 UBA1 BRCA 0.016 high
ENSG00000130985 UBA1 PRAD 0.011 low
ENSG00000130985 UBA1 BLCA 0.012 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency