Ensembl ID ENSG00000128951 Gene ID 1854 Accession 3078
Gene Symbol DUT Alias BMFDMS;dUTPase Full Name deoxyuridine triphosphatase
Position 15 : 48331011 - 48343373 Length 12363 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

ENSG00000128951 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000128951 DUT 0.79 3.86e-20 LUSC
ENSG00000128951 DUT 0.75 1.90e-13 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000128951 DUT tumours 10567908
ENSG00000128951 DUT tumor 10910061
ENSG00000128951 DUT tumour 10952785
ENSG00000128951 DUT tumour 11487279
ENSG00000128951 DUT tumor 12096336
ENSG00000128951 DUT cancer 12374095
ENSG00000128951 DUT cancers 12376965
ENSG00000128951 DUT cancers 12799180
ENSG00000128951 DUT tumor 15138564
ENSG00000128951 DUT cancer 15322254
ENSG00000128951 DUT cancer 15740738
ENSG00000128951 DUT tumors 16325515
ENSG00000128951 DUT cancer 17880943
ENSG00000128951 DUT tumor 17955371
ENSG00000128951 DUT lung cancer 18078828
ENSG00000128951 DUT breast cancer 18790783
ENSG00000128951 DUT tumor 18837522
ENSG00000128951 DUT tumor 19015155
ENSG00000128951 DUT colorectal cancer 19052026
ENSG00000128951 DUT cancer 19403629
ENSG00000128951 DUT cancer 19645683
ENSG00000128951 DUT cancer 20084279
ENSG00000128951 DUT tumor 20560137
ENSG00000128951 DUT non-small cell lung cancer 22172489
ENSG00000128951 DUT cancers 23307478
ENSG00000128951 DUT tumors 24014883
ENSG00000128951 DUT cancer 24085278
ENSG00000128951 DUT colorectal cancer 26208523
ENSG00000128951 DUT cancer 26666293
ENSG00000128951 DUT cancer 27325794
ENSG00000128951 DUT Cancer 27452458
ENSG00000128951 DUT tumor 28036046
ENSG00000128951 DUT colorectal cancer 28423595
ENSG00000128951 DUT tumor 29018771
ENSG00000128951 DUT cervical cancer 29429708
ENSG00000128951 DUT cancer 29531348
ENSG00000128951 DUT cancer 29578692
ENSG00000128951 DUT tumor 29723986
ENSG00000128951 DUT cancer 29748212
ENSG00000128951 DUT cervical cancer 30127996
ENSG00000128951 DUT tumors 30511200
ENSG00000128951 DUT cancer 30679536
ENSG00000128951 DUT tumor 31404669
ENSG00000128951 DUT colon cancer 7652165
ENSG00000128951 DUT cancer 7660876
ENSG00000128951 DUT prostate cancer 7712434
ENSG00000128951 DUT tumor 8091672
ENSG00000128951 DUT tumor 8139016
ENSG00000128951 DUT colorectal tumor 8162567
ENSG00000128951 DUT tumour 9000104
ENSG00000128951 DUT cancer 9360704
ENSG00000128951 DUT tumor 9771948
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000128951 DUT MESO 0.00072 high
ENSG00000128951 DUT SARC 0.049 low
ENSG00000128951 DUT THCA 0.021 high
ENSG00000128951 DUT LUSC 0.021 low
ENSG00000128951 DUT HNSC 0.029 high
ENSG00000128951 DUT READ 0.034 low
ENSG00000128951 DUT KIRP 0.038 low
ENSG00000128951 DUT KICH 0.004 high
ENSG00000128951 DUT LUAD 0.00017 high
ENSG00000128951 DUT THYM 0.00052 low
ENSG00000128951 DUT COAD 0.012 high
ENSG00000128951 DUT OV 0.014 low
ENSG00000128951 DUT KIRC 0.017 high
ENSG00000128951 DUT PRAD 0.012 high
ENSG00000128951 DUT BLCA 0.018 low
ENSG00000128951 DUT LAML 0.022 high
ENSG00000128951 DUT SKCM 0.00037 low
ENSG00000128951 DUT CESC 0.032 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000128951 DUT LUAD Del 1.875880 0.066092 0.313447 0.505814
ENSG00000128951 DUT CESC Del 2.341146 0.096521 0.467956 0.227119
ENSG00000128951 DUT UCS Del 3.205240 0.380861 0.539132 0.714286
ENSG00000128951 DUT GBM Del 7.197092 0.107702 0.505521 0.244367
ENSG00000128951 DUT SKCM Del 6.172040 0.134520 0.497293 0.231608
ENSG00000128951 DUT BRCA Del 3.942408 0.086913 0.391122 0.342593
ENSG00000128951 DUT STAD Del 0.806536 0.062111 0.330547 0.244898
ENSG00000128951 DUT UCEC Del 3.436793 0.076328 0.515635 0.246753
ENSG00000128951 DUT MESO Del 1.898015 0.172975 0.551791 0.172414
ENSG00000128951 DUT OV Del 4.490652 0.240277 0.572128 0.559585