Ensembl ID ENSG00000129084 Gene ID 5682 Accession 9530
Gene Symbol PSMA1 Alias NU;HC2;PROS30;HEL-S-275 Full Name proteasome 20S subunit alpha 1
Position 11 : 14504876 - 14643617 Length 138742 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

ENSG00000129084 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000129084 PSMA1 0.52 3.74e-24 KIRC
ENSG00000129084 PSMA1 0.32 8.41e-12 BRCA
ENSG00000129084 PSMA1 0.54 1.96e-14 COAD
ENSG00000129084 PSMA1 0.74 1.59e-11 LUSC
ENSG00000129084 PSMA1 0.52 7.61e-14 KIRP
ENSG00000129084 PSMA1 0.48 8.63e-14 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000129084 PSMA1 cervical cancer 12433717
ENSG00000129084 PSMA1 tumour 12673691
ENSG00000129084 PSMA1 cancer 12814990
ENSG00000129084 PSMA1 cancer 12958220
ENSG00000129084 PSMA1 cancer 16203281
ENSG00000129084 PSMA1 cervical cancer 16203283
ENSG00000129084 PSMA1 cervical cancer 16306782
ENSG00000129084 PSMA1 cancer 16950021
ENSG00000129084 PSMA1 breast cancer 17004105
ENSG00000129084 PSMA1 cancer 17062559
ENSG00000129084 PSMA1 breast cancer 17127214
ENSG00000129084 PSMA1 cancer 17277898
ENSG00000129084 PSMA1 tumour 17635118
ENSG00000129084 PSMA1 cancer 17854914
ENSG00000129084 PSMA1 cancer 18847555
ENSG00000129084 PSMA1 cervical cancer 19087272
ENSG00000129084 PSMA1 cervical cancer 19127262
ENSG00000129084 PSMA1 cervical tumor 19410602
ENSG00000129084 PSMA1 cervical cancer 20442585
ENSG00000129084 PSMA1 Tumour 20642475
ENSG00000129084 PSMA1 tumor 20925961
ENSG00000129084 PSMA1 cervical cancer 21051986
ENSG00000129084 PSMA1 cervical cancer 21147950
ENSG00000129084 PSMA1 cervical cancer 21334052
ENSG00000129084 PSMA1 cervical cancer 21394935
ENSG00000129084 PSMA1 cervical cancer 21415357
ENSG00000129084 PSMA1 cancer 21478701
ENSG00000129084 PSMA1 cervical cancer 22610699
ENSG00000129084 PSMA1 tumors 22685613
ENSG00000129084 PSMA1 cervical cancer 22778786
ENSG00000129084 PSMA1 cervical cancer 22877561
ENSG00000129084 PSMA1 tumor 22900617
ENSG00000129084 PSMA1 cervical cancer 23259726
ENSG00000129084 PSMA1 breast cancer 23283305
ENSG00000129084 PSMA1 cancer 23334437
ENSG00000129084 PSMA1 cancer 23342254
ENSG00000129084 PSMA1 tumor 23544127
ENSG00000129084 PSMA1 cervical cancer 23836358
ENSG00000129084 PSMA1 cancer 23959298
ENSG00000129084 PSMA1 breast cancer 23959946
ENSG00000129084 PSMA1 tumors 24040035
ENSG00000129084 PSMA1 pancreatic cancer 24060073
ENSG00000129084 PSMA1 cancer 24098429
ENSG00000129084 PSMA1 cervical cancer 24108613
ENSG00000129084 PSMA1 tumor 24156825
ENSG00000129084 PSMA1 cervical cancer 24574284
ENSG00000129084 PSMA1 cervical cancer 24642241
ENSG00000129084 PSMA1 cervical cancer 24736475
ENSG00000129084 PSMA1 cervical cancer 24814874
ENSG00000129084 PSMA1 cervical cancer 24935474
ENSG00000129084 PSMA1 tumors 25033838
ENSG00000129084 PSMA1 cervical cancer 25051098
ENSG00000129084 PSMA1 tumours 25157275
ENSG00000129084 PSMA1 colorectal cancer 25206290
ENSG00000129084 PSMA1 cancer 25339396
ENSG00000129084 PSMA1 cervical cancer 25394189
