Ensembl ID ENSG00000129351 Gene ID 3609 Accession 6038
Gene Symbol ILF3 Alias CBTF;DRBF;MMP4;MPP4;NF90;NFAR;NF110;NF90a;NF90b;NF90c;NFAR2;TCP80;DRBP76;NF110b;NFAR-1;NFAR-2;NFAR90;TCP110;MPP4110;NF90ctv;NFAR110;MPHOSPH4;NF-AT-90 Full Name interleukin enhancer binding factor 3
Position 19 : 10654346 - 10692400 Length 38055 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]

ENSG00000129351 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000129351 ILF3 0.42 1.77e-14 HNSC
ENSG00000129351 ILF3 0.44 1.34e-31 BRCA
ENSG00000129351 ILF3 0.62 6.50e-25 COAD
ENSG00000129351 ILF3 0.52 1.60e-11 KICH
ENSG00000129351 ILF3 0.77 6.54e-27 LUSC
ENSG00000129351 ILF3 0.83 1.27e-37 LIHC
ENSG00000129351 ILF3 1.15 5.96e-28 CHOL
ENSG00000129351 ILF3 0.37 3.13e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000129351 ILF3 tumors 16322899
ENSG00000129351 ILF3 breast cancer 18039850
ENSG00000129351 ILF3 tumors 18476518
ENSG00000129351 ILF3 tumors 19088038
ENSG00000129351 ILF3 GBM 20668518
ENSG00000129351 ILF3 malignant peripheral nerve sheath tumor 21228063
ENSG00000129351 ILF3 epithelial ovarian cancer 21971700
ENSG00000129351 ILF3 cancer 22442257
ENSG00000129351 ILF3 tumor 22986534
ENSG00000129351 ILF3 epithelial ovarian cancer 23136613
ENSG00000129351 ILF3 Tumor 23965975
ENSG00000129351 ILF3 tumor 24120475
ENSG00000129351 ILF3 breast cancers 24160375
ENSG00000129351 ILF3 tumor 24346158
ENSG00000129351 ILF3 tumor 24965446
ENSG00000129351 ILF3 lung cancer 25075203
ENSG00000129351 ILF3 tumor 25101115
ENSG00000129351 ILF3 ovarian cancer 25285018
ENSG00000129351 ILF3 cervical cancer 25311137
ENSG00000129351 ILF3 tumor 25399696
ENSG00000129351 ILF3 breast cancer 26273641
ENSG00000129351 ILF3 cancer 26391949
ENSG00000129351 ILF3 ovarian cancer 26513889
ENSG00000129351 ILF3 tumor 26634812
ENSG00000129351 ILF3 tumor 27519414
ENSG00000129351 ILF3 tumor 27735951
ENSG00000129351 ILF3 cancer 27840950
ENSG00000129351 ILF3 breast tumors 28558830
ENSG00000129351 ILF3 cancer 28653903
ENSG00000129351 ILF3 cancer 28789687
ENSG00000129351 ILF3 Bladder Cancer 28839463
ENSG00000129351 ILF3 breast cancer 28935763
ENSG00000129351 ILF3 breast cancer 29296180
ENSG00000129351 ILF3 cancer 29413056
ENSG00000129351 ILF3 tumor 29415727
ENSG00000129351 ILF3 cervical cancer 29449553
ENSG00000129351 ILF3 cervical cancer 29525275
ENSG00000129351 ILF3 tumor 29563539
ENSG00000129351 ILF3 tumor 30060955
ENSG00000129351 ILF3 colon cancer 30195788
ENSG00000129351 ILF3 colorectal cancer 30588088
ENSG00000129351 ILF3 cancer 30796096
ENSG00000129351 ILF3 tumors 30819403
ENSG00000129351 ILF3 cancers 31022259
ENSG00000129351 ILF3 gastric cancer 31115508
ENSG00000129351 ILF3 tumors 31144362
ENSG00000129351 ILF3 cancer 31186778
ENSG00000129351 ILF3 tumor 31602267
ENSG00000129351 ILF3 cancer 31619200
ENSG00000129351 ILF3 colorectal cancer 31772275
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000129351 ILF3 MESO 0.00087 high
ENSG00000129351 ILF3 SARC 0.0046 high
ENSG00000129351 ILF3 STAD 0.00092 low
ENSG00000129351 ILF3 LGG 0.014 high
ENSG00000129351 ILF3 HNSC 0.0034 low
ENSG00000129351 ILF3 READ 0.016 low
ENSG00000129351 ILF3 KIRP 0.0039 high
ENSG00000129351 ILF3 THYM 0.00015 low
ENSG00000129351 ILF3 BRCA 0.022 low
ENSG00000129351 ILF3 COAD 0.043 high
ENSG00000129351 ILF3 KIRC 6e-04 high
ENSG00000129351 ILF3 BLCA 0.0067 low
ENSG00000129351 ILF3 GBM 0.025 low
ENSG00000129351 ILF3 SKCM 0.0029 high
ENSG00000129351 ILF3 LIHC 0.00034 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000129351 ILF3 LUAD Del 0.710833 0.051195 0.334713 0.523256
ENSG00000129351 ILF3 UCS Amp 2.244977 0.726161 1.000100 0.410714
ENSG00000129351 ILF3 SARC Amp 0.821152 0.266436 0.652812 0.420233
ENSG00000129351 ILF3 LIHC Del 4.593293 0.117043 0.465535 0.218919
ENSG00000129351 ILF3 UCEC Amp 12.631320 0.276376 0.950099 0.165121
ENSG00000129351 ILF3 UCEC Del 1.003802 0.052023 0.490680 0.103896
ENSG00000129351 ILF3 OV Amp 12.732258 0.591494 0.904795 0.409326
ENSG00000129351 ILF3 OV Del 0.815663 0.177076 0.535310 0.314335