Ensembl ID ENSG00000128708 Gene ID 8520 Accession 4821
Gene Symbol HAT1 Alias KAT1 Full Name histone acetyltransferase 1
Position 2 : 171922448 - 171983686 Length 61239 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

ENSG00000128708 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000128708 0.35 2.69e-15 BRCA
ENSG00000128708 -0.8 2.41e-11 KICH
ENSG00000128708 0.77 7.94e-29 LUSC
ENSG00000128708 1.25 4.27e-13 GBM
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000128708 liver tumors 17182829
ENSG00000128708 cancer 19075689
ENSG00000128708 tumors 25120766
ENSG00000128708 breast cancer 25358520
ENSG00000128708 lung cancer 29163803
ENSG00000128708 Cancer 29535128
ENSG00000128708 nasopharyngeal cancer 29621521
ENSG00000128708 pancreatic cancer 30709380
ENSG00000128708 tumor 31152456
ENSG00000128708 cancer 31278053
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000128708 MESO 0.028 high
ENSG00000128708 STAD 0.038 low
ENSG00000128708 CHOL 0.0013 high
ENSG00000128708 UVM 0.0091 high
ENSG00000128708 PAAD 0.0079 high
ENSG00000128708 UCEC 0.0076 high
ENSG00000128708 LUSC 0.017 low
ENSG00000128708 HNSC 0.0035 high
ENSG00000128708 READ 0.047 low
ENSG00000128708 KIRP 0.00034 high
ENSG00000128708 LUAD 0.011 high
ENSG00000128708 PCPG 0.032 high
ENSG00000128708 THYM 0.012 low
ENSG00000128708 COAD 0.027 low
ENSG00000128708 UCS 0.032 high
ENSG00000128708 DLBC 0.00034 low
ENSG00000128708 LAML 0.02 high
ENSG00000128708 SKCM 0.001 low
ENSG00000128708 CESC 0.0096 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000128708 KIRP Amp 0.681666 0.052092 0.615722 0.177083
ENSG00000128708 HNSC Amp 1.191100 0.128885 0.458748 0.193487
ENSG00000128708 PRAD Del 1.647782 0.084279 0.433254 0.117886
ENSG00000128708 OV Amp 1.840186 0.369327 0.601497 0.417962