ENSG00000129084 PSMA1 cervical cancer 25449563
ENSG00000129084 PSMA1 cervical cancer 25487281
ENSG00000129084 PSMA1 cancer 25684510
ENSG00000129084 PSMA1 cervical cancer 25864682
ENSG00000129084 PSMA1 cervical cancer 25872892
ENSG00000129084 PSMA1 HNSCC 25964135
ENSG00000129084 PSMA1 cervical cancer 26081398
ENSG00000129084 PSMA1 cervical cancer 26212521
ENSG00000129084 PSMA1 cervical cancer 26276778
ENSG00000129084 PSMA1 Cancer 26486441
ENSG00000129084 PSMA1 acute myeloid leukemia (AML) 2659380
ENSG00000129084 PSMA1 cervical cancers 26693677
ENSG00000129084 PSMA1 cervical cancer 26789267
ENSG00000129084 PSMA1 cervical cancer 27307461
ENSG00000129084 PSMA1 cervical cancer 27436249
ENSG00000129084 PSMA1 Tumor 27461666
ENSG00000129084 PSMA1 cervical cancer 27821079
ENSG00000129084 PSMA1 Cervical Cancer 27851695
ENSG00000129084 PSMA1 cervical cancer 27894291
ENSG00000129084 PSMA1 tumor 27966459
ENSG00000129084 PSMA1 Cervical Cancers 28340235
ENSG00000129084 PSMA1 Cancer 28515214
ENSG00000129084 PSMA1 Cervical Cancer 28541628
ENSG00000129084 PSMA1 cervical cancer 28657227
ENSG00000129084 PSMA1 cervical cancer 28662160
ENSG00000129084 PSMA1 cervical cancer 29113275
ENSG00000129084 PSMA1 cervical cancer 29179875
ENSG00000129084 PSMA1 cervical cancer 29353972
ENSG00000129084 PSMA1 tumor 29423100
ENSG00000129084 PSMA1 breast cancer 29423411
ENSG00000129084 PSMA1 cervical cancer 29580367
ENSG00000129084 PSMA1 cervical cancer 30208597
ENSG00000129084 PSMA1 cervical cancer 30355760
ENSG00000129084 PSMA1 cervical cancer 30447695
ENSG00000129084 PSMA1 cervical cancer 30599280
ENSG00000129084 PSMA1 cancer 30854179
ENSG00000129084 PSMA1 tumor 31051683
ENSG00000129084 PSMA1 Cervical cancer 31074835
ENSG00000129084 PSMA1 cancer 31216333
ENSG00000129084 PSMA1 Cervical Cancer 31348794
ENSG00000129084 PSMA1 cervical cancer 31553700
ENSG00000129084 PSMA1 cervical cancer 31569008
ENSG00000129084 PSMA1 tumor 31576173
ENSG00000129084 PSMA1 cancer 31711435
ENSG00000129084 PSMA1 tumor 8895752
ENSG00000129084 PSMA1 tumor 9108453
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000129084 PSMA1 MESO 0.0044 high
ENSG00000129084 PSMA1 UVM 0.00047 high
ENSG00000129084 PSMA1 PAAD 0.0067 high
ENSG00000129084 PSMA1 THCA 0.037 low
ENSG00000129084 PSMA1 HNSC 0.0063 high
ENSG00000129084 PSMA1 READ 0.024 low
ENSG00000129084 PSMA1 LUAD 0.00056 high
ENSG00000129084 PSMA1 PCPG 0.0015 high
ENSG00000129084 PSMA1 BRCA 0.0056 low
ENSG00000129084 PSMA1 ESCA 0.0016 high
ENSG00000129084 PSMA1 OV 0.00052 low
ENSG00000129084 PSMA1 BLCA 0.013 low
ENSG00000129084 PSMA1 GBM 0.014 high
ENSG00000129084 PSMA1 SKCM 0.0047 low
ENSG00000129084 PSMA1 CESC 0.022 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000129084 PSMA1 LUSC Del 2.933934 0.093570 0.350387 0.403194
ENSG00000129084 PSMA1 LGG Del 1.132715 0.043897 0.555227 0.159844
ENSG00000129084 PSMA1 BLCA Del 1.736952 0.094467 0.428644 0.519608
ENSG00000129084 PSMA1 BRCA Del 1.820775 0.073279 0.408606 0.241667
ENSG00000129084 PSMA1 OV Del 7.739606 0.277487 0.572499 0.488774